Olfactory Training for Loss of Smell
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment Olfactory Training for Loss of Smell?
Research shows that olfactory training, which involves regularly smelling certain odors, can significantly improve the ability to identify, discriminate, and detect smells in people with smell disorders. This training has been effective in various conditions, including post-infectious and traumatic smell loss, and is considered a promising addition or alternative to existing treatments for olfactory dysfunction.12345
Is olfactory training safe for humans?
How does olfactory training differ from other treatments for loss of smell?
Olfactory training is unique because it involves regularly smelling specific odors to help improve the sense of smell, unlike other treatments that may not focus on sensory rehabilitation. It is the only evidence-based treatment for post-viral olfactory dysfunction and can potentially benefit psychological functioning by targeting neuroinflammation.15101112
What is the purpose of this trial?
The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.
Research Team
Nicholas Rowan, MD
Principal Investigator
Johns Hopkins School of Medicine
Eligibility Criteria
This trial is for English-speaking individuals with benign tumors at the base of their skull who haven't had previous surgeries or treatments in that area, no history of chronic sinus issues, neurocognitive disorders, or intrinsic problems with smell and taste. Those with pacemakers, gastrectomy, or malignant tumors are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Pre-operative
Baseline assessments of olfactory function and quality of life using various questionnaires
Post-operative Treatment
Participants receive either placebo or treatment olfactory training kits to assess changes in olfactory function
Follow-up
Participants are monitored for changes in quality of life and olfactory function
Treatment Details
Interventions
- Olfactory training
- Placebo training
Find a Clinic Near You
Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor
North American Skull Base Society
Collaborator