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Deep Brain Stimulation for Parkinson's Disease

N/A
Waitlist Available
Led By Warren M Grill, PhD
Research Sponsored by Duke University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) or Multiple Sclerosis (MS)
Neurologically stable
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1
Awards & highlights

Study Summary

This trial is testing different types of deep brain stimulation to see which is most effective in treating Parkinson's, essential tremor, and multiple sclerosis. The results will help design more effective stimulation patterns and aid in understanding how DBS works.

Who is the study for?
This trial is for individuals with Parkinson's Disease, Essential Tremor, or Multiple Sclerosis who are neurologically stable and scheduled for Deep Brain Stimulation surgery. Participants must understand the study and consent form. Those unable to perform motor tasks or tolerate medication withdrawal, or with ineffective DBS are excluded.Check my eligibility
What is being tested?
The study measures how non-regular deep brain stimulation patterns affect motor symptoms and neural activity in patients with PD, ET, or MS. The goal is to develop more effective DBS treatments by understanding its mechanisms better.See study design
What are the potential side effects?
While not explicitly listed here, potential side effects of DBS can include headache, seizure, confusion, difficulty concentrating, mood changes and hardware complications like infection.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with Parkinson's, Essential Tremor, or Multiple Sclerosis.
Select...
My neurological condition is stable.
Select...
I am scheduled for DBS surgery or to have my DBS battery replaced.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Fingers
Neural Activity
Tremor Accelerometry
Secondary outcome measures
Electrode Location

Trial Design

2Treatment groups
Experimental Treatment
Group I: Therapeutic Stimulation PatternsExperimental Treatment1 Intervention
This group will receive temporal patterns of stimulation that are designed to suppress oscillatory neural activity at theta- or beta-frequencies. These patterns are hypothesized to alleviate motor symptoms.
Group II: Symptogenic Stimulation PatternsExperimental Treatment1 Intervention
This group will receive symptogenic patterns of stimulation that are designed to exacerbate oscillatory neural activity at theta- or beta-frequencies. These patterns are hypothesized to exacerbate motor symptoms.

Find a Location

Who is running the clinical trial?

Boston Scientific CorporationIndustry Sponsor
718 Previous Clinical Trials
932,768 Total Patients Enrolled
Duke UniversityLead Sponsor
2,358 Previous Clinical Trials
3,419,889 Total Patients Enrolled
National Institute of Neurological Disorders and Stroke (NINDS)NIH
1,339 Previous Clinical Trials
649,210 Total Patients Enrolled

Media Library

Symptogenic Stimulation Patterns Clinical Trial Eligibility Overview. Trial Name: NCT02553525 — N/A
Parkinson's Disease Research Study Groups: Symptogenic Stimulation Patterns, Therapeutic Stimulation Patterns
Parkinson's Disease Clinical Trial 2023: Symptogenic Stimulation Patterns Highlights & Side Effects. Trial Name: NCT02553525 — N/A
Symptogenic Stimulation Patterns 2023 Treatment Timeline for Medical Study. Trial Name: NCT02553525 — N/A
Parkinson's Disease Patient Testimony for trial: Trial Name: NCT02553525 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who has the opportunity to participate in this experiment?

"This clinical trial is recruiting 180 participants who have a familial tremor, aged between 21 and 80 years old. Other requirements for the study include being scheduled to undergo Deep Brain Stimulation (DBS) electrode implant or implanted pulse generator (IPG) replacement surgery, having neurological stability, and comprehension of both the study and consent document."

Answered by AI

Does this medical experiment accept participants who are of legal age?

"Eligible patients for this trial must be between 21 and 80 years old. There are 51 studies designed for minors and 757 clinical trials specific to elderly people."

Answered by AI

Are there any opportunities for new participants to join this research?

"Based on the information found in clinicaltrials.gov, this medical trial is no longer accepting patients. Initially posted on June 2nd 2016 and last updated May 13th 2022, sadly there are presently no additional enrolment opportunities available for this study; however, 910 other studies are open to recruitment at present."

Answered by AI

Who else is applying?

What state do they live in?
Georgia
North Carolina
How old are they?
18 - 65
What site did they apply to?
Duke University
Emory University
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
1
3+

Why did patients apply to this trial?

Inherited ET from my father, only siblings out of 5. On a medicine an getting Botox neck Injections. Hands and arms still very shaky.
PatientReceived 1 prior treatment
Currently taking carbidopa/levodopa three times daily. It is not reducing my right arm tremor. So I am interested in alternate therapies.
PatientReceived 1 prior treatment

What questions have other patients asked about this trial?

I live in Greensboro, 75 minutes away. Will I be compensated for travel expenses?
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Effects of Stimulation Patterns of Deep Brain Stimulation
2016. "Effects of Stimulation Patterns of Deep Brain Stimulation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02553525.
All > Multiple Sclerosis > Essential Tremor
~41 spots leftby Sep 2026
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