CLINICAL TRIAL

Positive Air Pressure Device for Cancer

Metastatic
Waitlist Available · 18+ · All Sexes · Houston, TX

Non-invasive Ventilation in Reducing the Need for Intubation in Patients With Cancer and Respiratory Failure

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About the trial for Cancer

Eligible Conditions
Neoplasms · Respiratory Insufficiency · Malignant Solid Neoplasms · Hematopoietic and Lymphoid Cell Neoplasm

Treatment Groups

This trial involves 2 different treatments. Positive Air Pressure Device is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Positive Air Pressure Device
DEVICE
Methylprednisolone
DRUG
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Methylprednisolone
DRUG
Oxygen Therapy
PROCEDURE

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Methylprednisolone
FDA approved

Eligibility

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Partial pressure of arterial oxygen (PaO2):fraction of inspired oxygen (FiO2) ratio =< 300 mmHg OR a peripheral capillary oxygen saturation (SaO2):FiO2 =< 357
Have a diagnosed malignancy
Chest radiograph or computed tomography (CT) scan within =< 3 months prior to study enrollment rules out primary or metastatic malignancy in the lungs or pleural space as a significant cause of respiratory insufficiency
Probability of survival is at least 6 months
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Up to 28 days
Screening: ~3 weeks
Treatment: Varies
Reporting: Up to 28 days
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Up to 28 days.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Positive Air Pressure Device will improve 1 primary outcome and 4 secondary outcomes in patients with Cancer. Measurement will happen over the course of Up to 28 days from study inclusion.

Percent of patients who require intubation or meet criteria for intubation
UP TO 28 DAYS FROM STUDY INCLUSION
Fisher's exact test or a chi-squared test will be used to assess the association between two categorical variables. The intubation rate by 28 days and 95% confidence intervals will be estimated for each treatment arm. Logistic regression will be utilized to assess the effect of patient prognostic factors on the intubation rate by 28 days.
UP TO 28 DAYS FROM STUDY INCLUSION
Change in partial pressure of arterial oxygen (PaO2):fraction of inspired oxygen (FiO2) ratio
BASELINE UP TO 28 DAYS
Descriptive statistics, including the mean, standard deviation, median, and range, will be provided. The t-test or Wilcoxon's rank sum test will be used to evaluate the difference between the NIPPV arm and the control arm.
BASELINE UP TO 28 DAYS
Intensive care unit length of stay
UP TO 28 DAYS
Descriptive statistics, including the mean, standard deviation, median, and range, will be provided. The t-test or Wilcoxon's rank sum test will be used to evaluate the difference between the non-invasive positive pressure ventilation (NIPPV) arm and the control arm.
UP TO 28 DAYS
Hospital length of stay
UP TO 28 DAYS
Descriptive statistics, including the mean, standard deviation, median, and range, will be provided. The t-test or Wilcoxon's rank sum test will be used to evaluate the difference between the NIPPV arm and the control arm.
UP TO 28 DAYS
Time to intubation
UP TO 28 DAYS
The Kaplan-Meier method will be used to estimate the time-to-event distribution for each treatment group, and the median time will be provided. The log-rank test will be used to examine the time-to-event distribution of the active treatment group versus that of the control. Time to intubation rate at different time points will be provided by treatment group (i.e. at 7 days, 14 days, 21 days, and 28 days). Since there might be other competing risks for intubation, a competing risk analysis will be performed treating these early events as a competing event for intubation.
UP TO 28 DAYS

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes cancer?

Different cancers are typically caused by different exposures. For example, lung cancer due to smoking is a matter of years of smoke exposure, while [brain cancer](https://www.withpower.com/clinical-trials/brain-cancer) is typically attributed to chemical exposure or radiation exposure.

Anonymous Patient Answer

Can cancer be cured?

Most cancers are not and can not be cured. However, some cancers, such as breast cancer, which have the potential to kill, can be cured without the use of external radiation.

Anonymous Patient Answer

How many people get cancer a year in the United States?

