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Chemotherapy + Stem Cell Transplant for Lymphoma
Study Summary
This trial will compare two types of chemotherapy to see which is more effective in treating primary CNS B-cell lymphoma.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am mostly independent but may need assistance for some daily activities.My diagnosis of brain lymphoma was confirmed through a biopsy or fluid tests.I have not had chemotherapy or radiation for lymphoma.I am between 18 and 75 years old.I do not have hepatitis C, and if I had hepatitis B, it's under control or being monitored.I am not pregnant or nursing and will use effective birth control during the study.My lymphoma is only in my brain or spinal cord, not elsewhere.I have never had an organ transplant or been on ongoing immunosuppressant therapy.
- Group 1: Arm II
- Group 2: Arm I
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 10 Other Conditions - This treatment demonstrated efficacy for 10 other conditions.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What medical issues is this remedy typically utilized for?
"Acute lymphoblastic leukemia (ALL) can often be treated with this pharmaceutical intervention. Additionally, glioblastoma, brain stem gliomas and non-Hodgkin's Lymphoma are all ailments that may benefit from the same treatment."
What is the cap on enrollment for this experiment?
"This particular clinical trial has concluded its recruitment phase. Initially posted on September 1st 2012, the last update was made August 16th 2021. Nevertheless, there are still 1717 medical trials accepting lymphoma patients and 612 studies recruiting for this medication that remain open to new participants."
Are there any openings for participation in this experiment?
"Sadly, no more participants are being accepted for this trial. It was first posted on September 1st 2012 and the latest update occured on August 16th 2021. If you're seeking out other trials relating to lymphoma, there currently exist 1717 open studies with 612 recruiting patients for that intervention."
Is enrollment for this research project still open?
"An enrolment of 113 participants has been approved for this medical trial, all aged between 18 and 75. To qualify, patients must have no prior chemotherapy or radiation therapy for lymphoma as well as a confirmed diagnosis from either brain biopsy/resection or cerebrospinal fluid/vitreous fluid; be negative for HIV serology and HCV serology (unless HBsAb positive patient has recently received HBV vaccine); measure Karnofsky Performance Scale ≥ 30 (≥ 50 for those ages 60-70) and possess an ANC ≥ 1500/mcL with AST & ALT < 2 x upper limit of normal"
Does this study accept applicants aged 70 and above?
"As per the listed inclusion criteria, this study is suitable for individuals between ages 18 and 75. There are 536 clinical trials geared towards minors under 18 years old and 1960 studies that cater to elderly adults over 65."
Has there been any past research conducted on this particular remedy?
"In 1997, City of Hope Comprehensive Cancer Center initiated the first clinical trial with this particular medication. Since then, 1138 studies have been completed while 612 are still ongoing - notably, a significant number are being conducted in Walla Walla, Washington."
Is there a multiple-site deployment of this study in Canada?
"The present medical trial is operating out of an extensive network of 100 sites; these include the cities Walla Walla, Franklin and Kettering. To reduce any potential travel burden, it is advised that participants choose their nearest clinical centre."
Has this remedial protocol been sanctioned by the FDA?
"Despite the lack of clinical evidence that this treatment is effective, there are some safety data points available. Consequently, our team at Power assigned a rating of 2 to its safety profile."
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