Skin Biopsy for Peripheral Nervous System Diseases
This study is evaluating whether ultrasound may be a better way to detect neuropathy in patients with gastrointestinal cancer.
See full descriptionAbout the trial for Peripheral Nervous System Diseases
Treatment Groups
This trial involves 2 different treatments. Skin Biopsy is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
About The Treatment
Eligibility
This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Skin Biopsy will improve 1 primary outcome and 9 secondary outcomes in patients with Peripheral Nervous System Diseases. Measurement will happen over the course of Up to 30 days.
Patient Q & A Section
What are common treatments for peripheral nervous system diseases?
This article outlines the pharmacological treatment of PNS diseases such as PNI, CIDP and CRPS. The medications used are as diverse as the patient group. Nerve block injections and botulinum toxin injections have been used in managing sensory neuropathic pain. Additionally, a number of adjuvants such as steroids (in most cases glucocorticoids), bisphosphonates, D-Penicillamine and azathioprine have been used successfully to manage pain. The role of anticonvulsants in management of chronic pain has been studied extensively but not as thoroughly as that observed in bipolar disorder. There is high rate of spontaneous or spontaneous in the case of PNS diseases.
How many people get peripheral nervous system diseases a year in the United States?
The most common PNS disease in children <17 years of age is headache. This data must be considered when assessing the burden of health care use in this group. The most common PNS disease in children ≥17 years old is idiopathic sudden sensorineural hearing loss.
What is peripheral nervous system diseases?
PNS diseases are conditions in which a specific dysfunction in the control and organization of the nervous system exists and determines, rather than is itself determined, by a set of common causes. PNS diseases usually affect one or more of the basic nerve-motor and sensory-receptive nerve-motor systems of the autonomic, somatic, or autonomic nervous, and sensory-receptive systems. PNS diseases include all medical and surgical disorders resulting in dysfunction and diseases that affect the autonomic, somatic, or sensory-receptive nervous systems.
What are the signs of peripheral nervous system diseases?
In cases of peripheral nervous system disease, it is necessary for the family and general practitioner to recognize these signs and arrange the appropriate examinations for the patient. Peripheral neuropathies may occur in all ages, from infancy to old age. However, most are first diagnosed in late adolescence, early adulthood, or in later years after the initial onset.
What causes peripheral nervous system diseases?
The causes of peripheral nervous system diseases are not well understood because many diseases are not obvious at the time of diagnosis. The main factors related to the onset or the worsening of a peripheral nervous system disease are a history of chronic exposure to a suspected neurotoxic agent, genetic predisposition, or metabolic disorders which have a known relationship with peripheral nervous system diseases. The onset or worsening of peripheral nervous system disease is often caused by a combination of these factors or other factors not explicitly referred to. Therefore, prevention of peripheral nervous system diseases may include strategies for decreasing the exposure to suspected neurotoxic agents, modifying the genetic predisposition for peripheral nervous system diseases, and managing metabolic disorders which relate to peripheral nervous system diseases.
Can peripheral nervous system diseases be cured?
Most disorders of neural function can be controlled to some degree and the outcomes are generally good. Therefore, these disorders should not be classified as hopeless diseases.
What is the survival rate for peripheral nervous system diseases?
There appears to be low survival rates for peripheral nervous system diseases. Future research should focus on improving survival rates for peripheral nervous system diseases so that they will not be a burden to society.
Is skin biopsy typically used in combination with any other treatments?
Skin biopsy is commonly used in combination with treatment for patients being investigated for a suspected tumour, but without any treatment being suggested in almost half of the cases. Since the diagnostic yield of biopsy is low, skin biopsy should be reserved for patients with a specific diagnostic or exclusion question or to help guide a definitive management.
How does skin biopsy work?
Skin biopsy is the gold standard for the diagnosis and grading of systemic sclerosis. It is important to emphasize that it is the definitive test for the diagnosis of all forms of dermatosclerosis and connective tissue diseases.
Is skin biopsy safe for people?
This retrospective review in an advanced referral hospital in Western Australia found that skin biopsy was frequently performed as an outpatient procedure. Although the risks are not insignificant, there were few reports of major complications and serious morbidities. The procedure is often well accepted by patients.
What is the primary cause of peripheral nervous system diseases?
This comprehensive review confirms that primary PNS diseases are associated with identifiable risk factors and is likely to be related to the interaction of multiple factors.
What is the average age someone gets peripheral nervous system diseases?
The average age of first onset of PNSWDI has not changed, and the average age of symptom onset has risen by 4+ years in recent years. In a recent study, findings suggest that the average age of onset of PNSWDI is now approximately 43 years of age.