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Deep Brain Stimulation for Depression
Study Summary
This trial will study the effects of DBS on the medial forebrain bundle to treat refractory depression in 20 patients.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- The person has a score of at least 21 on the first 17 items on the Hamilton Depression Rating Scale.I do not have any brain-related health issues like dementia.I have had depression for over 5 years with severe impacts or hospital visits.I have tried multiple depression treatments without success, including medications, therapy, and ECT.My depression has recurred 4+ times or lasted 2+ years, starting over 5 years ago.I've had surgery to target a specific area in my brain before.I have been diagnosed with severe depression.I am between 22 and 70 years old.I have tried multiple antidepressants, ECT, and psychotherapy without success.I have been on the same mental health medication for at least 6 weeks.My main diagnosis is depression, not schizophrenia, bipolar, or severe anxiety.I have had depression for over 5 years with severe impacts or multiple hospital visits.Your ability to function in daily life is severely limited, with a score of 45 or less on a specific assessment.I have been on the same mental health medication for at least 6 weeks.I am between 22 and 70 years old.You have a Global Assessment of Function (GAF) score of 45 or lower, which means you have difficulty functioning in your daily life.
- Group 1: Deep Brain Stimulation
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is it possible to become a participant in this experiment?
"This clinical trial seeks to enrol sixteen individuals aged between 22 and 70 who are suffering from depression. To be eligible, participants must possess a 24-item Hamilton Depression Rating Scale score of 21 or higher on the first 17 items, Global Assessment of Function rating at 45 or lower, recurrent (4 episodes+) or chronic (>2 years) course with minimum 5 years since initial episode onset as well as major impairment in functioning/potential severe medical outcomes. Furthermore, they must have attempted 6+ weeks of antidepressant treatment across three classes before entry into study alongside 4+weeks augmentation/combination using lithium, T3 etc., unsuccessful ECT"
Is this research looking for participants of a certain age range?
"As per the requirements stipulated for inclusion in this medical trial, participants must be between 22 and 70 years old."
Could you tell me if this study is actively enrolling participants?
"The information on clinicaltrials.gov indicates that this medical trial is no longer enrolling patients, with the original posting dating back to November 1st 2013 and the last update occurring on September 6th 2022. Nonetheless, there are still 1305 other studies actively recruiting volunteers at present."
Who else is applying?
What state do they live in?
How old are they?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Why did patients apply to this trial?
How responsive is this trial?
Typically responds via
Most responsive sites:
- UT Center of Excellence on Mood Disorders: < 48 hours
Average response time
- < 2 Days
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