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TMS Impact on Cognitive Sequencing

Led By John E Desmond, Ph.D.
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18-50
Be between 18 and 65 years old
Screening 3 weeks
Treatment Varies
Follow Up during scan up to 1 hour
Awards & highlights

Study Summary

This trial aims to explore how the cerebellum contributes to both motor and cognitive functions, by testing how disruption and stimulation of the cerebellum can affect the ability to predict and sequence events.

Who is the study for?
This trial is for individuals aged 18-50 who can consent, have at least an 8-year education, speak English fluently, and are right-handed. It's not for those with recent drug use, cognitive impairments due to neurological disorders, psychiatric disorders including substance abuse, stroke history, MRI contraindications or visual deficits.Check my eligibility
What is being tested?
The study tests the effect of cerebellar stimulation on brain activity during tasks that require sequencing and those that don't. Participants will undergo Transcranial Magnetic Stimulation (TMS) while performing these tasks to see how it affects their brain function.See study design
What are the potential side effects?
Potential side effects from TMS may include discomfort at the stimulation site, headache, lightheadedness or seizures in rare cases. Most people tolerate TMS well without serious complications.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I am between 18 and 50 years old.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during scan up to 1 hour
This trial's timeline: 3 weeks for screening, Varies for treatment, and during scan up to 1 hour for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
functional magnetic resonance imaging brain activation
Secondary outcome measures
behavioral reaction time (milliseconds)
percent correct of behavioral responses

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Cerebellar StimulationExperimental Treatment4 Interventions
TMS will be administered to the cerebellum on half the trials of a sequence-demanding task, and on half the trials of a non-sequence-demanding task. Task order will be counterbalanced.
Group II: Occipital StimulationActive Control4 Interventions
TMS will be administered to an occipital control region on half the trials of a sequence-demanding task, and on half the trials of a non-sequence-demanding task. Task order will be counterbalanced.

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,784 Previous Clinical Trials
2,689,227 Total Patients Enrolled
Johns Hopkins UniversityLead Sponsor
2,260 Previous Clinical Trials
14,820,730 Total Patients Enrolled
John E Desmond, Ph.D.Principal InvestigatorJohns Hopkins University
1 Previous Clinical Trials
17 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research accepting geriatric participants?

"This research is seeking individuals aged 18 and up, yet no older than 50 years old."

Answered by AI

Is it possible for me to enroll in this clinical investigation?

"Enrolment in this experiment requires individuals aged 18-50 who demonstrate effects of cerebellar stimulation on brain activation. Approximately 50 volunteers are needed to participate in the trial."

Answered by AI

Are there any opportunities for new participants in this experiment?

"As reported on clinicaltrials.gov, this specific medical study is not in the process of recruiting patients at present. This trial had an initial posting date of February 1st 2024 and was most recently updated October 25th 2023. Nevertheless, there are currently one other trials that are actively enrolling volunteers for participation."

Answered by AI
~33 spots leftby Jul 2026