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Remdesivir for COVID-19 (I-SPY_COVID Trial)
I-SPY_COVID Trial Summary
This trial is looking for treatments that could help COVID-19 patients who are critically ill and need mechanical ventilation.
I-SPY_COVID Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.I-SPY_COVID Trial Design
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Who is running the clinical trial?
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- I am receiving care focused on my comfort.My doctor thinks I have a 50% or higher chance of passing away in the next six months due to my chronic conditions.My heart's pumping ability is very weak, or I have unstable chest pain.I am hospitalized and on high flow oxygen or intubated for COVID-19 treatment.I am not currently enrolled in any drug trials that need special approval.My liver is not functioning well, with a severe condition score.I haven't needed high flow oxygen or a ventilator for more than 5 days.I am at least 18 years old.I am currently on three or more medications to raise my blood pressure.I have had allergic reactions to drugs similar to the study medication.I am on dialysis for end-stage kidney disease or acute kidney injury.
- Group 1: Narsoplimab + Standard of Care (CLOSED)
- Group 2: Aviptadil + Standard of Care (CLOSED)
- Group 3: Cyproheptadine + Standard of Care (CLOSED)
- Group 4: Icatibant + Standard of Care (CLOSED)
- Group 5: Cenicriviroc + Standard of Care (CLOSED)
- Group 6: Control/Backbone - Remdesivir and Dexamethasone (CLOSED)
- Group 7: Cyclosporine + Standard of Care (CLOSED)
- Group 8: Imatinib (PENDING ACTIVATION)
- Group 9: IC14 + Standard of Care (CLOSED)
- Group 10: Imatinib + Standard of Care (CLOSED)
- Group 11: Dornase + Standard of Care (CLOSED)
- Group 12: Celecoxib/famotidine + Standard of Care (CLOSED)
- Group 13: Apremilast + Standard of Care (CLOSED)
- Approved for 20 Other Conditions - This treatment demonstrated efficacy for 20 other conditions.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
When will Remdesivir be cleared for general use?
"Remdesivir received a score of 2 because, while there is some evidence backing its safety, clinical efficacy has not yet been demonstrated."
What other scientific papers exist on Remdesivir?
"Remdesivir, which is currently in Phase 3 for 31 trials, has 140 ongoing clinical studies. The majority of these investigations are occurring out of Aurora, Colorado; however, there are a total of 2238 locations running Remdesivir clinical trials."
Is this study being conducted in various parts of the city?
"This study is being conducted at 29 sites across the country. For example, some of these locations include Kaiser LAMC in Los Angeles, Yale Cancer Center in New Haven, and Spectrum Health in Grand Rapids."
How many people are volunteering to participate in this test program?
"That is correct, the online information does specify that this clinical trial is presently looking for volunteers. The postings went up on 7/31/2020 and the most recent update was on 10/6/2022. They are hoping to get 1500 patients from 29 different locations."
What are the common conditions that Remdesivir is used to treat?
"Remdesivir is frequently used to treat lupus nephritis. However, it can also help patients with conditions like bulla, rejection, transplant, and muscle spasms."
Are there any available positions for participants in this experiment?
"That is correct, this trial is still open and recruiting patients. According to the listing on clinicaltrials.gov, the study was posted on 7/31/2020 and last edited on 10/6/2022. They are looking for 1500 participants from 29 different sites."
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
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