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Deep Brain Stimulation for Parkinson's Disease

N/A

Waitlist Available

Led By Warren M Grill, PhD

Research Sponsored by Duke University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) or Multiple Sclerosis (MS)

Neurologically stable

Must not have

Inability to execute the motor tasks during the study

Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications

Timeline

Screening 3 weeks

Treatment Varies

Follow Up day 1

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing different types of deep brain stimulation to see which is most effective in treating Parkinson's, essential tremor, and multiple sclerosis. The results will help design more effective stimulation patterns and aid in understanding how DBS works.

Who is the study for?

This trial is for individuals with Parkinson's Disease, Essential Tremor, or Multiple Sclerosis who are neurologically stable and scheduled for Deep Brain Stimulation surgery. Participants must understand the study and consent form. Those unable to perform motor tasks or tolerate medication withdrawal, or with ineffective DBS are excluded.

What is being tested?

The study measures how non-regular deep brain stimulation patterns affect motor symptoms and neural activity in patients with PD, ET, or MS. The goal is to develop more effective DBS treatments by understanding its mechanisms better.

What are the potential side effects?

While not explicitly listed here, potential side effects of DBS can include headache, seizure, confusion, difficulty concentrating, mood changes and hardware complications like infection.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with Parkinson's, Essential Tremor, or Multiple Sclerosis.

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My neurological condition is stable.

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I am scheduled for DBS surgery or to have my DBS battery replaced.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I cannot perform certain physical tasks required in the study.

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I cannot stop taking my Parkinson's or tremor medications.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day 1

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day 1

This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Fingers

Neural Activity

Tremor Accelerometry

Secondary study objectives

Electrode Location

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Therapeutic Stimulation PatternsExperimental Treatment1 Intervention

This group will receive temporal patterns of stimulation that are designed to suppress oscillatory neural activity at theta- or beta-frequencies. These patterns are hypothesized to alleviate motor symptoms.

Group II: Symptogenic Stimulation PatternsExperimental Treatment1 Intervention

This group will receive symptogenic patterns of stimulation that are designed to exacerbate oscillatory neural activity at theta- or beta-frequencies. These patterns are hypothesized to exacerbate motor symptoms.

0 / 5Eligibility criteria met