Triple Negative Breast Cancer Clinical Trials
Here are the 6 most popular medical studies for triple negative breast cancer
Procedure
NUV-868 + Olaparib/Enzalutamide for Solid Tumors
This trial is testing a new drug, NUV-868, for safety and efficacy in patients with advanced solid tumors. The drug will be taken orally, either as a monotherapy or in combination with other drugs olaparib or enzalutamide, in 28-day cycles. The trial will continue until the disease progresses, there are unacceptable side effects, the patient withdraws consent, or the trial is terminated.
Monoclonal Antibodies
Pembrolizumab/Vibostolimab Co-Formulation for Solid Tumors
“ My mother in law is having an advanced metastatic cancer of an endometrial origin. She is currently struggling with RBC’s count so I was not sure if this means her organs are functional (hence my reply with ‘unsure’).”
Virus Therapy
TAK-676 + Pembrolizumab for Multiple Cancers
This trial is testing a combination of two immunotherapy drugs, TAK-676 and pembrolizumab, to see if they can improve outcomes for people with non-small cell lung cancer, triple-negative breast cancer, and squamous cell carcinoma of the head and neck.
Monoclonal Antibodies
Pembrolizumab + BT8009 for Nectin-4 Expressing Advanced Malignancies
This trial is testing a new drug called BT8009, either alone or combined with another drug called nivolumab, in people with advanced solid tumors. The goal is to see if it is safe and effective.
Monoclonal Antibodies
AZD8701 +/- Durvalumab for Advanced Solid Tumors
This trial is testing a new drug, AZD8701, to see if it is safe and effective in treating certain types of solid tumors. The drug will be tested alone and in combination with another drug, durvalumab.
Monoclonal Antibodies
Pembrolizumab + Mifepristone for HER2-negative Breast Cancer
This trial is testing a combination of two drugs to treat advanced breast cancer. The first part of the trial will test the safety of the combination in ten patients. If the combination is safe, the trial will expand to include more patients.
Popular filter options for triple negative breast cancer trials
Metastatic Triple Negative Breast Cancer Clinical Trials
View 98 metastatic triple negative breast cancer medical studies.
Monoclonal Antibodies
Combination Therapy for Metastatic Triple Negative Breast Cancer
This trial will test the effectiveness of durvalumab, a new immunotherapy drug, in combination with other cancer treatments, for people with first-line metastatic triple negative breast cancer.
Monoclonal Antibodies
Boserolimab + Pembrolizumab + Pemetrexed + Carboplatin + Nab-paclitaxel for Solid Tumors
This trial will assess the safety and how the body processes MK-5890 when given alone or with pembrolizumab over the course of 35 administrations. Additionally, the trial will assess the safety of MK-5890 when given with pemetrexed and carboplatin to adults with nonsquamous non-small cell lung cancer or with nab-paclitaxel to adults with triple-negative breast cancer.
PD-L1 Positive Clinical Trials
View 19 PD-L1 positive medical studies.
Monoclonal Antibodies
Combination Therapy for Metastatic Triple Negative Breast Cancer
This trial will test the effectiveness of durvalumab, a new immunotherapy drug, in combination with other cancer treatments, for people with first-line metastatic triple negative breast cancer.
Monoclonal Antibodies
Boserolimab + Pembrolizumab + Pemetrexed + Carboplatin + Nab-paclitaxel for Solid Tumors
This trial will assess the safety and how the body processes MK-5890 when given alone or with pembrolizumab over the course of 35 administrations. Additionally, the trial will assess the safety of MK-5890 when given with pemetrexed and carboplatin to adults with nonsquamous non-small cell lung cancer or with nab-paclitaxel to adults with triple-negative breast cancer.
PD-1 Positive Clinical Trials
View 13 PD-1 positive medical studies.
Monoclonal Antibodies
Boserolimab + Pembrolizumab + Pemetrexed + Carboplatin + Nab-paclitaxel for Solid Tumors
This trial will assess the safety and how the body processes MK-5890 when given alone or with pembrolizumab over the course of 35 administrations. Additionally, the trial will assess the safety of MK-5890 when given with pemetrexed and carboplatin to adults with nonsquamous non-small cell lung cancer or with nab-paclitaxel to adults with triple-negative breast cancer.
Monoclonal Antibodies
Pembrolizumab + Chemotherapy for Breast Cancer
This trial will study the safety of giving pembrolizumab with either paclitaxel or capecitabine to people with triple negative breast cancer that has spread and cannot be removed by surgery.
Monoclonal Antibodies
Pembrolizumab for Solid Tumors
This trial will study the changes in genes and immune cells of patients with solid tumors before and during treatment with pembrolizumab to see if there is a correlation with how well the patients respond to the treatment.
Triple Negative Breast Cancer Clinical Trials With No Placebo
View 98 triple negative breast cancer medical studies that do not have a placebo group.
PARP Inhibitor
Olaparib + Pembrolizumab for Triple Negative Breast Cancer
This trial is comparing the efficacy of two different treatments for triple negative breast cancer - olaparib plus pembrolizumab versus chemotherapy plus pembrolizumab. The primary hypotheses are that olaparib plus pembrolizumab will be superior to chemotherapy plus pembrolizumab in terms of progression-free survival and overall survival.
View More Triple Negative Breast Cancer Trials
See another 74 many medical studies focused on triple negative breast cancer.
Frequently Asked Questions
Introduction to triple negative breast cancer
What are the top hospitals conducting triple negative breast cancer research?