Over 170,000 cases of [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) are diagnosed per year in the US and 15,000-20,000 more cases are diagnosed in women of child-bearing age. The next most common cancer in women is the uterus (around 40,000 cases per year). Lungs, in women, and colorectal cancer, in men, are more common. Over 40,000 of the cases of breast cancer and 20,000 of colorectal cancer each year are attributable to tobacco use. The incidence of brain and pancreatic cancers are increasing markedly.

Anonymous Patient Answer

What is cancer?

Cancers are a collection of diseases characterized by uncontrolled proliferation or invasion of cells. They can be categorized pathologically according to their site of origin. They may also be classified according to patterns of metastases, the time at which they are detected, and their potential response to therapy. For many tumours, the development of diagnostic tests has allowed the identification of specific genetic or epigenetic signatures. In contrast to somatic (such as cancer of the skin and intestine) and hereditary (such as cancer syndromes) cancers, information on the molecular events responsible is usually lacking for carcinogenesis in cancer. Cancerous tumoral cells have to integrate multiple genetic and epigenetic changes in order to make their full cancer phenotype.

Anonymous Patient Answer

What are common treatments for cancer?

The treatments for cancer range from surgery alone for those with colorectal cancer, to all-encompassing therapies for cancer that include all of the following: surgery, chemotherapy, radiation therapy and targeted therapies. Even so, it remains difficult to provide efficient treatment for a whole group of people with cancer. Treatment is better provided, and better quality assurance is required in the form of guidelines.

Anonymous Patient Answer

What are the signs of cancer?

Symptoms of cancer can be very subtle and vary between individuals. Although cancer is most commonly detected by physical examination, other forms of medical testing such as X-ray and CT scans can be employed to confirm the presence of disease. If symptoms are not adequately explained by the physical examination, further medical imaging tests such as magnetic resonance imaging (MRI), positron emission tomography (PET) scans, and ultrasound (using the sonographic shadowing technique called US) may be required.\n

Anonymous Patient Answer

Does cancer run in families?

Most of the families in this study with cancer are non-Ashkenazi or of Ashkenazi Jewish descent. For the families of Ashkenazi or Ashkenazi Jewish descent, the higher proportion of cases among women may be related to the fact that women are more likely than men to be exposed to environmental tobacco smoke from other members of the family. The lower frequency of cancer among Ashkenazi men may be caused by factors associated with Ashkenazi Jewish heritage, such as greater socioeconomic status, better access to cancer screening, and less exposure to environmental tobacco smoke than are men in other ethnically diverse groups.

Anonymous Patient Answer

Has methylprednisolone proven to be more effective than a placebo?

Results from a recent paper, using a large scale, double-blind trial to assess the effects of a single dose of methylprednisolone on patients with nonemergent severe burns, confirms its potential effectiveness as an adjunct to other modalities including hyperalgesia, as a modulator of the inflammatory response, and, as seen in our previous study evaluating the effects of methylprednisolone on burn patients with pneumonia.

Anonymous Patient Answer

What are the latest developments in methylprednisolone for therapeutic use?

In contrast to what has been reported in the literature on the therapeutic use of methylprednisolone, this analysis of the data revealed that the results of most clinical trials were highly similar.

Anonymous Patient Answer

Have there been any new discoveries for treating cancer?

There have been some new discoveries and clinical trials being conducted focusing on cancer. It is possible that new treatments for cancer may be emerging in the near future and the patients need to know about these studies. I would say that there is still a lot yet to be discovered concerning cancer treatment

Anonymous Patient Answer

What is the average age someone gets cancer?

On average, cancer is 2.5 years earlier when an individual is female than when they are male. These gender differences can also be seen when looking at the timing and incidence of cancer

Anonymous Patient Answer

What is the primary cause of cancer?

If there isn't another disease that can cause a given cancer at a young age, then there is a problem of the primary cause of cancer. However, when this disease is found, it would be important to make sure that there aren't any other diseases that would cause it at a younger age. For example, it was known that I have cancer of colon. I underwent surgery and had a chemotherapy for about 3 months. After that, there was a few months of chemotherapy. That's it, and then I didn't have any new symptoms. I'm now a child. That's when my parents found out that my father had cancer a couple of years ago.

Anonymous Patient Answer
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