Treatment for Lymphoma

Waitlist Available · 18+ · All Sexes · Yelm, WA

This study is evaluating whether chemotherapy and stem cell transplant is better than chemotherapy alone for people with primary CNS B-cell lymphoma.

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About the trial for Lymphoma

Treatment Groups

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.


This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Previous Treatment: Patients must not have had chemotherapy or radiation therapy for lymphoma in the past. show original
The patient must be aged between 18 and 75 years old. show original
Patients must not have any evidence or history of non-Hodgkin lymphoma (NHL) outside of the central nervous system (CNS, brain and spinal cord). show original
The patient must not have any history of organ transplants or be currently taking immunosuppressant drugs. show original
Pregnancy and Nursing Status - Patients must be non-pregnant and non-nursing; women of childbearing potential must have a negative serum or urine pregnancy test 10-14 days prior to registration; in addition, women and men of childbearing potential must commit to use an effective form of contraception throughout their participation in this study; appropriate methods of birth control include abstinence, oral contraceptives, implantable hormonal contraceptives, or double barrier method (diaphragm plus condom)
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Odds of Eligibility
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Up to 10 years
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Up to 10 years.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Treatment will improve 1 primary outcome and 3 secondary outcomes in patients with Lymphoma. Measurement will happen over the course of Up to 10 years.

progression free survival
overall survival
number of participants with treatment-related adverse events as assessed by CTCAE v4.0
event free survival

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes lymphoma?

In most cases it is not clear why lymphoma develops, and the exact causes remain unproven. It is likely that there are many different factors involved, and that each of these can contribute to a developing disease. Lymphoma may be caused by viruses or viruses may cause lymphoma by triggering mutations in normal cells. Most lymphomas are probably multifactorial. However, several agents are known or suspected of being causes, including cancer-causing bacteria such as "Mycobacterium avium" complex (MAC) and Epstein-Barr virus, which have a role in development and progression of some lymphomas. Some lymphomas are due to genetic syndromes.

Anonymous Patient Answer

Can lymphoma be cured?

We conclude that in a selected group of patients with non-Hodgkin's lymphoma, chemotherapy can induce very durable complete remissions. This approach to cure lymphoma still requires prospective trials and large prospective registries.

Anonymous Patient Answer

What is lymphoma?

Lymphoma is a cancer that starts in white blood cells (lymphocytes) and can form anywhere in the body. Patients frequently have a history of exposure to a common virus in childhood, and then develop a lymphoma five to 20 years later. The most common form is non-Hodgkin Lymphoma, which consists of a wide range of types of lymphoma, including T-cells and M-cells. Lymphoma has also been called "glandular lymphoma".\n

Anonymous Patient Answer

How many people get lymphoma a year in the United States?

Approximately one out of every 3,000 US adults will develop lymphoid cancer, making lymphoma the ninth-most common type of cancer diagnosed annually in the US.

Anonymous Patient Answer

What are the signs of lymphoma?

Lymphoma patients will present with cough, night sweats, and anorexia. Rarely, tumour can be identified as an enlarged lymph node. For patients with no obvious signs or symptoms of lymphoma, further investigations are not necessary.

Anonymous Patient Answer

What are common treatments for lymphoma?

Although many patients with lymphoma will respond to one or more of the treatment options described below, there is considerable variation in outcomes, response, and tolerability of treatment. Patients with less aggressive lymphoma may have long-term survival after treatment. Lymphoma is still a devastating disease, and innovative, experimental therapies (e.g., immunotherapy) are being pursued in an effort to find more effective ways to treat lymphoma.

Anonymous Patient Answer

Does treatment improve quality of life for those with lymphoma?

Data from a recent study corroborate those of two similar previous studies on the general population. No statistical differences were noted for physical QOL or psychological QOL improvements in all 3 studies. Data from a recent study strongly support the need for treatment to improve physical functioning and psychological well-being for people with lymphoma.

Anonymous Patient Answer

What are the latest developments in treatment for therapeutic use?

In spite of the availability of highly effective therapies, there are still significant treatment-related problems, including those related to the development of drug-resistance, toxicity and patient-specific issues. These continue to present a challenge for the evolving treatment of cancer. New discoveries may lead to the discovery of improved and simplified treatment regimens for cancer patients in the future.

Anonymous Patient Answer

Have there been any new discoveries for treating lymphoma?

“There is no evidence that a single type of treatment is more helpful against the other types of lymphoma and their subtypes.” “The chemotherapy and the radiotherapy do not kill the cancer in the same way and they have been found to work better as an alternate or in combination.” “If the treatment for one form of the cancer is a drug, and the drug has been found not to work against the other cancer, then it is not in the best interest of the person if she is taken off the other therapy.” “Sometimes the cancer stays where it is and is not put under treatment until after a very short period of time.

Anonymous Patient Answer

How serious can lymphoma be?

This is quite often the case. The average age of time from diagnosis is 5 years but ranges from 3 to 12 years. Even though most of the time there is a good prognosis lymphoma is a very difficult to treat and can become very bad. But they can be cured or at least not get worse. Lymphoma treatment is usually made of chemotherapy or surgical manipulation plus radiotherapy, the goal being that the cancer is removed from your body and stays there. This way when you get diagnosed with the cancer you are already

Anonymous Patient Answer

What are the common side effects of treatment?

Patients treated with radiation for any cause can experience an increase in temporary side effects such as skin rashes. A decrease in their immune system’s ability to fight cancer can result from the use of steroids. The drugs do not always have a lot of side effects for long-term use.\n\n- Oncolytic virus therapy"

"Oxytenius parvus\n\nOxytenius parvus, commonly called the black-and-yellow cave crab or the tiny cave crab, is a species of crab which is endemic to southwestern China where it inhabits caves in Qinghai, Sichuan and Tibet.

Anonymous Patient Answer

What is the average age someone gets lymphoma?

One year the majority of lymphomas develop in adulthood. The overall median age of development is about 52 years; the male:female incidence ratio is 1.6:1 and about 30% of the lymphomas occurred in the early twenties. The most common types of lymphoma occurring in adulthood are diffuse large B-cell lymphoma, mantle cell lymphoma, small cell lymphoma and splenic marginal zone lymphoma. The incidence of these is in contrast to childhood. In the early twentieth century Hodgkins disease was a childhood disease occurring mainly in children under 15 years of age. Recently the incidence rate of childhood non-Hodgkins lymphoma has been increasing with more teenagers afflicted with this disease.

Anonymous Patient Answer
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