50 Participants Needed

Olfactory Training for Loss of Smell

MC
Overseen ByMichael Cheng, MD

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Olfactory Training for Loss of Smell?

Research shows that olfactory training, which involves regularly smelling certain odors, can significantly improve the ability to identify, discriminate, and detect smells in people with smell disorders. This training has been effective in various conditions, including post-infectious and traumatic smell loss, and is considered a promising addition or alternative to existing treatments for olfactory dysfunction.12345

Is olfactory training safe for humans?

The research does not report any safety concerns for olfactory training, suggesting it is generally safe for humans.56789

How does olfactory training differ from other treatments for loss of smell?

Olfactory training is unique because it involves regularly smelling specific odors to help improve the sense of smell, unlike other treatments that may not focus on sensory rehabilitation. It is the only evidence-based treatment for post-viral olfactory dysfunction and can potentially benefit psychological functioning by targeting neuroinflammation.15101112

What is the purpose of this trial?

The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.

Research Team

NR

Nicholas Rowan, MD

Principal Investigator

Johns Hopkins School of Medicine

Eligibility Criteria

This trial is for English-speaking individuals with benign tumors at the base of their skull who haven't had previous surgeries or treatments in that area, no history of chronic sinus issues, neurocognitive disorders, or intrinsic problems with smell and taste. Those with pacemakers, gastrectomy, or malignant tumors are excluded.

Inclusion Criteria

I have a non-cancerous tumor near the base of my skull.

Exclusion Criteria

I have a long-term history of sinus infections.
You have a history of brain-related memory or thinking problems.
History of cardiac pacemaker
See 6 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Pre-operative

Baseline assessments of olfactory function and quality of life using various questionnaires

1 visit
1 visit (in-person)

Post-operative Treatment

Participants receive either placebo or treatment olfactory training kits to assess changes in olfactory function

3 months
2 weeks post-operative, 1 month post-operative, 3 months post-operative

Follow-up

Participants are monitored for changes in quality of life and olfactory function

6 months
6 months post-operative

Treatment Details

Interventions

  • Olfactory training
  • Placebo training
Trial Overview The study tests if olfactory training after surgery can improve the sense of smell and quality of life faster compared to a placebo training. It's designed to understand how surgery affects smell and taste and whether specific postoperative exercises can help recovery.
Participant Groups
2Treatment groups
Experimental Treatment
Placebo Group
Group I: TreatmentExperimental Treatment1 Intervention
Participants receive treatment olfactory training kits that contain essential oils that have scents (lavender, lemon, clove, eucalyptus)
Group II: PlaceboPlacebo Group1 Intervention
Participants receive placebo olfactory training kits that only contain medium chain triglycerides that lack any discernible odor

Find a Clinic Near You

Who Is Running the Clinical Trial?

Johns Hopkins University

Lead Sponsor

Trials
2,366
Recruited
15,160,000+

North American Skull Base Society

Collaborator

Trials
2
Recruited
110+

Findings from Research

Olfactory training (OT) may not only help improve the sense of smell in individuals with olfactory disorders but could also enhance psychological functioning, potentially benefiting cognitive and emotional processes due to the direct connection between the olfactory bulb and the limbic system.
The review highlights the need for more research on OT, including its molecular and neuroanatomical effects, to better understand its role in supporting cognitive functions and overall well-being.
Olfactory training - Thirteen years of research reviewed.Pieniak, M., Oleszkiewicz, A., Avaro, V., et al.[2022]
In a study of 153 patients with post-infectious olfactory dysfunction (PIOD) receiving olfactory training, the presence of parosmia was linked to significant improvements in olfactory discrimination and identification, especially in those with lower baseline olfactory function.
Older patients showed more significant improvements in odor threshold, suggesting that age may play a role in recovery outcomes for olfactory function after training.
Parosmia is Associated with Relevant Olfactory Recovery After Olfactory Training.Liu, DT., Sabha, M., Damm, M., et al.[2021]
Olfactory training can lead to a slight improvement in odor detection thresholds in patients with traumatic anosmia, as shown by significant decreases in PEA thresholds after 6 months of training in both the 4-odorant and PEA groups.
However, while the PEA group showed a significant increase in odor identification scores, the 4-odorant group did not, indicating that the type of training may influence outcomes, and further research is needed to assess the overall clinical benefits of olfactory training.
The effect of olfactory training on odor identification in patients with traumatic anosmia.Jiang, RS., Twu, CW., Liang, KL.[2020]

References

Olfactory training - Thirteen years of research reviewed. [2022]
Parosmia is Associated with Relevant Olfactory Recovery After Olfactory Training. [2021]
The effect of olfactory training on odor identification in patients with traumatic anosmia. [2020]
Effects of olfactory training: a meta-analysis. [2022]
The effect of olfactory training on the odor threshold in patients with traumatic anosmia. [2018]
The Effect of Topical Aminophylline on Hyposmia and Anosmia. [2022]
Olfactory training in normosmic individuals: a randomised controlled trial. [2023]
The evidence for olfactory training in treating patients with olfactory loss. [2018]
[Efficacy and associated factors of olfactory training in the treatment of olfactory dysfunction]. [2019]
The effect of olfactory training on olfactory bulb volumes in patients with idiopathic olfactory loss. [2020]
11.United Arab Emiratespubmed.ncbi.nlm.nih.gov
Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo- Controlled Clinical Trial. [2023]
Position paper on olfactory dysfunction. [2022]
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