← Back to Search

HMG-CoA Reductase Inhibitor

Atorvastatin and Aspirin for Lynch Syndrome

Q: What other research exists regarding the pharmacological effects of Atorvastatin?

Currently, there are 226 clinical trials in progress for Atorvastatin. Of these experiments, 64 have advanced to Phase 3 of the medical trial process. While most studies take place in China's largest city (Shanghai), this medication is being tested at nearly 4000 sites throughout the world.

Q: Could I be considered an eligible participant in this medical experiment?

This trial is actively enlisting 46 patients with Lynch Syndrome between the ages of 18 and 75. To be considered, participants must abide by the following criteria: they must have attained adulthood (18 years old or older).

Q: How many individuals are included in the scope of this research project?

Affirmative. According to clinicaltrials.gov, this medical experiment is presently in search of subjects since its first post date on September 10th 2018 and was most recently updated on April 6th 2022. 46 volunteers are required from a single study site.

Q: Is this experiment open for enrolment at the moment?

Affirmative. The details hosted on clinicaltrials.gov suggest this medical trial is actively recruiting individuals for participation. This research was first published on September 10th 2018 and the criteria were most recently updated April 6th 2022. Overall, 46 patients are expected to partaken in the study from a single location.

Q: Are participants aged eighty and above being considered for this trial?

To be eligible to take part in this clinical trial, patients must between the age of 18 and 75. However, there are a total of 397 trials that cater for minors and 1198 medical studies which accomodate people over 65 years old.

Q: What medical conditions can be addressed via Atorvastatin therapy?

Atorvastatin is typically prescribed for individuals with clinically evident coronary <a href="https://www.withpower.com/clinical-trials/heart-disease">heart disease</a>. It also has proven success in managing conditions such as synovitis, <a href="https://www.withpower.com/clinical-trials/anxiety">anxiety</a>, and reocclusion of the coronary arteries.

Phase < 1

Waitlist Available

Led By Michael J Hall, MD, MS

Research Sponsored by Fox Chase Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 weeks

Awards & highlights

Study Summary

This trial will study whether atorvastatin, a common cholesterol-lowering drug, can reduce the risk of colorectal cancer in people with Lynch syndrome.

Eligible Conditions

Lynch Syndrome

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Genome-wide expression analyses using RNA-Seq

Proliferation (Ki-67) and apoptosis (active caspase 3) by immunohistochemical staining

Secondary outcome measures

Interventional procedure

Frequency of adverse events among patients administered atorvastatin ± aspirin for 6 weeks

Rate of adherence of healthy patients with Lynch Syndrome to a 6-week of the treatment regimen (atorvastatin ± aspirin).

Trial Design

2Treatment groups

Active Control

Group I: Atorvastatin and AspirinActive Control1 Intervention

Atorvastatin (LIPITOR) 20 milligram tablet and Aspirin 325 mg tablet daily for 6 weeks

Group II: AtorvastatinActive Control1 Intervention

Atorvastatin (LIPITOR) 20 milligram tablet daily for 6 weeks

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Fox Chase Cancer CenterLead Sponsor

227 Previous Clinical Trials

37,463 Total Patients Enrolled

Michael J Hall, MD, MSPrincipal InvestigatorFox Chase Cancer Center

Media Library

Atorvastatin (HMG-CoA Reductase Inhibitor) Clinical Trial Eligibility Overview. Trial Name: NCT04379999 — Phase < 1

Lynch Syndrome Research Study Groups: Atorvastatin and Aspirin, Atorvastatin

Lynch Syndrome Clinical Trial 2023: Atorvastatin Highlights & Side Effects. Trial Name: NCT04379999 — Phase < 1

Atorvastatin (HMG-CoA Reductase Inhibitor) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04379999 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What other research exists regarding the pharmacological effects of Atorvastatin?

"Currently, there are 226 clinical trials in progress for Atorvastatin. Of these experiments, 64 have advanced to Phase 3 of the medical trial process. While most studies take place in China's largest city (Shanghai), this medication is being tested at nearly 4000 sites throughout the world."

Answered by AI

Could I be considered an eligible participant in this medical experiment?

"This trial is actively enlisting 46 patients with Lynch Syndrome between the ages of 18 and 75. To be considered, participants must abide by the following criteria: they must have attained adulthood (18 years old or older)."

Answered by AI

How many individuals are included in the scope of this research project?

"Affirmative. According to clinicaltrials.gov, this medical experiment is presently in search of subjects since its first post date on September 10th 2018 and was most recently updated on April 6th 2022. 46 volunteers are required from a single study site."

Answered by AI

Is this experiment open for enrolment at the moment?

"Affirmative. The details hosted on clinicaltrials.gov suggest this medical trial is actively recruiting individuals for participation. This research was first published on September 10th 2018 and the criteria were most recently updated April 6th 2022. Overall, 46 patients are expected to partaken in the study from a single location."

Answered by AI

Are participants aged eighty and above being considered for this trial?

"To be eligible to take part in this clinical trial, patients must between the age of 18 and 75. However, there are a total of 397 trials that cater for minors and 1198 medical studies which accomodate people over 65 years old."

Answered by AI

What medical conditions can be addressed via Atorvastatin therapy?

"Atorvastatin is typically prescribed for individuals with clinically evident coronary heart disease. It also has proven success in managing conditions such as synovitis, anxiety, and reocclusion of the coronary arteries."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Atorvastatin ± Aspirin in Lynch Syndrome Syndrome

2018. "Atorvastatin ± Aspirin in Lynch Syndrome Syndrome". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04379999.

All > Lipitor