CPAP + Lifestyle Intervention for Prediabetes
(TECH Trial)
Trial Summary
What is the purpose of this trial?
Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular complications in this high-risk population. Sleep apnea is a highly common condition in prediabetes, but it has been mostly ignored and undertreated in current practice. The proposed study will be the first to assess whether adding CPAP (continuous positive air pressure) treatment to a lifestyle intervention improves cardiometabolic outcomes beyond that achieved with lifestyle alone (i.e. current standard of care) in high-risk individuals with prediabetes.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of CPAP + Lifestyle Intervention for Prediabetes?
Is CPAP + Lifestyle Intervention safe for humans?
Lifestyle interventions, including diet and exercise, are generally safe and recommended for people at risk of type 2 diabetes. They have been shown to improve health outcomes without significant safety concerns. However, specific safety data for CPAP (Continuous Positive Airway Pressure) in combination with lifestyle interventions for prediabetes is not detailed in the provided research.23678
How does the CPAP + Lifestyle Intervention treatment for prediabetes differ from other treatments?
The CPAP + Lifestyle Intervention treatment is unique because it combines continuous positive airway pressure (CPAP) therapy, which is typically used for sleep apnea, with lifestyle changes like diet and exercise coaching. This approach not only targets blood sugar levels but also addresses sleep quality, which can indirectly improve eating habits and overall health outcomes.23459
Research Team
Esra Tasali, MD
Principal Investigator
University of Chicago
Eligibility Criteria
This trial is for overweight or obese individuals who have prediabetes and sleep apnea. It's not open to those with diabetes, currently in a weight loss program, or with diseases that could shorten life or make the treatments risky.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to either lifestyle intervention alone or lifestyle plus CPAP intervention for 6 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- CPAP Treatment
- Diet and exercise coaching
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Chicago
Lead Sponsor
Northwestern University
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator