CLINICAL TRIAL

Guanfacine ER for Alcoholism

Recruiting · 18+ · All Sexes · New Haven, CT

This study is evaluating whether guanfacine may help reduce alcohol consumption in individuals who are dependent on alcohol.

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About the trial for Alcoholism

Eligible Conditions
Alcoholism · Alcohol Use · Drinking Behavior · Alcohol Drinking

Treatment Groups

This trial involves 2 different treatments. Guanfacine ER is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Guanfacine ER
DRUG
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Placebo
OTHER

Eligibility

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
You are aged 21 to 70 years. show original
You must be able to read and write English. show original
You have had a problem with alcohol use for at least 6 months. show original
Drinking criteria: Males Drinks more than 14 drinks per week and exceeds 4 drinks per day at least twice per week; Females Drinks > more than drinks per week and exceeds 3 drinks per day at least twice per week. Must meet drinking criteria during a consecutive 30 day period prior to baseline;
Laboratory sessions will be scheduled such that subjects will not have major responsibilities on the following day which might limit drinking during the self administration session (e.g., job interview, exam);
You are able to take oral medications and willing to adhere to medication regimen. show original
indicate willingness to cut down on drinking during the treatment period.
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 120 minutes
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 120 minutes.
View detailed reporting requirements
Trial Expert
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- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Guanfacine ER will improve 1 primary outcome in patients with Alcoholism. Measurement will happen over the course of 120 minutes.

Alcohol Consumption
120 MINUTES
Means mls of alcohol consumed for guanfacine ER and placebo groups during 120 minute alcohol self administration sessions with personalized stress imagery vs stimulation imagery vs neutral imagery taking place as close to Week 0 of steady state as possible comparing females to males.

Who is running the study

Principal Investigator
S. M.
Prof. Sherry McKee, Professor
Yale University

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can alcoholism be cured?

Even with good treatment, many patients still go on to have significant alcohol related problems. Many patients, especially female alcoholics, may recover and be able to drink relatively moderate amounts of alcohol. These patients may be able to have a good social and occupational life. The ability of an alcoholic to avoid being dependent on alcohol will depend on the extent of their addiction. Those with the strongest addictions will be the most likely to drink very large quantities at a single chance, but even those with addiction tend to drinking less often and may eventually stop. However, they will still have considerable alcohol-related risk of problem drinking.

Anonymous Patient Answer

What is alcoholism?

Alcoholism is a disorder of ethanol (alcohol) consumption and may impact many components of health by mechanisms that are unrelated to the effects of ethanol use and/or abuse.

Anonymous Patient Answer

How many people get alcoholism a year in the United States?

About 4.4 million to 14.7 million people in the United States were estimated to be an alcohol-dependent individual in 1995. There is a large diversity in alcohol consumption patterns among those with problems (14.7%), who drink more than 7.2 grams per day of alcohol or more than 5 alcoholic beverages per day (6.9%); and those who drink less than 3.6 grams of alcohol or less than 2.5 alcoholic beverages per day (1.8%). These people can be categorized as either moderate-severe drinkers, binge drinkers, problem drinkers (people who can be categorized as both moderate-severe drinkers and binge drinkers) or light drinkers. In 1995, 4.4 million to 14.

Anonymous Patient Answer

What are common treatments for alcoholism?

Alcoholism affects about 15% of adults in the United States, and many of these patients do not receive adequate treatment. A major concern with alcoholism is its relation to cirrhosis. A minority of patients with cirrhosis may benefit from alcohol detoxification by abstinence or by lowering blood alcohol concentration with medications.

Anonymous Patient Answer

What are the signs of alcoholism?

Alcoholism is well known for its profound impact on many body systems and can result in serious damage to many organs in the body, and thus the signs of this disease are varied.\n

Anonymous Patient Answer

What causes alcoholism?

Alcoholism, which is defined as binge drinking and chronic alcohol use, has a complex etiology, and it can be difficult to determine the role of environment (i.e., genetics, psychosocial factors). This is a significant challenge to prevention efforts because the social environment plays an important role in determining vulnerability. The social milieu of alcoholism is influenced by both genetic and environmental factors. The influence of both the genetic and environmental factors on alcoholism onset and consequences may have a stronger effect in males than in females. As is true for most psychiatric disorders, the mechanisms of action are poorly understood because both genetic and environmental factors contribute to risk of disease.

Anonymous Patient Answer

What is the average age someone gets alcoholism?

For any specific disease, the age of onset is not necessarily predictable. Because most diseases (with the exception of dementia-related diseases) begin with symptoms of an undetected (preclinical) condition, a "disease onset age" is neither meaningful nor relevant but can still allow for the prediction, on a case-by-case basis, of how old a patient will be when signs and symptoms of a problem become evident. Of course, such "disease onset age" is a highly arbitrary measure of the onset of a disease and its symptoms, but unfortunately there are no better way to think about or measure disease onset than by age in general.

Anonymous Patient Answer

How serious can alcoholism be?

Alcoholism can in serious terms, or in cases of severe consequences, become an irreversible, chronic and possibly fatal illness. Alcoholics face the prospect of a chronic and possibly fatal illness. Alcoholism is a disease which is of particular concern for women. However, alcoholism can occur in men and women. [Power (https://www.withpower.com/clinical-trials/cognitive-behavioral-therapy) has made it possible to run studies that examine the relationship between the alcoholic's treatment and the patient. With power, it's possible to answer pertinent questions, such as the type of alcoholic, the amount of drinking he [or she] does, and the number of years the alcoholic has been drinking.

Anonymous Patient Answer

Have there been any new discoveries for treating alcoholism?

Until recently, the only way to treat alcoholic patients was to treat the alcohol dependency and then find individual counseling or a self-help group to help them manage their drinking problem. Since the 1990s, additional treatments have become available to manage alcohol intake and drinking behaviour and have been shown to improve patients' quality of life and quality of life of loved ones.

Anonymous Patient Answer

Does guanfacine er improve quality of life for those with alcoholism?

Guanfacine has some benefit to patients in reducing alcohol intake, however it also has negative side effects, which outweigh any positive impact on QOL. The negative effects of guanfacine on alcohol and QOL (even though only 5% of patients had reported this in the trial) highlight the need for more in depth consideration of the possible negative effects of guanfacine on QOL in patients with this addiction. This article is protected by copyright. All rights reserved.

Anonymous Patient Answer

What is the primary cause of alcoholism?

Recent findings of this meta-analysis do not support the hypothesis that alcoholism is caused by an organic brain defect. If it is not due to an organic brain defect, then the primary cause must be a psychological factor. In addition, the results of this meta-analysis imply that the current DSM definition of alcoholism is flawed without a specific definition of primary causation.

Anonymous Patient Answer

What does guanfacine er usually treat?

There is currently insufficient data for using Gua to treat alcohol intake. Further, Gua was effective in reducing the craving for alcohol. Gua has the potential benefit in treating alcohol-related disorders. However, further research is needed to test its efficacy in treating alcohol dependence and other alcohol disorders.

Anonymous Patient Answer
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