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Metformin XR for Preventing Multiple Myeloma
Study Summary
This trial will study whether metformin can help prevent patients with MGUS and SMM from developing multiple myeloma.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2016 Phase 4 trial • 532 Patients • NCT02252965Trial Design
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- Your AST and ALT levels must be less than 1.5 times the normal limit at the institution where you are being treated.I am 18 years old or older.Your bilirubin levels are within the normal range for the testing lab, unless you have Gilbert's Disease, in which case your direct bilirubin levels should be within the normal range.I was randomized to take metformin and can continue it for 6 more months after the main study period.My kidneys are functioning well enough to clear waste.Your blood sugar levels are not too high, with random glucose less than 160 mg/dL or fasting glucose less than 126 mg/dL.I am able to care for myself and perform daily activities.I am taking medication for diabetes.I don't have conditions that increase the risk of lactic acidosis and I drink less than 3 alcoholic drinks a day.My condition is high-risk smoldering myeloma according to the '20-2-20' criteria.I have a condition that affects how my body absorbs medication.You have been diagnosed or treated for another type of cancer during the study period.You do not show signs of specific symptoms related to multiple myeloma or Waldenstrom's macroglobulinemia as described in the provided information.You have experienced bad reactions to metformin in the past.I have been diagnosed with a higher-risk form of MGUS or low-risk SMM.
- Group 1: Metformin
- Group 2: Placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
To what extent is participant involvement in this trial?
"Affirmative. Clinicaltrials.gov attests that this clinical trial, which was initially made available on April 27th 2021, is currently seeking participants. The project seeks to recruit 80 patients from 7 distinct medical sites."
Is Metformin XR a safe and viable treatment option for patients?
"Our team at Power rated Metformin XR's safety a 2, as this is only in its second clinical trial phase and there has yet to be any evidence of efficacy."
What medical conditions might Metformin XR be a viable solution for?
"Metformin XR is most often employed to treat exercise-related issues, but can also assist with type 1 diabetes mellitus, diabetic ketoacidosis and polycystic ovary syndrome."
Has Metformin XR been previously tested in other scientific experiments?
"Currently, there are 170 Metformin XR studies in progress with 43 trials at the Phase 3 stage. Most of these clinical tests take place in Pittsburgh; however, 1903 other centres across the country have also launched investigations into this medication."
Are there any opportunities to enroll in this experiment right now?
"Per the data available on clinicaltrials.gov, this trial is actively searching for eligible participants. The study was initially announced on April 27th 2021 and has been amended most recently on October 3rd 2022."
How widespread is the implementation of this clinical trial?
"Seven medical centres are currently enrolling patients in this research endeavour, with the most prominent being Brigham and Women's Hospital located in Boston. Other clinical trial sites include Dana-Farber at Merrimack Valley in Methuen and Dana-Farber at NHOH in Londonderry, complemented by an additional seven locations."
Who else is applying?
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What portion of applicants met pre-screening criteria?
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