PRF for Wound Healing
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a treatment called Platelet-rich fibrin (PRF) to determine its effectiveness in healing after tooth extraction, especially compared to using only a collagen plug. The researchers aim to discover if PRF, along with a person's age, enhances healing and regeneration. Individuals needing a molar extraction due to cavities, gum disease, or a broken tooth, and who plan to receive an implant later, might be suitable candidates. As an unphased trial, this study provides a unique opportunity to contribute to scientific understanding and potentially benefit from innovative healing methods.
Will I have to stop taking my current medications?
The trial requires that you do not take certain medications that affect bone healing, like bisphosphonates, long-term NSAIDs, or steroids. If you are on these medications, you may need to stop them to participate.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that platelet-rich fibrin (PRF) is generally safe for people. Studies have found that PRF can aid wound healing and support bone growth after tooth extraction. No major reports of negative effects have emerged from its use, making it a safe choice for tissue and bone healing. The treatment involves placing a PRF plug in the socket after tooth removal, which aids healing without major side effects.12345
Why are researchers excited about this trial?
Researchers are excited about using platelet-rich fibrin (PRF) for socket preservation because it introduces a natural, regenerative approach to wound healing. Unlike the standard treatments that typically rely on synthetic materials like collagen plugs alone, PRF harnesses the body's own platelets to accelerate tissue repair and regeneration. This method not only enhances the healing process but may also reduce the risk of infection and improve overall outcomes for patients following tooth extractions.
What evidence suggests that PRF is effective for wound healing?
Research has shown that platelet-rich fibrin (PRF), which participants in this trial may receive, aids healing after dental procedures. In about two-thirds of studies, PRF significantly reduced pain in the initial days following tooth extraction. It also accelerated gum healing and improved surgical wound closure. PRF has protected the bone supporting teeth, proving useful for maintaining area health after tooth removal. By speeding up healing and reducing discomfort, PRF offers promising benefits for individuals undergoing dental surgeries.16789
Who Is on the Research Team?
Muhammad Saleh, BDS, MSD
Principal Investigator
University of Michigan
Are You a Good Fit for This Trial?
This trial is for individuals aged 20-80 needing tooth extractions due to caries, periodontal disease, or other reasons and interested in dental implants. Participants should have non-infected sockets with sufficient bone thickness and good oral hygiene. Those with compromised immune systems, active cancer treatments, severe infections, uncontrolled diabetes, or certain medication use are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo tooth extraction followed by placement of a collagen plug with or without platelet-rich fibrin
Follow-up
Participants are monitored for wound healing and alveolar ridge dimension changes
What Are the Treatments Tested in This Trial?
Interventions
- Socket Preservation
Trial Overview
The study investigates the impact of Platelet-Rich Fibrin (PRF) on wound healing after tooth extraction (socket preservation), particularly how age influences the regenerative benefits of PRF during this process.
How Is the Trial Designed?
2
Treatment groups
Active Control
Placebo Group
Following extraction, a Platelet-rich fibrin plug will be placed in the extraction socket and covered with a collagen plug.
Collagen plug only
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Michigan
Lead Sponsor
Citations
Efficacy of platelet-rich fibrin in promoting the healing ...
Results: 66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1-3 days after tooth ...
2.
journalimplantdent.springeropen.com
journalimplantdent.springeropen.com/articles/10.1186/s40729-021-00393-0Efficacy of platelet-rich fibrin in promoting the healing of ...
66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1–3 days after tooth extraction. Soft ...
Efficacy of Platelet-Rich Fibrin in Preserving Alveolar Ridge ...
Numerous studies have demonstrated that PRF can hasten epithelial closure following surgery, improve soft tissue healing, and lessen discomfort ...
Platelet Rich Fibrin (PRF) in Socket Preservation Technique
The aim of this randomized-controlled clinical trial is to suggest that platelet rich fibrin (PRF) as solely grafting material may be a valid tool in this ...
5.
bmcoralhealth.biomedcentral.com
bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-025-06238-1The efficacy of platelet-rich fibrin (PRF) in post-extraction hard ...
The analysis showed that PRF significantly improved soft tissue healing and reduced the incidence of AO. While PRF helped reduce pain, the ...
The effect of recurrent application of concentrated platelet ...
Platelet-rich fibrin (PRF) is commonly used for ridge preservation following tooth extraction. However, its effectiveness diminishes over a ...
Influence of platelet-rich fibrin on wound healing and bone ...
PRF is significantly better in promoting soft tissue healing and also hastens bone formation in extraction socket. PRF may be recommended as a valuable material ...
The Assessment of the Usefulness of Platelet-Rich Fibrin in ...
The main subject of this research was the use of PRF in dental surgery aimed at preventing changes in alveolar height and width after tooth extraction.
Efficacy of the application of leukocyte and platelet‐rich ...
Leukocyte and platelet-rich fibrin (L-PRF) has been showing to potentially promote bone and tissue regeneration during wound healing. Therefore, ...
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