Neuropathic Pain Clinical Trials 2022

Browse 81 Neuropathic Pain Medical Studies Across 163 Cities

9 Phase 3 Trial · 292 Neuropathic Pain Clinics

Clinical TrialsNeuropathic Pain Clinical Trials 2022
Reviewed by Michael Gill, B. Sc.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Transcranial Magnetic Stimulationfor Chronic Pain

New York, NY
18+
All Sexes
Around 80% of people with spinal cord injury (SCI) develop chronic neuropathic pain (CNP). This is a debilitating condition with major negative impacts on people's quality of life. Many treatment options have been offered (invasive stimulation, drugs) but provide limited effects and many secondary effects. There is a critical need to develop a new generation of therapies. Transcranial magnetic stimulation (TMS) is a non-invasive and painless brain stimulation technique that allows researchers to explore and change brain excitability that has shown promising effects in neuropathic pain. However there is not enough evidence of what are the long lasting effects of the different protocols. In this study, 30 SCI subjects with CNP in their hands will participate in the study. The objective is to evaluate the efficacy of real versus sham repetitive transcranial magnetic stimulation (rTMS) and investigate 1) short and long term effects on pain and 2) the behavioral and neurophysiological qualities of responders and non-responders to this treatment.This will be a randomized sham controlled trial with two groups: real or sham high frequency repetitive TMS protocol (20Hz). The protocol will be done daily for two weeks. Clinical, functional and neurophysiological evaluations will be assessed at baseline, post intervention and at 6-week follow up.
Recruiting
Device
25 Neuropathic Pain Clinical Trials Near Me
Spokane, WA
Corpus Christi, TX
Washington, United States
Greenwood Village, CO
More Trial Locations
An interactive map to display trial locations for Northwest Pain Care, Institute of Precision Pain Medicine, International Spine, Pain and Performance Center, Denver Back Pain Specialists, and 70 more locations.
Most Popular References for Neuropathic Pain Clinical Trials
Frequency
Citation
109
Zigmond, A. S., and R. P. Snaith. 1983. “The Hospital Anxiety and Depression Scale”. Acta Psychiatrica Scandinavica. Wiley. doi:10.1111/j.1600-0447.1983.tb09716.x.
67
Faul, Franz, Edgar Erdfelder, Albert-Georg Lang, and Axel Buchner. 2007. “G*power 3: A Flexible Statistical Power Analysis Program for the Social, Behavioral, and Biomedical Sciences”. Behavior Research Methods. Springer Science and Business Media LLC. doi:10.3758/bf03193146.
29
Farrar, John T., James P. Young, Linda LaMoreaux, John L. Werth, and Michael R. Poole. 2001. “Clinical Importance of Changes in Chronic Pain Intensity Measured on an 11-point Numerical Pain Rating Scale”. Pain. Ovid Technologies (Wolters Kluwer Health). doi:10.1016/s0304-3959(01)00349-9.
25
O'Connell NE, Ferraro MC, Gibson W, Rice AS, Vase L, Coyle D, Eccleston C. Implanted spinal neuromodulation interventions for chronic pain in adults. Cochrane Database Syst Rev. 2021 Dec 2;12:CD013756. doi: 10.1002/14651858.CD013756.pub2. Review.
19
Headache Classification Committee of the International Headache Society (IHS). 2013. “The International Classification of Headache Disorders, 3rd Edition (beta Version)”. Cephalalgia. SAGE Publications. doi:10.1177/0333102413485658.
19
Dworkin, Robert H., Dennis C. Turk, John T. Farrar, Jennifer A. Haythornthwaite, Mark P. Jensen, Nathaniel P. Katz, Robert D. Kerns, et al.. 2005. “Core Outcome Measures for Chronic Pain Clinical Trials: IMMPACT Recommendations”. Pain. Ovid Technologies (Wolters Kluwer Health). doi:10.1016/j.pain.2004.09.012.
18
“Headache Classification Committee of the International Headache Society (IHS) the International Classification of Headache Disorders, 3rd Edition”. 2018. “Headache Classification Committee of the International Headache Society (IHS) the International Classification of Headache Disorders, 3rd Edition”. Cephalalgia. SAGE Publications. doi:10.1177/0333102417738202.
