Toothpaste for Gum Disease
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you stop taking certain medications, such as antibiotics, anti-inflammatory drugs, anticoagulants, and medications that affect gum appearance or bleeding, at least one month before starting the study. If you regularly use anti-gingivitis treatments, you must also stop these at least one month prior to the trial.
What data supports the effectiveness of the treatment for gum disease?
Research shows that toothpaste containing stannous fluoride can help reduce gingivitis (gum inflammation) and plaque, which are common issues in gum disease. Additionally, stannous fluoride has been found to protect teeth enamel from acid damage and improve oral health by affecting the oral microbiome (the community of bacteria in the mouth).12345
Is stannous fluoride dentifrice safe for humans?
How is this toothpaste treatment for gum disease different from other treatments?
What is the purpose of this trial?
The primary objective of this study is to evaluate the effect of two experimental hops extract-containing dentifrices on gingivitis relative to a positive control 0.454% SnF2 dentifrice and a negative control dentifrice after 12 weeks of product use.
Research Team
All Sum Research
Principal Investigator
All Sum Research
Eligibility Criteria
This trial is for individuals with gingivitis or gum disease. Participants should be willing to use one of the three different toothpastes being tested over a period of 12 weeks. The specific eligibility criteria are not provided, but typically would include age range, general health status, and confirmation of gingivitis.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants use the assigned dentifrice for 12 weeks to assess its effect on gingivitis
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Sodium Fluoride Dentifrice
- Sodium monofluorophosphate dentifrice
- Stannous Fluoride Dentifrice
Find a Clinic Near You
Who Is Running the Clinical Trial?
Procter and Gamble
Lead Sponsor
Marc Pritchard
Procter and Gamble
Chief Marketing Officer since 2008
B.S. in Finance from Indiana University, Bloomington
Jon R. Moeller
Procter and Gamble
Chief Executive Officer since 2021
MBA from Cornell University, B.S. in Biology from Cornell University