140 Participants Needed

Tango for Neuropathy

(DAANCE Trial)

LW
Overseen ByLise Worthen-Chaudhari, PhD, MFA, CMES
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: Ohio State University Comprehensive Cancer Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

Trial Summary

What is the purpose of this trial?

Up to 80% of breast cancer survivors experience chemotherapy-induced neuropathy that impairs quality of life and increases fall risk long into survivorship, yet treatment options for neuropathy remain limited. The successful treatment will target neurophysiologic mechanisms for restoring function while addressing patient-reported symptoms and participation in treatment. Toward this end, the investigators propose to study a noninvasive, social sensorimotor intervention - Adapted Argentine Tango - which targets motor control restoration, symptom alleviation, and treatment participation in concert.

Research Team

LB

Lise B Worthen-Chaudhari, PhD, MFA, CMES

Principal Investigator

Ohio State University

MB

Maryam B Lustberg, MD, MPH

Principal Investigator

Yale University

Eligibility Criteria

This trial is for breast cancer survivors who finished taxane-based chemotherapy at least 3 months ago, are experiencing neuropathy symptoms, and have a risk of falling. They must be able to follow study instructions. People with vestibular dysfunction, severe diabetes, hearing loss, or unstable medical conditions that prevent physical activity cannot join.

Inclusion Criteria

My breast cancer is at any stage from I to IV, including if it has spread.
I am experiencing symptoms of nerve pain or damage from chemotherapy.
Able to understand and comply with directions associated with testing and study treatments
See 2 more

Exclusion Criteria

Pre-existing vestibular dysfunction
My doctor says I can't join in the exercise study due to another health issue.
I have severe hearing loss in both ears.
See 3 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Control

Participants receive 4 weeks of usual care followed by optional 1-way crossover to 8 weeks of partnered, adapted tango dance

4 weeks
1 visit (in-person)

Experimental

Participants receive 8 weeks of partnered, adapted tango dance

8 weeks
8 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

6 months
3 visits (in-person)

Treatment Details

Interventions

  • Adapted Argentine Tango
Trial Overview The DAANCE trial is testing Adapted Argentine Tango as a treatment for chemotherapy-induced neuropathy in breast cancer survivors. It aims to improve motor control and reduce symptoms while encouraging participation in the therapy.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: ExperimentalExperimental Treatment1 Intervention
8 weeks of intervention (partnered, adapted tango dance)
Group II: ControlActive Control1 Intervention
4 weeks of usual care followed by optional 1-way crossover to 8 weeks of Intervention (partnered, adapted tango dance)

Find a Clinic Near You

Who Is Running the Clinical Trial?

Ohio State University Comprehensive Cancer Center

Lead Sponsor

Trials
350
Recruited
295,000+

Emory University

Collaborator

Trials
1,735
Recruited
2,605,000+

National Institute on Aging (NIA)

Collaborator

Trials
1,841
Recruited
28,150,000+

Yale University

Collaborator

Trials
1,963
Recruited
3,046,000+
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