18
Ljungqvist, Olle, Michael Scott, and Kenneth C. Fearon. 2017. “Enhanced Recovery After Surgery”. JAMA Surgery. American Medical Association (AMA). doi:10.1001/jamasurg.2016.4952.
15
Lefaucheur, Jean-Pascal, Andrea Antal, Samar S. Ayache, David H. Benninger, Jérôme Brunelin, Filippo Cogiamanian, Maria Cotelli, et al.. 2017. “Evidence-based Guidelines on the Therapeutic Use of Transcranial Direct Current Stimulation (tdcs)”. Clinical Neurophysiology. Elsevier BV. doi:10.1016/j.clinph.2016.10.087.
12
Rolke, R., R. Baron, C. Maier, T. R. Tölle, - D. R. Treede, A. Beyer, A. Binder, et al.. 2006. “Quantitative Sensory Testing in the German Research Network on Neuropathic Pain (DFNS): Standardized Protocol and Reference Values”. Pain. Ovid Technologies (Wolters Kluwer Health). doi:10.1016/j.pain.2006.01.041.
Top Hospitals for Neuropathic Pain Clinical Trials
Location
Active Neuropathic Pain Clinical Trials
All Time Trials for Neuropathic Pain
First Recorded Neuropathic Pain Trial
Trials
Stanford University, Stanford, California
4
6
2016
Exparel (Bupivacaine Liposome) for Migraine
, BHV3000 for Trigeminal Neuralgia
, [18F]FTC-146 for Chronic Pain ... View More
Virginia Commonwealth University, Richmond, Virginia
3
5
2014
Nicotine Transdermal Patch for Peripheral Neuropathy
, Virtual reality (VR) game 1 for Spinal Cord Injuries
, Ergocalciferol Capsules for Neuralgia
University of Michigan, Ann Arbor, Michigan
2
2
2011
MBSR treatment for Chronic Pain
, Spinal cord stimulation for Failed Back Surgery Syndrome
Neuroscience Research Center, LLC, Overland Park, Kansas
2
2
2018
Qutenza (capsaicin) 8% topical system for Post Surgical Neuropathic Pain
, Group 1 (Treatment) for Amputations
Boston Clinical Trials, Boston, Massachusetts
2
7
2011
Qutenza (capsaicin) 8% topical system for Post Surgical Neuropathic Pain
, LY3526318 for Neuralgia
Top Treatments for Neuropathic Pain Clinical Trials
Treatment Name
Active Neuropathic Pain Clinical Trials
All Time Trials for Neuropathic Pain
First Recorded Neuropathic Pain Trial
Trials
Active DBS
2
2
2017
Active DBS for Chronic Pain
, Active DBS for Complex Regional Pain Syndromes
Spinal Cord Stimulation
2
5
2014
Spinal Cord Stimulation for Pain, Intractable
, Spinal Cord Stimulation for Chronic Pain
[18F]FTC-146
2
2
2018
[18F]FTC-146 for Chronic Pain
, [18F]FTC-146 for Tissue Pain
PNS Therapy plus Conventional Medical Management
1
1
2022
PNS Therapy plus Conventional Medical Management for Chronic Pain
Transcranial Magnetic Stimulation
1
2
2016
Transcranial Magnetic Stimulation for Chronic Pain
Top Cities for Neuropathic Pain Clinical Trials
City
Active Neuropathic Pain Clinical Trials
Top Active Site for Neuropathic Pain Clinical Trials
Trial List
Boston, Massachusetts
10
Boston Clinical Trials
Qutenza (capsaicin) 8% topical system for Post Surgical Neuropathic Pain
, Gabapentin for Neuralgia
, Basimglurant for Trigeminal Neuralgia ... View More
Chicago, Illinois
9
Northwestern University
Qutenza (capsaicin) 8% topical system for Post Surgical Neuropathic Pain
, Qutenza (capsaicin) 8% topical system for Post Surgical Neuropathic Pain
, Basimglurant for Trigeminal Neuralgia ... View More
Miami, Florida
9
University of Miami
BHV3000 for Trigeminal Neuralgia
, LY3526318 for Neuralgia
, LY3526318 for Neuralgia ... View More
Baltimore, Maryland
8
Johns Hopkins University
BHV3000 for Trigeminal Neuralgia
, Experimental: ExAblate Transcranial treatment for Spinal Cord Injuries
, Erenumab-aooe for Trigeminal Neuropathy ... View More
San Antonio, Texas
6
South Texas Health Care System, San Antonio, TX
CBD (Epidolex) for Diabetic Neuralgia
, LY3526318 for Neuralgia
, SLC022 for Postherpetic Neuralgia ... View More
Which phases are most popular for neuropathic pain clinical trials?
Phase
