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Bariatric Surgery for Obesity

N/A
Waitlist Available
Led By Matthew Brady, PhD
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18-55 years old
Female
Must not have
Diagnosed with a systemic illness, including heart, renal, liver, or malignant disease
Uncontrolled hypertension (blood pressure greater than 140 mmHg systolic and 90 mmHg diastolic without medication)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

Summary

This trial will help understand how daily rhythms affect gene expression in fat cells and how those cells respond to insulin before and after weight loss surgery.

Who is the study for?
This trial is for obese women aged 18-55 with a BMI over 40, scheduled for bariatric surgery at the University of Chicago. It's not open to those allergic to lidocaine, with uncontrolled high blood pressure, recent surgery or clinical study participation, lactating or post-menopausal women, men, beta blocker users, pregnant individuals, or anyone with certain serious illnesses.Check my eligibility
What is being tested?
The study aims to understand how daily behaviors influence gene expression in fat cells and insulin response before and after bariatric surgery by focusing on circadian clock control and alignment.See study design
What are the potential side effects?
While this trial focuses on observation rather than medication side effects per se, potential risks may include typical surgical complications from bariatric procedures such as infection or adverse reactions to anesthesia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 55 years old.
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I am female.
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I am a woman aged 18-55 and not obese.
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I am considered obese based on medical standards.
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My BMI is over 40, indicating I am severely obese.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have been diagnosed with a disease affecting my heart, kidneys, liver, or cancer.
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My blood pressure is controlled and below 140/90 mmHg without medication.
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I have gone through menopause.
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I am male.
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I am currently taking beta blockers.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in insulin sensitivity

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Circadian Clock Alignment - High BMIExperimental Treatment1 Intervention
Subjects will come to the Sleep Lab three nights before their bariatric surgery procedure for an intervention that will align their central circadian clock. The intervention includes eating meals and snacks at fixed times and having lights off at a specific time at night and lights on at a specific time in the morning.
Group II: Circadian Clock Control - High BMIActive Control1 Intervention
Subjects will not come to the Sleep Lab and will live normally at home with no changes to their meal, sleep or wake times.
Group III: Circadian Clock Control - Low BMIActive Control1 Intervention
Subjects will not come to the Sleep Lab and will live normally at home with no changes to their meal, sleep or wake times.

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,018 Previous Clinical Trials
734,533 Total Patients Enrolled
14 Trials studying Obesity
1,909 Patients Enrolled for Obesity
Matthew Brady, PhDPrincipal InvestigatorUniversity of Chicago

Media Library

Circadian Clock Alignment Clinical Trial Eligibility Overview. Trial Name: NCT04242524 — N/A
Obesity Research Study Groups: Circadian Clock Alignment - High BMI, Circadian Clock Control - High BMI, Circadian Clock Control - Low BMI
Obesity Clinical Trial 2023: Circadian Clock Alignment Highlights & Side Effects. Trial Name: NCT04242524 — N/A
Circadian Clock Alignment 2023 Treatment Timeline for Medical Study. Trial Name: NCT04242524 — N/A
Obesity Patient Testimony for trial: Trial Name: NCT04242524 — N/A
~10 spots leftby Dec 2025