Migraine Medications for Tinnitus
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests two different medication combinations to help people with tinnitus. One group gets nortriptyline and topiramate, another gets verapamil and paroxetine. The goal is to see if these medications can reduce the stress and anxiety caused by tinnitus. Paroxetine has been studied previously for its potential to relieve tinnitus symptoms.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is the combination of Nortriptyline and Topiramate safe for humans?
The combination of Nortriptyline and Topiramate has been studied for migraine prevention, and while it can be effective, it may have side effects that vary among individuals. It's important to balance the potential benefits with the risk of adverse effects, and this should be discussed with a healthcare provider.12345
How does the drug combination of Nortriptyline + Topiramate and Verapamil + Paroxetine differ from other treatments for tinnitus?
This drug combination is unique because it combines medications typically used for migraines and depression, which may address both the neurological and psychological aspects of tinnitus. While no drugs are specifically approved for tinnitus, using these medications together could target multiple pathways involved in the condition, offering a novel approach compared to traditional treatments.678910
What data supports the effectiveness of the drug Nortriptyline + Topiramate for treating tinnitus?
Research suggests that nortriptyline, a component of the treatment, may help some patients with tinnitus, especially those with depression, although it does not directly reduce tinnitus severity. Additionally, similar antidepressants like amitriptyline have shown effectiveness in reducing tinnitus symptoms.711121314
Who Is on the Research Team?
Hamid R Djalilian, MD
Principal Investigator
Univeristy of California, Irvine
Are You a Good Fit for This Trial?
This trial is for adults aged 25-85 with moderate to severe tinnitus. Participants must be able to read and write English, attend study visits, and comply with medication regimens. Pregnant individuals, those with adverse reactions to the medications being tested or certain medical conditions are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either nortriptyline plus topiramate, verapamil plus paroxetine, or placebo for 8 weeks. Dosages may be increased weekly based on symptoms.
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Nortriptyline + Topiramate
- Placebo
- Verapamil + Paroxetine
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Irvine
Lead Sponsor