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Deep Brain Stimulation for Parkinson's Disease

N/A
Waitlist Available
Led By Warren M Grill, PhD
Research Sponsored by Duke University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) or Multiple Sclerosis (MS)
Neurologically stable
Must not have
Inability to execute the motor tasks during the study
Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1
Awards & highlights

Summary

This trial is testing different types of deep brain stimulation to see which is most effective in treating Parkinson's, essential tremor, and multiple sclerosis. The results will help design more effective stimulation patterns and aid in understanding how DBS works.

Who is the study for?
This trial is for individuals with Parkinson's Disease, Essential Tremor, or Multiple Sclerosis who are neurologically stable and scheduled for Deep Brain Stimulation surgery. Participants must understand the study and consent form. Those unable to perform motor tasks or tolerate medication withdrawal, or with ineffective DBS are excluded.Check my eligibility
What is being tested?
The study measures how non-regular deep brain stimulation patterns affect motor symptoms and neural activity in patients with PD, ET, or MS. The goal is to develop more effective DBS treatments by understanding its mechanisms better.See study design
What are the potential side effects?
While not explicitly listed here, potential side effects of DBS can include headache, seizure, confusion, difficulty concentrating, mood changes and hardware complications like infection.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with Parkinson's, Essential Tremor, or Multiple Sclerosis.
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My neurological condition is stable.
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I am scheduled for DBS surgery or to have my DBS battery replaced.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I cannot perform certain physical tasks required in the study.
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I cannot stop taking my Parkinson's or tremor medications.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Fingers
Neural Activity
Tremor Accelerometry
Secondary outcome measures
Electrode Location

Trial Design

2Treatment groups
Experimental Treatment
Group I: Therapeutic Stimulation PatternsExperimental Treatment1 Intervention
This group will receive temporal patterns of stimulation that are designed to suppress oscillatory neural activity at theta- or beta-frequencies. These patterns are hypothesized to alleviate motor symptoms.
Group II: Symptogenic Stimulation PatternsExperimental Treatment1 Intervention
This group will receive symptogenic patterns of stimulation that are designed to exacerbate oscillatory neural activity at theta- or beta-frequencies. These patterns are hypothesized to exacerbate motor symptoms.

Find a Location

Who is running the clinical trial?

Boston Scientific CorporationIndustry Sponsor
724 Previous Clinical Trials
933,943 Total Patients Enrolled
Duke UniversityLead Sponsor
2,394 Previous Clinical Trials
3,059,306 Total Patients Enrolled
National Institute of Neurological Disorders and Stroke (NINDS)NIH
1,349 Previous Clinical Trials
647,997 Total Patients Enrolled

Media Library

Symptogenic Stimulation Patterns Clinical Trial Eligibility Overview. Trial Name: NCT02553525 — N/A
Parkinson's Disease Research Study Groups: Symptogenic Stimulation Patterns, Therapeutic Stimulation Patterns
Parkinson's Disease Clinical Trial 2023: Symptogenic Stimulation Patterns Highlights & Side Effects. Trial Name: NCT02553525 — N/A
Symptogenic Stimulation Patterns 2023 Treatment Timeline for Medical Study. Trial Name: NCT02553525 — N/A
Parkinson's Disease Patient Testimony for trial: Trial Name: NCT02553525 — N/A
~37 spots leftby Sep 2026