Bariatric Surgery for Obesity
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using beta blockers.
What data supports the effectiveness of the treatment Circadian Clock Alignment, Circadian Clock Control for obesity?
Research suggests that bariatric surgery, which includes changes in circadian clock alignment, can lead to significant weight loss and improve metabolic health by altering eating patterns and reprogramming the body's internal clock, especially in the liver. This indicates that aligning the circadian clock may enhance the benefits of bariatric surgery for obesity.12345
Is bariatric surgery generally safe for humans?
Bariatric surgery is considered the most effective long-term treatment for severe obesity, leading to significant weight loss and improvements in obesity-related health issues. Studies suggest it is generally safe, with no significant negative effects on behavior or core circadian rhythms observed in research involving mice.12346
How does bariatric surgery differ from other treatments for obesity?
Bariatric surgery is unique because it not only restricts food intake and alters digestion but also causes significant changes in hormones that regulate hunger and energy balance, leading to long-term weight loss and improvement in conditions like type 2 diabetes. Unlike other treatments, it combines both restrictive and malabsorptive techniques, which are more effective than purely restrictive methods like gastric banding.7891011
What is the purpose of this trial?
The purpose of this study is to understand how daily rhythms of behavior affect the expression of genes in fat cells, and how these daily cycles affect the way fat cells respond to insulin (a hormone that controls blood sugar levels) before and after bariatric surgery.
Research Team
Matthew Brady, PhD
Principal Investigator
University of Chicago
Eligibility Criteria
This trial is for obese women aged 18-55 with a BMI over 40, scheduled for bariatric surgery at the University of Chicago. It's not open to those allergic to lidocaine, with uncontrolled high blood pressure, recent surgery or clinical study participation, lactating or post-menopausal women, men, beta blocker users, pregnant individuals, or anyone with certain serious illnesses.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Pre-Surgery Intervention
Participants undergo circadian clock alignment intervention or control conditions 3 nights before bariatric surgery
Bariatric Surgery
Participants undergo bariatric surgery
Post-Surgery Monitoring
Participants are monitored for changes in insulin sensitivity and gene expression in adipocytes
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Circadian Clock Alignment
- Circadian Clock Control
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Chicago
Lead Sponsor