IPD Probe for Gut Permeability
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to examine the feasibility of using a trans-nasal IPD probe as a measurement tool for gut permeability
Will I have to stop taking my current medications?
The trial requires that you stop taking certain medications, such as those that delay gastric emptying, impair clotting, nasal steroids, antibiotics, H2 Histamine Antagonists, and Mast Cell stabilizers. If you are on any of these, you would need to stop them to participate.
Is the IPD Probe for Gut Permeability safe for humans?
The research does not provide specific safety data for the IPD Probe in humans, but it discusses the importance of monitoring gut barrier integrity and suggests that certain markers can help detect changes early. This implies that safety assessments are crucial, but no direct human safety data is available from the provided studies.12345
How does the IPD Probe for Gut Permeability treatment differ from other treatments for gut permeability?
The IPD Probe for Gut Permeability is unique because it offers a minimally invasive way to measure gut permeability in real-time using gut potential difference (GPD) measurement, unlike traditional dual sugar absorption tests that are less precise and harder to use in certain populations like infants. This method allows for localized assessment of gut permeability, which can help identify different disease severities or pathologies.24678
What data supports the effectiveness of the IPD Probe treatment for gut permeability?
The research on a minimally invasive probe for gut permeability suggests it can provide real-time localized evaluation, which may offer advantages over traditional methods like the dual sugar absorption tests. This could potentially improve the assessment of gut permeability in various conditions, including inflammatory bowel diseases.2391011
Who Is on the Research Team?
Guillermo Tearney, M.D, PhD.
Principal Investigator
Massachusetts General Hospital
Are You a Good Fit for This Trial?
This trial is for healthy adults aged 18-60 who can consent and fast for at least 8 hours. It's not suitable for those with respiratory diseases, nasal steroid use, gastric emptying delays, alcoholism, certain medication uses (like clotting impairments or mast cell stabilizers), recent antibiotics use, liver diseases, galactosemia, uncontrolled diabetes, lactation due to pregnancy or any contraindications to nasopharyngeal procedures.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Procedure
Participants undergo the trans-nasal IPD probe procedure to measure intestinal potential difference and image quality
Follow-up
Participants are monitored for safety and effectiveness after the procedure
What Are the Treatments Tested in This Trial?
Interventions
- IPD Probe via TNIT
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts General Hospital
Lead Sponsor