CLINICAL TRIAL

electrophysiological data collection for Parkinson Disease

Recruiting · 18+ · All Sexes · Boston, MA

Cortical-Basal Ganglia Speech Networks

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About the trial for Parkinson Disease

Eligible Conditions
Essential Tremor · Dystonia · Parkinson Disease

Treatment Groups

This trial involves 2 different treatments. Electrophysiological Data Collection is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
electrophysiological data collection
OTHER
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Subjects 18-85 years old
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Duration of single DBS surgery
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Duration of single DBS surgery.
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Measurement Requirements

This trial is evaluating whether electrophysiological data collection will improve 1 primary outcome in patients with Parkinson Disease. Measurement will happen over the course of Duration of single DBS surgery.

The number of subjects providing the interpretable speech related electrophysiological data collection.
DURATION OF SINGLE DBS SURGERY
The number of subjects providing the interpretable speech related electrophysiological data during DBS surgery.

Who is running the study

Principal Investigator
R. M. R.
Robert Mark Richardson, Director of Functional Neurosurgery
Massachusetts General Hospital

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is parkinson disease?

The symptoms of PD include impaired movement (bradykinesia), slowness (bradytremor) of movement initiation and termination and gait and postural instability. While PD symptoms vary from individual to individual and depending on what part of the body the PD applies to, there are common symptoms that are common to all cases of Parkinson's.

Anonymous Patient Answer

What are common treatments for parkinson disease?

Many Parkinson's patients are treated with dopamine agonists (e.g., bromocriptine, pramipexole) that relieve symptoms. Other agents (e.g., selegiline, ropinirole) may also be prescribed. Cognitive therapies are commonly used to help patients manage Parkinson's disease symptoms, and cognitive therapies to help with motor symptoms may also be prescribed. Antidepressants (e.g., selective serotonin reuptake inhibitors or serotonin/norepinephrine reuptake inhibitors) are usually prescribed to help treat depression and improve motor symptoms such as tremor, rigidity, and slowness of movement.

Anonymous Patient Answer

How many people get parkinson disease a year in the United States?

About 200,000 people are diagnosed with Parkinson's disease a year in the United States. It is the number one cause of parkinsonism (Parkinson's disease, dementia with Lewy bodies, Parkinson's disease variant syndromes, and other parkinsonism-dementia syndromes) in the United States.\n

Anonymous Patient Answer

What are the signs of parkinson disease?

[Some of the signs of Parkinson's disease are (a) trembling, (b) slow movements, (c) changes in skin pigmentation such as [red lips, darkening of the area around the eyes, and eyebrows, and (d) the difficulty the person has in getting up suddenly or suddenly wanting to get up. Use Power to find out more about Parkinson disease symptoms and risks by looking at clinical trials for Parkinson's disease.

Anonymous Patient Answer

What causes parkinson disease?

What causes parkinson disease? It is unlikely that a single factor will cause Parkinson's disease. This is likely to be due to an imbalance of multiple environmental factors acting together. These factors could include factors such as infection, pesticides and other neurotoxins, genetics, metabolic changes, and hormonal irregularities. These factors may work in an additive mode to cause damage to the nerves responsible for coordinating movement. This damage in turn can cause a dopamine deficiency. This deficiency is a factor in the development of Parkinson's disease. The exact cause is not yet known, but there are multiple theories that have been proposed to explain why Parkinson's disease develops. The exact mechanism underlying the cause of Parkinson's disease is also still unknown.

Anonymous Patient Answer

Can parkinson disease be cured?

Though the concept of remission is not a current medical requirement for PD diagnosis in the United States, a sizable minority of patients may have PD with few if any clinical symptoms.

Anonymous Patient Answer

What does electrophysiological data collection usually treat?

This case series provides the clinical, electrophysiological, and electrographic context of the diagnostic work-up, with the conclusion of a definite treatment plan. This case series shows that electrophysiological data of unknown clinical significance are often reported and treated. Patient education is imperative for electrophysiology data interpretation and treatment.

Anonymous Patient Answer

Does electrophysiological data collection improve quality of life for those with parkinson disease?

This single study has shown that EMG-BCNAP measurement is a useful tool to assess the degree of tremor in individuals with PD, and to document the progressive change in tremor activity during the course of the disease after dopaminergic treatments.

Anonymous Patient Answer

Is electrophysiological data collection typically used in combination with any other treatments?

In our study there was a substantial prevalence of abnormal electrophysiological data recorded on multiple occasions. While the findings were more pronounced in young participants, the effect of multiple recordings and/or use of treatments other than treatment of PD was not evident.

Anonymous Patient Answer

Is electrophysiological data collection safe for people?

The high rates of adverse events reported when EMG data collection is compared to data collection with an EEG suggests that EMG-based neuromuscular monitoring is not safe for people with a higher grade of mobility impairment who are in a more acute care environment or who have had a major recent surgery.

Anonymous Patient Answer

What is the average age someone gets parkinson disease?

Findings show the overall mean age of onset of PD is 65.3. The greatest number of reported cases took place near the age of 60. Results from a recent clinical trial do not provide support for the hypothesis that PD develops later in women than men. [A 2013 study (http://amjnp.gnm-gsa.net/doi/10.1017/S0103204612000829) found that women who had PD had a worse survival rate than men. You can find this recent PD clinical trial looking of what treatment is best for your condition by using [Power], which allows you to search trials tailored to your condition or location via [Diabetes.journal.

Anonymous Patient Answer

Have there been any new discoveries for treating parkinson disease?

There are new discoveries for treating Parkinson disease. Stereotactic radiosurgery has revolutionized the treatment of this disorder. The future seems to be in cellular or gene therapies and gene therapy for Parkinson's disease, which may hopefully allow a cure in the future.

Anonymous Patient Answer
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