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2X-121 for Ovarian Cancer (PREDICT 2X-121 Trial)
PREDICT 2X-121 Trial Summary
This trial will test the effectiveness of 2X-121, given as a pill once daily, as a treatment for ovarian cancer in patients predicted to respond well to the drug.
PREDICT 2X-121 Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowPREDICT 2X-121 Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.PREDICT 2X-121 Trial Design
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Who is running the clinical trial?
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- You have HIV.You have a medical condition that can be seen on a CT scan or MRI.I have not had a serious heart condition or stroke in the last 6 months.I have tumor tissue samples available from surgery.You are expected to live for more than 16 weeks.Your blood test results for neutrophils, hemoglobin, platelets, liver enzymes, bilirubin, alkaline phosphatase, creatinine, and blood urea should be normal.I have active hepatitis B or C.Women who could become pregnant must have a negative pregnancy test.I have recovered from any major side effects of my previous cancer treatments.I can take pills and do not have ongoing stomach or bowel problems.I am not currently receiving chemotherapy, radiotherapy, or hormonal therapy for my condition.I am 18 years old or older.My ovarian cancer has been treated with 2 or more chemotherapies, including possibly PARP inhibitors.I have had cancer before, but it was early stage and considered cured.I am currently on antibiotics for an infection.My latest tumor test shows I'm likely to respond well to treatment.It has been 3 months or more since my last platinum-based chemotherapy.I can carry out all my self-care but cannot do heavy physical work.I need urgent care to relieve my symptoms, possibly including surgery or radiation.
- Group 1: 2X-121
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any open positions for this clinical trial?
"This study, which was originally posted on April 15th 2019, is currently looking for patients. The last update to the listing was on October 7th 2022."
Are there any risks associated with the use of 2X-121?
"2X-121 falls into the Phase 2 category, meaning that while there is data supporting its safety, there is none yet attesting to its efficacy. Our team at Power gave it a score of 2."
How many patients are trialing this medication?
"Yes, this research is currently recruiting patients as the website clinicaltrials.gov indicates. The trial was established on April 15th, 2019 and was updated October 7th, 2020. 1 site is looking for a total of 60 individuals to participate."
Have similar experiments been conducted before?
"To date, there is a single active clinical trial for 2X-121 being conducted in two metropolises and across two sovereign states. The first study of its kind was completed in 2019 by Allarity Therapeutics. This particular research project involved 60 test subjects and successfully completed Phase 2 drug approval. As of now, 1 additional trial has been carried out."
What is the current understanding of 2X-121's efficacy?
"At the moment, 1 clinical trial is underway for 2X-121. 0 of those trials are in their third and final phase. Most of the research for 2X-121 is conducted in Glasgow, but studies are also taking place in Oklahoma at 4 different locations."
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