This trial is evaluating whether Active biphasic pulse stimulation---VIN Biphasic will improve 2 primary outcomes and 3 secondary outcomes in patients with Familial Tremor. Measurement will happen over the course of up to 1 hour.
This trial requires 70 total participants across 2 different treatment groups
This trial involves 2 different treatments. Active Biphasic Pulse Stimulation---VIN Biphasic is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
Family history of tremor is not a significant risk factor. However, a family history may identify a subgroup of patients who can benefit from diagnostic tools, such as electrophysiologic studies or genetic testing.
The prevalence of FT is likely variable across the US population, and no systematic study has yet used an objective method to evaluate the prevalence of FT in US populations. One review of studies in Canada found no prevalence estimates for FT, and another of studies in Texas found estimates of 3.7% to 6.2%. The prevalence in the authors' institution is 4.4%. Given the widespread use of EMG by neurologists and the general interest in FT, further studies to define the prevalence of FT and evaluate other aspects of its genetic heterogeneity is warranted.
tremor in family members is a sign of inherited tremor, not a new symptom. In familial tremor, other symptoms of inherited tremor may also occur. The diagnosis of familial tremor should be based on the family history, rather than on physical examinations or neurologic examinations by family physicians.
Tremor can be characterized by bradykinesia with rapid alternating movement, typically from shoulder to finger. There is no known curative therapy unless the tremor can be controlled with medications or other treatments.\n
The two most obvious and commonly used treatments for familial tremor are levodopa and dopamine agonists. Both treatments (Levodopa and Dopamine agonists) are commonly used as the initial treatment for kindreds of tremor who have had a family history of tremor and whose tremor has not been responsive to medication and/or surgery. However, levodopa and dopamine agonists do have advantages and disadvantages compared to surgery.
The familial tremor phenotype could, in a limited number of patients, be cured by botulinum-A injection. This must be interpreted with caution, requiring the evaluation of alternative treatments in all patients.
The active biphasic pulse stimulation and vin biphasic stimulation have comparable effects of reducing active myoclonus, tremor amplitude, and muscle fatigue; in addition, they have similar adverse effects.
Data from a recent study of this study show that the activity of biphasic VS improves the function of the VB. Data from a recent study may be clinically important because the presence of increased activity of the VB can result in more efficient stimulation of the VIB, improving the efficacy of the biphase protocol.
Results from a recent clinical trial demonstrate that active vin biphasic pulse stimulation can be used to abort or abortise tremor if a previously unresponsive tremor is present; when treating previously unresponsive chronic (postpyramidal) dystonia tremor, vin biphasic pulse stimulation may be an important complementary tool.
Compared with vin monophasic stimulation, vin biphasic stimulation did not improve motor and non-motor functioning in adult patients with FT, but did seem to improve mood and QoL, potentially by activating peripheral vestibular systems.
In the world of medicine, there are fewer and fewer medical procedures that have been studied and described; as well as fewer discoveries made based on them. However, we should not get discouraged; we should continue to look the way we've looked before: and try to find the simplest, best-tasting, and simplest-to-make [drinks] to treat FTM.