Lenalidomide +/- Ixazomib + Dexamethasone for Multiple Myeloma
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial compares the effectiveness of lenalidomide alone to a combination of lenalidomide, ixazomib citrate, and dexamethasone in patients with multiple myeloma that persists after a stem cell transplant. The drugs help the immune system fight cancer, stop cancer cells from growing, and kill them. Lenalidomide, a derivative of thalidomide, has been shown to be effective in combination with dexamethasone for treating multiple myeloma.
Who Is on the Research Team?
Andrzej Jakubowiak, MD, PhD
Principal Investigator
University of Chicago
Are You a Good Fit for This Trial?
This trial is for multiple myeloma patients with residual disease after a donor stem cell transplant. They must have been on lenalidomide maintenance for 3-4 months, have measurable residual disease, and proper organ function. Women of childbearing potential and men must agree to effective contraception methods. Exclusions include uncontrolled conditions like heart issues or diabetes, recent infections or surgeries, other cancer treatments within 30 days, certain drug allergies, severe neuropathy, CNS involvement, and QTc >470 msec.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either lenalidomide alone or in combination with ixazomib citrate and dexamethasone for 12 courses, each lasting 28 days
Follow-up
Participants are monitored for safety and effectiveness after treatment completion
What Are the Treatments Tested in This Trial?
Interventions
- Dexamethasone
- Ixazomib Citrate
- Lenalidomide
Dexamethasone is already approved in European Union, United States, Canada, Japan for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Chicago
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
Multiple Myeloma Research Foundation
Collaborator