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TMS for Spatial Navigation

N/A
Recruiting
Led By Travis E Baker
Research Sponsored by Rutgers, The State University of New Jersey
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 0 (day of testing)
Awards & highlights

Study Summary

This trial will examine how transcranial magnetic stimulation (TMS) affects brain activity & spatial processing during goal-directed navigation tasks. Results may show how TMS affects task performance & spatial encoding of rewards.

Who is the study for?
This trial is for adults aged 18-55 with stable mental and physical health, who haven't had substance abuse treatment in the last month. Participants must not be pregnant, have a history of significant brain disorders or metal implants that affect MRI scans, and should be able to follow study procedures.Check my eligibility
What is being tested?
The trial tests how Transcranial Magnetic Stimulation (TMS) affects spatial processing during virtual navigation tasks. It compares active TMS pulses against sham (placebo) pulses on the parietal cortex to see if they influence spatial memory and decision-making.See study design
What are the potential side effects?
Possible side effects of TMS may include discomfort at the stimulation site, headache, lightheadedness, or seizures; however, these are generally rare. The sham procedure is designed to mimic TMS without active stimulation and typically has fewer side effects.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 0 (day of testing)
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 0 (day of testing) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Event-related Brain Oscillation: Right Posterior Theta
Spatial Recall performance

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Active single-pulse rTMSExperimental Treatment1 Intervention
For the first TMS session, participants will receive a single TMS pulse during the phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined parietal target for a total of 300 pulses. For the second TMS session, participants will receive single pulse TMS during the phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined parietal target for a total of 200 pulses.
Group II: Active 10-Hz rTMSExperimental Treatment1 Intervention
For the first TMS session, participants will receive 10-Hz repetitive TMS (rTMS) delivered at 110% of participants' resting motor threshold over the predefined parietal target for a total of 2250 pulses. For the second TMS session, participants will receive single pulse TMS during the phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined parietal target for a total of 200 pulses.
Group III: Sham 10-Hz rTMSPlacebo Group1 Intervention
Identical parameters of the active 10-Hz rTMS group will be applied to the SHAM group with the exception that the TMS coil will be flipped 180º to mimic auditory stimulation.
Group IV: Sham single-pulse rTMSPlacebo Group1 Intervention
Identical parameters of the active single-pulse rTMS group will be applied to the SHAM group with the exception that the TMS coil will be flipped 180º to mimic auditory stimulation.

Find a Location

Who is running the clinical trial?

Rutgers, The State University of New JerseyLead Sponsor
429 Previous Clinical Trials
64,172 Total Patients Enrolled
Travis E BakerPrincipal InvestigatorRutgers University

Media Library

Active single-pulse rTMS Clinical Trial Eligibility Overview. Trial Name: NCT05801861 — N/A
Spatial Navigation Research Study Groups: Active single-pulse rTMS, Active 10-Hz rTMS, Sham 10-Hz rTMS, Sham single-pulse rTMS
Spatial Navigation Clinical Trial 2023: Active single-pulse rTMS Highlights & Side Effects. Trial Name: NCT05801861 — N/A
Active single-pulse rTMS 2023 Treatment Timeline for Medical Study. Trial Name: NCT05801861 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this medical investigation open to individuals aged below sixty?

"This medical study seeks participants under the age of 55 and above legal adulthood."

Answered by AI

Is it possible for me to become part of this research program?

"The prerequisites to enroll in this project are the ability to navigate one's environment and age between 18-55 years. Approximately 60 individuals are being sought for participation."

Answered by AI

How many individuals have been recruited for the trial thus far?

"Affirmative. According to the clinicaltrials.gov repository, this investigation is actively searching for participants. It was first posted on March 24th 2023 and most recently edited on that same day. Sixty people must be recruited from a single medical centre in order for it to continue its progress."

Answered by AI

Are there current opportunities for individuals to enroll in this experiment?

"Affirmative. According to the clinical trial's page on clinicialtrials.gov, this medical study is presently seeking participants. It was initially posted on March 24th 2023 and has been recently modified in the same month. This research endeavour requires 60 individuals from one location to participate."

Answered by AI

Who else is applying?

What site did they apply to?
Rutgers University - Newark
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Modulating Goal-directed Navigation Using Noninvasive Brain Stimulation
Travis Baker, PhD 2023. "Modulating Goal-directed Navigation Using Noninvasive Brain Stimulation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05801861.
All > Transcranial Magnetic Stimulation
~33 spots leftby Aug 2025
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