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Procedure

TMS Impact on Cognitive Sequencing

N/A
Recruiting
Led By John E Desmond, Ph.D.
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18-50
Be between 18 and 65 years old
Must not have
Neurological or systemic disorder which can cause dementia or cognitive dysfunction
History of definite stroke
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during scan up to 1 hour
Awards & highlights

Summary

This trial aims to explore how the cerebellum contributes to both motor and cognitive functions, by testing how disruption and stimulation of the cerebellum can affect the ability to predict and sequence events.

Who is the study for?
This trial is for individuals aged 18-50 who can consent, have at least an 8-year education, speak English fluently, and are right-handed. It's not for those with recent drug use, cognitive impairments due to neurological disorders, psychiatric disorders including substance abuse, stroke history, MRI contraindications or visual deficits.Check my eligibility
What is being tested?
The study tests the effect of cerebellar stimulation on brain activity during tasks that require sequencing and those that don't. Participants will undergo Transcranial Magnetic Stimulation (TMS) while performing these tasks to see how it affects their brain function.See study design
What are the potential side effects?
Potential side effects from TMS may include discomfort at the stimulation site, headache, lightheadedness or seizures in rare cases. Most people tolerate TMS well without serious complications.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 50 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have a condition that could lead to memory loss or trouble thinking.
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I have had a stroke before.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during scan up to 1 hour
This trial's timeline: 3 weeks for screening, Varies for treatment, and during scan up to 1 hour for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
functional magnetic resonance imaging brain activation
Secondary outcome measures
behavioral reaction time (milliseconds)
percent correct of behavioral responses

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Cerebellar StimulationExperimental Treatment4 Interventions
TMS will be administered to the cerebellum on half the trials of a sequence-demanding task, and on half the trials of a non-sequence-demanding task. Task order will be counterbalanced.
Group II: Occipital StimulationActive Control4 Interventions
TMS will be administered to an occipital control region on half the trials of a sequence-demanding task, and on half the trials of a non-sequence-demanding task. Task order will be counterbalanced.

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,820 Previous Clinical Trials
2,692,769 Total Patients Enrolled
Johns Hopkins UniversityLead Sponsor
2,285 Previous Clinical Trials
14,843,015 Total Patients Enrolled
John E Desmond, Ph.D.Principal InvestigatorJohns Hopkins University
1 Previous Clinical Trials
17 Total Patients Enrolled
~33 spots leftby Jul 2026
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