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Sealant

Tails for Sealant (COES Trial)

Phase 1

Recruiting

Research Sponsored by University of Southern California

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

COES Trial Summary

This trial aims to compare the longevity of sealants with a bonding agent cured before placement versus those with an uncured bond in pediatric dental patients. The study will be conducted by USC graduate pediatric personnel at

Who is the study for?

This trial is for pediatric patients who need dental sealants to prevent tooth decay. The study will be conducted by USC graduate pediatric personnel at specific clinics, and participants must have teeth suitable for sealant application.Check my eligibility

What is being tested?

The COES study tests the longevity of two methods of applying a dental sealant called Ultradent Ultra Seal XT Plus: one with bonding agent cured before placing the sealant versus one with uncured bond. It's a controlled test where each child gets both treatments on different halves of their mouth.See study design

What are the potential side effects?

Dental sealants are generally safe, but there might be rare side effects like allergic reactions or sensitivity in the treated area. This study primarily focuses on how long the sealants last rather than side effects.

COES Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Sealant Longevity

Secondary outcome measures

Caries

Molar hypomineralization

COES Trial Design

2Treatment groups

Experimental Treatment

Group I: TailsExperimental Treatment1 Intervention

Tails indicates the LEFT side of the mouth WILL be cured prior to sealant placement. The right side of the mouth will not have bond cured prior to sealant placement.

Group II: HeadsExperimental Treatment1 Intervention

Heads indicates the RIGHT side of mouth WILL be cured prior to sealant placement. The left side of the mouth will have bond and sealant cured together after.

Do I qualify?Apply below to find out

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of Southern CaliforniaLead Sponsor

906 Previous Clinical Trials

1,595,959 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Which category of individuals would be considered ideal candidates for participation in this clinical trial?

"To be considered for inclusion in this study, candidates must exhibit the presence of a sealing agent and fall within the age range of 5 to 14 years. The research endeavor aims to enroll approximately 217 participants."

Answered by AI

Are there any available openings for participants in this ongoing medical study?

"As indicated on clinicaltrials.gov, this research study is currently enrolling participants. This trial was initially shared on February 23rd, 2024, and the most recent update was made on March 26th of the same year."

Answered by AI

Are participants above the age of 35 considered suitable candidates for this research study?

"Enrollment is open to individuals over 5 years of age but under the age of 14."

Answered by AI

What are the potential risks of using Heads for individuals?

"Given the preliminary nature of this trial as Phase 1, our team at Power rates Heads with a safety score of 1 due to scant data supporting both its efficacy and safety."

Answered by AI

What is the current number of individuals actively participating in this clinical trial?

"Affirmative. Information from clinicaltrials.gov indicates that this research study is presently seeking volunteers. The trial was initially listed on February 23, 2024, and its most recent update was on March 26, 2024. A total of 217 participants are sought at one designated site for this investigation."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

COES: Curing Order Effects on Sealants

Catherine Pham 2024. "COES: Curing Order Effects on Sealants". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06342258.

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