Treatment for Lymphoma

Phase-Based Estimates
Children's Hospital Orange County, Orange, CA
Lymphoma+7 More
< 65
All Sexes
Eligible conditions

Study Summary

This study is evaluating whether a drug called Ixazomib may help treat multiple myeloma.

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Eligible Conditions

  • Lymphoma
  • Leukemia, Lymphoid
  • Leukemia, Lymphocytic, Acute, L1
  • Lymphoma, Diffuse
  • Leukemia
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Lymphoma, Non-Hodgkin
  • ALL, Childhood
  • Lymphoblastic Lymphoma, Childhood
  • Lymphoblastic Leukemia, Acute, Childhood

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome in patients with Lymphoma. Measurement will happen over the course of 5 weeks.

5 weeks
Phase 1: Dose limiting toxicity (DLT) during block 1 of chemotherapy

Trial Safety

Trial Design

1 Treatment Groups


This trial requires 31 total participants across 1 different treatment groups

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.

ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 5 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 5 weeks for reporting.

Closest Location

Children's Hospital Orange County - Orange, CA

Eligibility Criteria

This trial is for patients born any sex aged 65 and younger. You must have received 1 prior treatment for Lymphoma or one of the other 7 conditions listed above. There are 10 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Performance Level Karnofsky ≥ 50% for patients > 16 years of age and Lansky ≥ 50% for patients ≤ 16 years of age.
Phase 2
Age Patients must be ≤21 years of age at the time of enrollment.
Phase 1 - Initial enrollment will be restricted to patients < 18 years of age until 9 such patients are enrolled
Phase 2 - Initial enrollment will be restricted to patients < 18 years of age until 6 such patients are enrolled
Diagnosis Patients must have a diagnosis of relapsed/refractory ALL or LLy with or without extramedullary disease (including CNS2 and CNS3). Patient with mixed phenotype ALL or mature B (Burkitt-like) leukemia are not eligible.
Patients with ALL must have ≥ 5% blasts by morphology.
Patients with LLy must have measurable disease documented by clinical, radiologic or histologic criteria
Prior Therapy A. Prior therapeutic attempts
Phase 1 - Any patients with relapsed/refractory ALL or LLy

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for lymphoma?

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These are used to treat the cancer. Common therapies include radiation therapy, chemotherapy, targeted therapy, and surgery. Radiation therapy is used to shrink lymphoma tumors to reduce the risk of recurrence. Chemotherapy is used to treat any residual cancer cells. Targeted therapy or immunotherapy is used in rare cases when more effective methods are not available or work poorly in certain circumstances. Surgery is a treatment option in cases with tumors or lymph nodes that cannot be physically or surgically removed, or when malignant cells are present. Chemotherapy is often used before surgery and radiation therapy and to reduce the effects of the surgery or radiation therapy. Surgery and chemotherapy are often combined to treat some types of lymphomas.

Unverified Answer

What causes lymphoma?

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Nearly all lymphomas are linked to immune dysfunction, because either the immune system fails to recognize the immune system's own products as foreign and attack these cells as dangerous invaders, or the immune system is unable to kill them because of damage caused from previous infections and aging. The underlying immune dysfunction leads to the development of lymphoma in two ways: by creating a favorable environment for its growth through inflammation-driven immune cell infiltration, and by triggering the development of a tumor by the production of cytokines that, over time, activate and encourage further proliferation of the tumors' cells that invade the lymphatic vessels of the individual, where they are transported around the lymph nodes and are then eliminated by cellular defenses.

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How many people get lymphoma a year in the United States?

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Lymphoma affects about 100 people a day in the United States. Nearly one in five adults with lymphoma have mycosis fungoides. A minority of lymphomas occur in children. It is important that these patients receive all the needed and appropriate treatment.

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What is lymphoma?

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Lymphoma is a type of cancer that develops from the lymphatic system. It is rare for the lymph nodes to form the first symptom of lymphoma, but it can occur at any size on a lymphadenectomy specimen. The three most common forms of lymphoma in children are B-Cell precursor lymphoblastic lymphoma, non-Hodgkin's lymphoma, and the leukemia types B-Cell lymphoma, T-Cell lymphoma, and Hodgkin's lymphoma.\n

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Can lymphoma be cured?

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While lymphoma is treated with drugs and surgical techniques, and while some patients feel that their symptoms have improved or been alleviated after treatment, they are at no guarantee of a cure. Moreover, while there have been and continue to be many reported successes, other patients have died or become too ill to receive any treatment. Therefore, the question remains for the clinician, patient, and oncologist, whether a cure exists after the diagnosis of the cancer. As with many other diseases, patients must rely on our knowledge in the field of basic scientific research to determine possible cures. Further investigation into the feasibility of a cure is needed before these conclusions can be made.

Unverified Answer

What are the signs of lymphoma?

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An enlarged lymph node is the first sign of lymphoma. Other signs may include a swollen neck, chest or abdomen masses, and tiredness. An enlarged liver is a signs of hepatitis. A bone marrow problem can be diagnosed when the white blood cell count is low. Other signs of lymphoma include high levels of Bence Jones protein.

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What are the chances of developing lymphoma?

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This is a significant question given the importance of lymphoma to a person's wellbeing and is answered by: (1) a risk that is affected by family history as well as other aspects of an employee's life such as: smoking, exposure to and intake of environmental exposures, etc. (cite in text); (2) a low risk for development of lymphoma on average, but there are many patients who have never had lymphoma, yet have done so later. (cite in text) This is because of many confounding factors that affect the risk of cancer, which are often hard to identify due to the many factors that have to be considered.

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What is the average age someone gets lymphoma?

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In a recent study, findings found that the average age for lymphoma occurrence is 7.5 years old. No sex or race difference was found between genders although lymphomas were more common in males than in females. For young adults, lymphoma incidence increased significantly and then decreased. For people in their 20s and 30s, the annual increase in incidence was much higher compared to younger patients. These statistics demonstrate significant heterogeneity and should be considered when planning a lymphoma screening program.

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What are the latest developments in treatment for therapeutic use?

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A variety of chemotherapy drugs and monoclonal antibody targeting CD20 are currently in use or are undergoing human clinical trials for treatment of canine lymphoma. The use of radiation therapy for treatment of canine lymphoma deserves attention and study. A better understanding of how the process of malignant transformation can occur with the use of radiation therapy may contribute to improvements in therapeutic control of malignant tumors in both humans and dogs, and may ultimately translate into improved survival for patients with cancers in the same region of the body.

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Have there been any new discoveries for treating lymphoma?

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Since the mid-1980s there have been new treatments developed, like rituximab and various monoclonal antibodies, which are used in the treatment of B-cell lymphomas. There has also been an increased use of other innovative drugs to treat patients with all types of lymphomas, like gemtuzumab ozogamicin, which has been shown to be especially effective in treating follicular lymphoma and mantle cell lymphoma. In the future, other drugs for patients with lymphoma are very likely to be discovered or developed.

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What is the primary cause of lymphoma?

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The first question that doctors ask when someone has lymphoma is: “Is it a benign or malignant disease”? Doctors' opinions and experience as well as data from the literature suggest that ~90% of people are suffering from a malignant disease.

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Is treatment typically used in combination with any other treatments?

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Patients frequently received one or more treatments as part of their routine care, but little is known about which treatments are commonly combined. For patients with indolent disease, treatment-specific concerns about potential side effects may need to be considered when designing treatment regimens.

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