AI Assisted Personalized Legacy Program for Serious Illness

Recruiting at 1 trial location

Overseen By Melissa Felt

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Mayo Clinic

Disqualifiers: Schizophrenia, Bipolar, Suicide attempt, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

40 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a new program that uses artificial intelligence to help people with serious illnesses leave a personal legacy. Researchers aim to determine if they can successfully recruit participants and deliver this program to those in need. The trial specifically seeks adults with health conditions that carry a high risk of death. Participants must be able to communicate in English and complete questionnaires, either independently or with assistance. Those with untreated serious mental health conditions or who are already involved in similar programs are not eligible.

As an unphased trial, this study offers participants a unique opportunity to contribute to innovative research that could benefit others in similar situations.

Do I need to stop my current medications to join the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that the AI Assisted Personalized Legacy Program is safe for patients with serious illness?

Research has shown that the AI Assisted Personalized Legacy Program is a low-risk option, meaning it carries fewer risks than other treatments. Studies at the Mayo Clinic examined its practicality and effectiveness, suggesting that patients with serious illnesses tolerate it well.

The program adheres to strict regulations for protecting health data in both the EU and USA, ensuring participant safety. Although specific information on negative side effects is not available, being labeled as low-risk indicates that participants have not encountered major safety issues so far.

Overall, the available evidence suggests the program is safe for use. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the AI Assisted Personalized Legacy Program because it offers a new approach to support individuals with serious illnesses. Unlike traditional treatments that focus on medical interventions, this program uses artificial intelligence to create personalized legacy projects, helping patients and their families capture meaningful memories and narratives. This approach aims to improve emotional well-being and provide a sense of closure, addressing the psychological and emotional aspects of serious illness that standard medical treatments often overlook. By integrating technology with personal storytelling, this program has the potential to enhance the quality of life for patients and their loved ones during challenging times.

What evidence suggests that the AI Assisted Personalized Legacy Program is effective for serious illness?

Research has shown that the AI Assisted Personalized Legacy Program, provided to participants in this trial, eases emotional and existential distress in patients with serious illnesses. This program uses AI to create personalized "legacy" documents, reflecting a patient’s life and experiences. The process is quick and tailored to each individual, offering emotional comfort. Studies have found this support suitable for people from various cultural backgrounds. While the primary focus is on creating meaningful documents, the ultimate goal is to provide emotional relief and a sense of peace to those facing serious health challenges. ^{1 2 6 7 8}

Who Is on the Research Team?

Deirdre Pachman, MD

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for patients experiencing deep emotional distress due to a serious illness. It aims to see if it's possible and acceptable to offer them an AI Assisted Personalized Legacy Program.

Inclusion Criteria

I am 18 years old or older.

English fluency

Provide informed consent

Exclusion Criteria

My condition is advanced dementia.

Participation in concurrent legacy offerings through the palliative care clinic

Recent suicide attempt or psychiatric illness severe enough that hospitalization has been necessary in last 6 months

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants engage in the AI Assisted Personalized Legacy Program, which involves individualized psychotherapy sessions to relieve psycho-emotional and existential distress.

5-10 days

Sessions with a trained facilitator

Follow-up

Participants are monitored for acceptability and feasibility of the intervention, with assessments conducted 5-10 days post-delivery of the final legacy document.

5-10 days

What Are the Treatments Tested in This Trial?

Interventions

• AI Assisted Personalized Legacy Program

Trial Overview The study is testing the use of an AI Assisted Personalized Legacy Program designed to help patients with serious illnesses by providing emotional support and helping them reflect on their life stories.

How Is the Trial Designed?

Group I: AI Assisted Personalized Legacy Program Experimental Treatment 1 Intervention

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials

3,427

Recruited

3,221,000+

Citations

1. jpsmjournal.com jpsmjournal.com/article/S0885-3924(25)00384-7/fulltext

Culturally Appropriate AI-Assisted Personalized Legacy ... This AI tool can be used to assist in creation of legacy documents for patients from a variety of racial and ethnic backgrounds to assess biases.

2. clinicaltrials.gov clinicaltrials.gov/study/NCT07009210?term=AREA%5BConditionSearch%5D(Seriousness)&rank=5

AI Assisted Personalized Legacy Program (Reflections: My ... The purpose of this study is to determine if it is feasible and acceptable to recruit for and deliver the AI Assisted Personalized Legacy Program intervention ...

3. mayo.edu mayo.edu/research/clinical-trials/cls-20586743

AI Assisted Personalized Legacy Program for Palliative ... The AI Assisted Personalized Legacy Program intervention is a brief, individualized psychotherapy that aims to relieve psycho-emotional and existential distress ...

4. sciencedirect.com sciencedirect.com/science/article/abs/pii/S0885392425003847

Culturally Appropriate AI-Assisted Personalized Legacy ... This AI tool can be used to assist in creation of legacy documents for patients from a variety of racial and ethnic backgrounds to assess biases.

5. patlynk.com patlynk.com/trial/NCT07009210

AI Assisted Legacy Program for Serious Illness Patients The program uses artificial intelligence to help create a "legacy" document, which is a personal reflection of the patient's life. The goal is to help ease ...

6. computer.org computer.org/publications/tech-news/trends/make-legacy-databases-ai-ready

How to Make Legacy Databases AI-Ready Typical components to create an AI-ready database include scalable storage, high throughput ingestion, support for diverse data types, in- ...

7. verdantix.com verdantix.com/client-portal/blog/the-future-of-ehs-lies-in-ai-that-acts--not-just-assists

The Future Of EHS Lies In AI That Acts, Not Just Assists The Verdantix Future Of AI-Enabled EHS Software Solutions report highlights how AI capabilities are evolving from assistive to autonomous, and ...

8. emerj.com emerj.com/transforming-shutdown-turnaround-and-hse-operations-in-energy-spaces-with-ai-with-leaders-from-oxy-nov-and-altaml/

Transforming Shutdown, Turnaround, and HSE Operations ... AI can connect to these legacy safety systems and regulatory databases to generate a briefing in seconds, turning what used to be a laborious ...