Active Neuropathic Pain Clinical Trials
Number of Unique Treatments
Number of Active Locations
Trial List
Phase < 1
1
1
1
Coordinated Reset spinal cord stimulation for Failed Back Surgery Syndrome
Phase 1
5
4
2
Autologous Platelet Rich Plasma Injection for Headache
, GTX-101 for Postherpetic Neuralgia
, BAY2395840 for Diabetic Neuralgia ... View More
Phase 1 & 2
4
4
5
Ondansetron 16 mg with Tariquidar for Neuralgia
, Brivaracetam for Spinal Cord Injuries
, KLS-2031 for Radiculitis ... View More
Phase 2
19
19
86
Exparel (Bupivacaine Liposome) for Migraine
, Nicotine Transdermal Patch for Peripheral Neuropathy
, BHV3000 for Trigeminal Neuralgia ... View More
Phase 2 & 3
1
1
7
Basimglurant for Trigeminal Neuralgia
Phase 3
8
8
39
300 mg Gabapentin 3X per day for Thoracotomy
, Qutenza (capsaicin) 8% topical system for Post Surgical Neuropathic Pain
, Lidocaine topical for Sphenopalatine Neuralgia ... View More
Phase 4
4
4
3
Venlafaxine 37.5 MG for Acute Pain
, Ketamine Infustion for Brachial Plexus Injury
, Galcanezumab for Trigeminal Neuralgia ... View More
N/A
39
37
85
PNS Therapy plus Conventional Medical Management for Chronic Pain
, Transcranial Magnetic Stimulation for Chronic Pain
, MBSR treatment for Chronic Pain ... View More
How many neuropathic pain clinical trials are open to youth and / or seniors?
Age Group
Active Neuropathic Pain Clinical Trials
Trial List
18+
72
PNS Therapy plus Conventional Medical Management for Chronic Pain
, Transcranial Magnetic Stimulation for Chronic Pain
, 300 mg Gabapentin 3X per day for Thoracotomy ... View More
18 - 65
4
Functional Electrical Stimulation rowing exercise for Spinal Cord Injuries
, GTX-101 for Postherpetic Neuralgia
, Mindfulness Based Intervention for Pain, Intractable ... View More
< 65
4
Lidocaine topical for Sphenopalatine Neuralgia
, Pregabalin for Pruritus
, Gabapentin for Neuralgia ... View More
Any Age
1
Internal environment for Hepatitis
Most Recent Neuropathic Pain Clinical Trials
Clinical Trial
Began Recruiting Date
Phase
Ergocalciferol Capsules for Neuralgia
9/30/2022
Phase 2
Transcranial Magnetic Stimulation for Chronic Pain
9/1/2022
N/A
Auricular acupuncture for Neuralgia
9/1/2022
N/A
Exparel (Bupivacaine Liposome) for Migraine
8/1/2022
Phase 2
GTX-101 for Postherpetic Neuralgia
7/26/2022
Phase 1
Phase 3 Neuropathic Pain Clinical Trials
Clinical Trial
Began Recruiting Date
Phase
Basimglurant for Trigeminal Neuralgia
1/11/2022
Phase 2 & 3
Qutenza (capsaicin) 8% topical system for Post Surgical Neuropathic Pain
7/13/2021
Phase 3
Electroacupuncture for Neuralgia
5/21/2021
Phase 3
300 mg Gabapentin 3X per day for Thoracotomy
4/6/2021
Phase 3
Pregabalin for Pruritus
8/7/2019
Phase 3
Pediatric Neuropathic Pain Clinical Trials
Clinical Trial
Began Recruiting Date
Phase
Internal environment for Hepatitis
3/1/2021
Phase 1 & 2
[18F]FTC-146 for Chronic Pain
11/19/2020
Phase 1
Pregabalin for Pruritus
8/7/2019
Phase 3
Lidocaine topical for Sphenopalatine Neuralgia
6/6/2019
Phase 3
Senior Friendly Neuropathic Pain Clinical Trials
Clinical Trial
Began Recruiting Date
Phase
Ergocalciferol Capsules for Neuralgia
9/30/2022
Phase 2
Transcranial Magnetic Stimulation for Chronic Pain
9/1/2022
N/A
Auricular acupuncture for Neuralgia
9/1/2022
N/A
Exparel (Bupivacaine Liposome) for Migraine
8/1/2022
Phase 2
Tetrodotoxin for injection for Chemotherapy-induced Peripheral Neuropathy
4/19/2022
Phase 2
Recently Completed Studies with FDA Approved Treatments for Neuropathic Pain
Treatment
Year
Mechanism of Action
Sponsor
Active Neuropathic Pain Clinical Trials
ETX-018810
2020
Eliem Therapeutics (UK) Ltd.
0
BAY1817080
2020
Bayer
0
LY3016859
2020
Eli Lilly and Company
0
LX9211 high dose
2020
Lexicon Pharmaceuticals
0
NYX-2925 50 mg
2019
Aptinyx
0

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 2nd, 2021

Last Reviewed: August 17th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

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