Ginger for Nerve Pain
(Ginger-NP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether ginger can alleviate nerve pain, specifically in individuals with chronic sciatica, where pain radiates from the lower back through the legs. Participants will receive either ginger supplements (ginger root extract) or a placebo for eight weeks to assess ginger's effects on gut health, inflammation, and pain levels. The trial aims to understand the connection between gut health and nerve pain. Individuals with sciatica who have experienced pain for at least three months might be suitable for this study. As a Phase 2 trial, this research focuses on measuring the treatment's effectiveness in an initial, smaller group, offering participants a chance to contribute to important scientific findings.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are taking medication that affects blood clotting or platelet function.
Is there any evidence suggesting that ginger root extract is likely to be safe for humans?
Research shows that ginger root extract is generally safe for people. Previous studies on ginger for pain relief have shown promising results with few side effects. In some studies, only a small number of people reported mild negative effects. Although ginger is not yet approved specifically for nerve pain, it has been safely used for other purposes. This trial is in an early stage, so more research is needed to fully understand its safety and effectiveness for nerve pain.12345
Why do researchers think this study treatment might be promising for nerve pain?
Unlike other treatments for nerve pain, which often rely on medications like gabapentin or opioids, ginger root extract offers a natural alternative. Researchers are excited about ginger because it contains compounds with anti-inflammatory and antioxidant properties that might help reduce nerve pain differently than traditional drugs. Additionally, ginger root extract is generally well-tolerated, potentially offering a treatment with fewer side effects. This makes it an appealing option for those looking for more holistic approaches to managing nerve pain.
What evidence suggests that ginger root extract might be an effective treatment for sciatica?
Research has shown that ginger root extract can help reduce nerve pain. In this trial, participants in the Ginger group will receive 2,000 mg of ginger root extract daily for 8 weeks. Studies have found that ginger, particularly its active components like gingerol, reduces pain behaviors in animals with nerve pain. It also appears to decrease inflammation in the nervous system, which can help relieve pain. Ginger's effects may involve the gut-brain connection, currently under study for its role in managing pain. These findings suggest that ginger might be a promising option for easing nerve pain due to its ability to reduce pain and inflammation.36789
Are You a Good Fit for This Trial?
This trial is for individuals experiencing sciatic nerve pain. Participants must be diagnosed with sciatica to qualify. The study seeks to understand how ginger affects gut-brain interactions in relation to this condition.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either 2000 mg of ginger root extract or placebo daily for 8 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Ginger Root Extract
Find a Clinic Near You
Who Is Running the Clinical Trial?
Leslie Shen
Lead Sponsor