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Bariatric Surgery for Obesity

N/A
Recruiting
Led By Matthew Brady, PhD
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18-55 years old
Female
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

Study Summary

This trial will help understand how daily rhythms affect gene expression in fat cells and how those cells respond to insulin before and after weight loss surgery.

Who is the study for?
This trial is for obese women aged 18-55 with a BMI over 40, scheduled for bariatric surgery at the University of Chicago. It's not open to those allergic to lidocaine, with uncontrolled high blood pressure, recent surgery or clinical study participation, lactating or post-menopausal women, men, beta blocker users, pregnant individuals, or anyone with certain serious illnesses.Check my eligibility
What is being tested?
The study aims to understand how daily behaviors influence gene expression in fat cells and insulin response before and after bariatric surgery by focusing on circadian clock control and alignment.See study design
What are the potential side effects?
While this trial focuses on observation rather than medication side effects per se, potential risks may include typical surgical complications from bariatric procedures such as infection or adverse reactions to anesthesia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 55 years old.
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I am female.
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I am a woman aged 18-55 and not obese.
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I am considered obese based on medical standards.
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My BMI is over 40, indicating I am severely obese.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in insulin sensitivity

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Circadian Clock Alignment - High BMIExperimental Treatment1 Intervention
Subjects will come to the Sleep Lab three nights before their bariatric surgery procedure for an intervention that will align their central circadian clock. The intervention includes eating meals and snacks at fixed times and having lights off at a specific time at night and lights on at a specific time in the morning.
Group II: Circadian Clock Control - High BMIActive Control1 Intervention
Subjects will not come to the Sleep Lab and will live normally at home with no changes to their meal, sleep or wake times.
Group III: Circadian Clock Control - Low BMIActive Control1 Intervention
Subjects will not come to the Sleep Lab and will live normally at home with no changes to their meal, sleep or wake times.

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,004 Previous Clinical Trials
819,695 Total Patients Enrolled
14 Trials studying Obesity
1,904 Patients Enrolled for Obesity
Matthew Brady, PhDPrincipal InvestigatorUniversity of Chicago

Media Library

Circadian Clock Alignment Clinical Trial Eligibility Overview. Trial Name: NCT04242524 — N/A
Obesity Research Study Groups: Circadian Clock Alignment - High BMI, Circadian Clock Control - High BMI, Circadian Clock Control - Low BMI
Obesity Clinical Trial 2023: Circadian Clock Alignment Highlights & Side Effects. Trial Name: NCT04242524 — N/A
Circadian Clock Alignment 2023 Treatment Timeline for Medical Study. Trial Name: NCT04242524 — N/A
Obesity Patient Testimony for trial: Trial Name: NCT04242524 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this investigation open to those of more advanced age?

"For this clinical trial, the age range for participating candidates is between 18 and 55 years old."

Answered by AI

May I register for participation in this clinical examination?

"This medical trial is enrolling 82 people who have been diagnosed with metabolic syndrome and are aged between 18 to 55 years."

Answered by AI

How many test subjects are participating in this experiment?

"Affirmative. The clinicaltrials.gov portal demonstrates that this study was inaugurated on March 26th 2015 and is still actively recruiting participants as of January 27 2022, requiring 82 patients at a single medical facility."

Answered by AI

Are there any available slots for individuals to join this clinical experiment?

"Affirmative. Clinicaltrials.gov indicates that this clinical trial is actively recruiting candidates, with 82 patients sought from 1 centre since it was initially posted on March 26th 2015 and updated as recently as January 27th 2022."

Answered by AI

Who else is applying?

What state do they live in?
Illinois
How old are they?
18 - 65
What site did they apply to?
University of Chicago
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I am obesity. I have complications from being on over pre diabetes. I have tried weight loss gummies exercises, dieting pills. I will lose and gain back what I lost.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
The Impact of Bariatric Surgery on Adipocyte Metabolism
2015. "The Impact of Bariatric Surgery on Adipocyte Metabolism". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04242524.
All > Metabolic Syndrome
~12 spots leftby Dec 2025
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