← Back to Search

Alpha-2 Adrenergic Agonist

Clonidine + Hydrochlorothiazide for High Blood Pressure (SELECT Trial)

Q: What indications is Clonidine usually prescribed to treat?

Clonidine is commonly employed to address the effects of left ventricular hypertrophy, in addition to conditions such as edema, <a href="https://www.withpower.com/clinical-trials/adhd">ADHD</a> and pheochromocytomas.

Q: What is the cap on recruitment for this clinical trial?

Affirmative. Clinicaltrials.gov makes it clear that this medical experiment, which was initially publicized on June 1st 2021, is actively recruiting individuals for participation. A total of 78 participants will be accepted at two different clinical sites.

Q: Are participants currently being enrolled for this research?

Affirmative. The clinicaltrials.gov record for this trial indicates that it is recruiting participants, with an initial posting on June 1st 2021 and most recent update made on the 8th of June. 78 individuals are being recruited from two research centers.

Q: Who is eligible to join this clinical trial?

In order to be included in this research effort, applicants must possess the symptoms of stiffness and aortic issues while falling within the age range of 60-85. This medical trial is looking for a total of 78 participants.

Q: Does this experiment accommodate persons aged thirty and above?

For this clinical trial, the upper and lower age boundaries are 85 years old and 60 years old respectively.

Q: What other investigations have examined the application of Clonidine?

Presently, there are 29 studies conducted on the efficacy of Clonidine. 11 of these investigations have advanced to Phase 3 trials and 221 centres around the globe are recruiting patients for this medication. Of <a href="https://www.withpower.com/clinical-trials/all">all</a> locations, Lexington <a href="https://www.withpower.com/clinical-trials/kentucky">Kentucky</a> is particularly invested in research surrounding Clonidine.

Phase < 1

Recruiting

Led By Gary Pierce, PhD

Research Sponsored by University of Iowa

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

If subject is on antihypertensive medications, they will stop taking medication for a one-week washout period after Visit 1 before they return for Visit 2. They will come in at day 3 and day 7 of the one-week washout for a BP reading, to confirm that systolic BP is <160 mmHg.

Age 60-85

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and after 4 weeks

Awards & highlights

SELECT Trial Summary

This trial will study if nerve activity from the brain contributes to the stiffening of blood vessels in older adults, which can lead to cardiovascular disease.

Who is the study for?

This trial is for non-smoking adults aged 60-85 with untreated or treated stage 1 or 2 isolated systolic hypertension. Participants must be clinically healthy and not on certain medications like aspirin, NSAIDs, vitamins, or supplements. Women should be postmenopausal without hormone therapy. Those with a history of serious health conditions such as heart disease, diabetes, cancer are excluded.Check my eligibility

What is being tested?

The study tests if reducing nerve activity from the brain can decrease stiffness in large arteries to prevent cardiovascular diseases. It compares the effects of Clonidine (a blood pressure medication) and Hydrochlorothiazide (a diuretic) against a placebo in older adults with high systolic blood pressure.See study design

What are the potential side effects?

Possible side effects include dizziness, dry mouth, fatigue due to Clonidine; dehydration or electrolyte imbalance from Hydrochlorothiazide; and no active treatment-related side effects from the placebo.

SELECT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I can stop my blood pressure medication for a week and have a systolic BP under 160 mmHg.

Select...

I am between 60 and 85 years old.

SELECT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and after 4 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and after 4 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and after 4 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in carotid-femoral pulse wave velocity

Secondary outcome measures

Change in carotid distensibility index

Change in carotid flow pulsatility index

Change in carotid intimal medial thickness (IMT)

Side effects data

From 2009 Phase 4 trial • 12 Patients • NCT00370838

50%

Tired/sleepy

40%

Anxious

30%

Fatigue

30%

Aggression

20%

Stomache ache

20%

Lethargic

20%

Insomnia

20%

Irritability

10%

Dry mouth

10%

Dizzy

10%

Sleepwalking

10%

Sad/depressed

100%

80%

60%

40%

20%

Study treatment Arm

Clonidine

Levetiracetam

SELECT Trial Design

3Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: ClonidineExperimental Treatment1 Intervention

0.2 mg/day oral

Group II: HydrochlorothiazideActive Control1 Intervention

37.5 mg/day oral

Group III: PlaceboPlacebo Group1 Intervention

Placebo

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Clonidine

FDA approved

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of IowaLead Sponsor

446 Previous Clinical Trials

879,424 Total Patients Enrolled

Gary Pierce, PhDPrincipal InvestigatorUniversity of Iowa

2 Previous Clinical Trials

77 Total Patients Enrolled

Media Library

Clonidine (Alpha-2 Adrenergic Agonist) Clinical Trial Eligibility Overview. Trial Name: NCT04423627 — Phase < 1

Aortic Stiffness Research Study Groups: Placebo, Clonidine, Hydrochlorothiazide

Aortic Stiffness Clinical Trial 2023: Clonidine Highlights & Side Effects. Trial Name: NCT04423627 — Phase < 1

Clonidine (Alpha-2 Adrenergic Agonist) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04423627 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What indications is Clonidine usually prescribed to treat?

"Clonidine is commonly employed to address the effects of left ventricular hypertrophy, in addition to conditions such as edema, ADHD and pheochromocytomas."

Answered by AI

What is the cap on recruitment for this clinical trial?

"Affirmative. Clinicaltrials.gov makes it clear that this medical experiment, which was initially publicized on June 1st 2021, is actively recruiting individuals for participation. A total of 78 participants will be accepted at two different clinical sites."

Answered by AI

Are participants currently being enrolled for this research?

"Affirmative. The clinicaltrials.gov record for this trial indicates that it is recruiting participants, with an initial posting on June 1st 2021 and most recent update made on the 8th of June. 78 individuals are being recruited from two research centers."

Answered by AI

Who is eligible to join this clinical trial?

"In order to be included in this research effort, applicants must possess the symptoms of stiffness and aortic issues while falling within the age range of 60-85. This medical trial is looking for a total of 78 participants."

Answered by AI

Does this experiment accommodate persons aged thirty and above?

"For this clinical trial, the upper and lower age boundaries are 85 years old and 60 years old respectively."

Answered by AI

What other investigations have examined the application of Clonidine?

"Presently, there are 29 studies conducted on the efficacy of Clonidine. 11 of these investigations have advanced to Phase 3 trials and 221 centres around the globe are recruiting patients for this medication. Of all locations, Lexington Kentucky is particularly invested in research surrounding Clonidine."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Sympathetic Regulation of Large Artery Stiffness in Humans With ISH

Gary L. Pierce, PhD 2021. "Sympathetic Regulation of Large Artery Stiffness in Humans With ISH". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04423627.

All > High Blood Pressure