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Metformin + Digoxin + Simvastatin for Pancreatic Cancer
Study Summary
This trial is for people with pancreatic cancer and other advanced solid tumors. It's an open-label, single arm dose escalation Phase IB trial, which means that subjects are accrued in a 3 subject dose escalation cohort.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2015 Phase 3 trial • 33 Patients • NCT02030041Trial Design
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Who is running the clinical trial?
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- My blood tests show normal organ function and healthy blood cell counts.I am pregnant or nursing.I have a heart condition like Wolff-Parkinson-White Syndrome or a history of serious heart issues.I have recovered from side effects of previous treatments, except for some nerve issues.I had another cancer but was treated successfully over 3 years ago, except for certain skin, bladder, or in situ cancers.Patients whose disease does not show up on a PET scan will be excluded.I can take care of myself but might not be able to do active work.I am 18 or older with a confirmed solid tumor diagnosis.I have HIV or chronic Hepatitis B or C.You have had serious allergic reactions to Metformin, Simvastatin, or Digoxin in the past.I have a tumor that can be biopsied with a needle.I haven't had a live vaccine within the last 30 days or an inactivated vaccine within the last 14 days.My condition hasn't improved with standard treatments.I have enough stored tissue samples for the study.My brain cancer was treated with surgery or gamma knife and hasn't worsened in 2 months.I am showing signs of an active infection.I have a history of rhabdomyolysis.I haven't had cancer treatment or radiation in the last 3 weeks.
- Group 1: Dose Escalation
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Frequently Asked Questions
Is this investigation accessible to patients at the moment?
"Affirmative. Evidence provided by clinicaltrials.gov attests to this medical trial's active recruitment status, which began on June 5th 2019 and was most recently revised in November 2021. Fifteen volunteers need to be sourced from one location for the study's completion."
What implications does taking Simvastatin have for people's physical health?
"The current clinical evidence base for Simvastatin's safety and efficacy is sparse, resulting in a score of 1."
What is the current patient participation rate of this clinical research?
"Affirmative. Data available on clinicaltrials.gov show that, after being first posted on June 5th 2019 and most recently updated November 16th 2021, this trial is currently in search of 15 participants at a single site."
What are the common applications of Simvastatin?
"Simvastatin is a viable option for treating cholesterol, polycystic ovary syndrome and diabetes that cannot be properly regulated through diet and exercise."
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