TMS for Depression
(SCC-TMS Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, it mentions that participants must have failed to respond to at least two different classes of antidepressant medications and augmentation therapies, which suggests that continuing current medications might be allowed.
What data supports the effectiveness of the treatment Transcranial Magnetic Stimulation (TMS) for depression?
Research shows that Transcranial Magnetic Stimulation (TMS) is an effective treatment for major depression, with studies documenting improvements in patient-rated and clinician-rated outcomes. TMS has also been shown to improve quality of life in patients with depression who do not respond to medication.12345
Is transcranial magnetic stimulation (TMS) safe for humans?
How is the treatment TMS for depression different from other treatments?
Transcranial Magnetic Stimulation (TMS) is unique because it is a non-invasive treatment that uses magnetic fields to stimulate nerve cells in the brain, which can help improve symptoms of depression. Unlike medications, TMS does not involve taking drugs and is often used when other treatments, like antidepressants, have not been effective.37101112
What is the purpose of this trial?
This study will investigate the feasibility, safety, and tolerability of administering repetitive Transcranial magnetic stimulation(TMS) at frequencies other than standard 10 Hz. This study will enroll 10 subjects who will undergo one quantitative electroencephalograph, one TMS procedure to determine the appropriate frequency and intensity for treatment, weekly mood/symptom assessments, and up to 30 TMS treatments. Subjects will be asked to participate for up to 6 weeks.
Eligibility Criteria
This trial is for adults aged 18-65 with severe Major Depressive Disorder who haven't improved after trying at least two different antidepressants and psychotherapy. Participants must be able to commit to the study schedule and visits, but can't join if they have a high seizure risk, certain neurological conditions, scalp infections, mental incapacity, or magnetic-sensitive implants near the treatment area.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Frequency Determination
Subjects undergo QEEG and motor threshold determination to establish individual TMS frequency
Treatment
Participants receive up to 30 TMS treatments at individualized frequencies, with weekly mood/symptom assessments
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Transcranial magnetic Stimulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor