This trial is evaluating whether Oral sodium supplementation will improve 3 primary outcomes and 10 secondary outcomes in patients with Obesity. Measurement will happen over the course of 7 days.
This trial requires 55 total participants across 2 different treatment groups
This trial involves 2 different treatments. Oral Sodium Supplementation is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"Findings from a recent study showed improvements in some aspects of QoL for patients with chronobiology disorders in addition to some general improvements. More research of oral salt supplementation is indicated for patients with chronobiology disorders." - Anonymous Online Contributor
"Patients with severe circadian rhythm disorders have a wide variety of treatment options, from medical treatments (light therapy etc.), to more invasive solutions like surgery. All of these options are often necessary for patient satisfaction depending on their condition. Chronotherapy seems to have a positive outcome, but further studies are still needed to prove this positive response." - Anonymous Online Contributor
"Current medical theory states that chronic, and preferably idiopathic, disorders can be cured in an unspecified period if treatment begins as early as possible. However, this will usually have to be done by means of a medical procedure which has an unpleasant risk to a human being. Chronobiology theory states that chronic, and ideally idiopathic, disorders are always chronic. Theories and data suggest that chronic, and preferably idiopathic, disorders will have their most unpleasant symptoms at certain periods in life. Therefore, if proper treatment is provided to patients with chronobiology diseases that are considered chronic, and ideally idiopathic, it is possible that these diseases will also be cured." - Anonymous Online Contributor
"Chronobiology is a disorder that is characterized by an individual's circadian rhythm that is disrupted. Chronobiology is the study of this disturbance. Chronobiologists may investigate the effects of the circadian system on the organism's development, behavior, physiology, and pathophysiology. Chronobiologists look to find new therapies for chronobiology disorders in the hope of curing and/or improving the living standards of patients." - Anonymous Online Contributor
"Recent findings found that chronobiology disorders affect an estimated 13 million adults in the U.S. each year. Although the reasons behind development of the disorders remain unclear and their prevalence is still unknown, we believe that these data highlight the need for improved clinical awareness and better management of patients with chronobiology disorders." - Anonymous Online Contributor
"The prevalence of chronobiology disorders is not low. However, the present-day knowledge of chronobiology is poor. In addition, there is not a standard protocol for investigating chronobiology disorders. Therefore, it is difficult to organize a study on the prevalence of chronobiology disorders. It may be necessary to establish a database of chronobiology disorders during the next few years." - Anonymous Online Contributor
"Chronobiology disorders, such as circadian rhythm sleep disorder (CRDSD), have many signs similar to other sleep disorders, such as insomnia. This review lists the main signs in CRDSD in chronological order with the age range of onset. Circadian rhythm sleep disorder symptoms can occur in people of all ages. When symptoms begin to appear, a comprehensive assessment and referral to an sleep specialist is advised. Circadian rhythm sleep disorder has many similar symptoms to other sleep disorders. These symptoms often appear during childhood to teen years. Older people may not have time for them. One is not to blame the circadian rhythm, it is how someone perceives it. Sleep disorders can disrupt the body's natural cycle. This can result in medical problems." - Anonymous Online Contributor
"Oral NS was significantly more effective than placebo and placebo-controlled-sodium in preventing the loss of renal function (eGFR decrease and a urinary albumin increase) caused by chronic hypoalbuminemia in dialysis patients." - Anonymous Online Contributor
"This report suggests that trials of treatments for chronic diseases that have not been studied for a number of years offer the greatest chances of achieving significant results. The potential value of evaluating treatments for chronic conditions that would never be accepted to current clinical practices awaits evaluation." - Anonymous Online Contributor
"Current evidence does not support concerns that people will be adversely affected by long term or daily oral sodium supplementation. There exists a small but significant effect of salt on plasma renin activity, but the magnitude of these effects is small and may be clinically irrelevant." - Anonymous Online Contributor
"These investigators have contributed little to the treatment for chronobiology disorders, and most drugs and other therapies currently available to treat these patients have no solid evidence base to support their use. Clinicians are now turning to a small, new group of drugs that have shown promise in small trials. The development of this group of treatments should continue, even though such treatment appears not to be justified from a clinical perspective." - Anonymous Online Contributor
"Oral sodium supplementation in healthy volunteers increases resting cerebral blood flow velocity and cerebral blood flow in both young and elderly, as measured with transcranial Doppler ultrasonography. In addition, the drug improves cerebral blood flow velocity and cerebral blood flow in patients with high cerebral vascular resistance or a history of stroke; thus, oral sodium supplementation might be a beneficial tool in the management of cerebral vascular insufficiency." - Anonymous Online Contributor