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Procedure

TMS Impact on Cognitive Sequencing

N/A

Recruiting

Led By John E Desmond, Ph.D.

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18-50

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during scan up to 1 hour

Awards & highlights

Study Summary

This trial aims to explore how the cerebellum contributes to both motor and cognitive functions, by testing how disruption and stimulation of the cerebellum can affect the ability to predict and sequence events.

Who is the study for?

This trial is for individuals aged 18-50 who can consent, have at least an 8-year education, speak English fluently, and are right-handed. It's not for those with recent drug use, cognitive impairments due to neurological disorders, psychiatric disorders including substance abuse, stroke history, MRI contraindications or visual deficits.Check my eligibility

What is being tested?

The study tests the effect of cerebellar stimulation on brain activity during tasks that require sequencing and those that don't. Participants will undergo Transcranial Magnetic Stimulation (TMS) while performing these tasks to see how it affects their brain function.See study design

What are the potential side effects?

Potential side effects from TMS may include discomfort at the stimulation site, headache, lightheadedness or seizures in rare cases. Most people tolerate TMS well without serious complications.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 50 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during scan up to 1 hour

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during scan up to 1 hour

This trial's timeline: 3 weeks for screening, Varies for treatment, and during scan up to 1 hour for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

functional magnetic resonance imaging brain activation

Secondary outcome measures

behavioral reaction time (milliseconds)

percent correct of behavioral responses

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Cerebellar StimulationExperimental Treatment4 Interventions

TMS will be administered to the cerebellum on half the trials of a sequence-demanding task, and on half the trials of a non-sequence-demanding task. Task order will be counterbalanced.

Group II: Occipital StimulationActive Control4 Interventions

TMS will be administered to an occipital control region on half the trials of a sequence-demanding task, and on half the trials of a non-sequence-demanding task. Task order will be counterbalanced.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH

2,786 Previous Clinical Trials

2,689,659 Total Patients Enrolled

Johns Hopkins UniversityLead Sponsor

2,266 Previous Clinical Trials

14,837,447 Total Patients Enrolled

John E Desmond, Ph.D.Principal InvestigatorJohns Hopkins University

1 Previous Clinical Trials

17 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research accepting geriatric participants?

"This research is seeking individuals aged 18 and up, yet no older than 50 years old."

Answered by AI

Is it possible for me to enroll in this clinical investigation?

"Enrolment in this experiment requires individuals aged 18-50 who demonstrate effects of cerebellar stimulation on brain activation. Approximately 50 volunteers are needed to participate in the trial."

Answered by AI

Are there any opportunities for new participants in this experiment?

"As reported on clinicaltrials.gov, this specific medical study is not in the process of recruiting patients at present. This trial had an initial posting date of February 1st 2024 and was most recently updated October 25th 2023. Nevertheless, there are currently one other trials that are actively enrolling volunteers for participation."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Cerebellar Involvement in Cognitive Sequencing

2024. "Cerebellar Involvement in Cognitive Sequencing". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06108336.

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