When it comes to clinical trials dedicated to tackling the formidable challenge of triple negative breast cancer, several hospitals have emerged as leaders in this field. In Boston, Massachusetts General Hospital is at the forefront with nine active trials focused on triple negative breast cancer, Massachusetts General Hospital is at the forefront with nine active trials focused on triple negative breast cancer and a total of 34 completed studies in this area. Their commitment dates back to 2011 when they initiated their first recorded trial for this specific type of breast cancer. Not far behind, the Dana-Farber Cancer Institute also located in Boston, is making significant strides with eight ongoing clinical trials and an impressive history of 33 previous trials since their inaugural study in 2010 that addressed triple negative breast cancer.
Meanwhile, Memorial Sloan Kettering Cancer Center situated in New York City has established itself as another prominent institution actively engaged in combating triple negative breast cancer. With seven ongoing trials and a remarkable record of 38 completed studies over time since their initial investigation began in 2011 specifically targeting this aggressive form of breast cancer; here too great dedication can be seen towards finding new treatments.
Further down south, MD Anderson Cancer Center based out Houston plays its part by conducting six current clinical tests while having accumulated notable expertise through fourteen previous experiments after launching its first recorded trial centered around triple-negative tumors just a decade ago from now- i.e.,inthe year2012.And finally highlighting Beth Israel Deaconess Medical Center which stands alongside MD Anderson by also contributing six ongoing investigations into developing breakthroughs againsttriple-negativebreastcancer.NotwithstandingbeingrelativelynewerinthefieldtheyalongsidehaveachievedeighteencompletedclinicalstudieswhichstartedwaybacktowardsthoseearlyyearsfromtheirfirsttrialinitiatedinthesimilarlyyearasDanaFarbersonei.e.,during theyearof2010.
With these esteemed institutions leading the charge against triple negative breast cancer through cutting-edge research and innovative clinical trials,tremendoushopeandpotentialforadvancementarebroughttothe table. The collaborative efforts of these top hospitals demonstrate a unified commitment to finding treatments and improving outcomes for those affected by this challenging form of breast cancer.
Which are the best cities for triple negative breast cancer clinical trials?
When it comes to clinical trials for triple negative breast cancer, several cities emerge as top contenders. Boston, Massachusetts leads the pack with 44 active trials investigating Pembrolizumab, Atezolizumab, Cediranib Maleate, and other promising treatments. Houston, Texas closely follows with 40 ongoing studies centered around Pembrolizumab and innovative approaches for tumors larger than 5 cm. New York City also boasts 40 active trials focusing on BMS-986340, Pembrolizumab, Carboplatin, and other potential breakthroughs. Nashville, Tennessee and Chicago, Illinois round out the list with their respective contributions of 33 and 27 active trials exploring Enzalutamide, DF6002,TAK-676,and more. These cities offer hope to individuals battling triple negative breast cancer, Massachusetts leads the pack with 44 active trials investigating Pembrolizumab, Atezolizumab, Cediranib Maleate, and other promising treatments. Houston, Texas closely follows with 40 ongoing studies centered around Pembrolizumab and innovative approaches for tumors larger than 5 cm. New York City also boasts 40 active trials focusing on BMS-986340, Pembrolizumab, Carboplatin, and other potential breakthroughs. Nashville, Tennessee and Chicago, Illinois round out the list with their respective contributions of 33 and 27 active trials exploring Enzalutamide, DF6002,TAK-676,and more. These cities offer hope to individuals battling triple negative breast cancer through cutting-edge research that may lead to improved treatment options in the future.
Which are the top treatments for triple negative breast cancer being explored in clinical trials?
In the realm of clinical trials, several treatments are currently under exploration for triple negative breast cancer. Taking the lead is pembrolizumab, impressively involved in 17 active trials and boasting a total of 82 all-time studies dedicated to this aggressive subtype since its introduction in 2015. Atezolizumab follows closely behind with four ongoing trials and a history of 27 all-time triple negative breast cancer studies since its debut in 2015. Additionally, enzalutamide has shown promise, participating in two active trials and totaling five all-time triple negative breast cancer trials since being listed in 2013. On the horizon are newer contenders NUV-868 and SGN-B7H4V, each making their mark with one active trial and one all-time trial respectively after being introduced just last year (2022). As research progresses tirelessly, these potential breakthroughs offer hope for improved treatment options against this challenging form of breast cancer.
What are the most recent clinical trials for triple negative breast cancer?
Recent clinical trials have brought forth promising advancements in the field of triple negative breast cancer, offering new possibilities for treatment. One notable study focuses on tumors larger than 5 cm and aims to enhance therapeutic outcomes in this specific subgroup. Another trial explores the potential benefits of an Anti-HER2/HER3 Dendritic Cell Vaccine, which holds promise as a targeted approach against triple negative breast cancerl Vaccine, which holds promise as a targeted approach against triple negative breast cancer. Additionally, researchers are investigating the efficacy and safety profile of SGN-PDL1V and NUV-868 for this aggressive form of breast cancer. These trials mark significant progress in our understanding and management of triple negative breast cancer, providing hope for improved patient outcomes in the future.
What triple negative breast cancer clinical trials were recently completed?
Recent clinical trials have made significant progress in the search for effective treatments for triple negative breast cancer. G1 Therapeutics, Inc.'s trial on Trilaciclib was completed in November 2021, showing promising results. In October 2020, VelosBio Inc. concluded their study on Zilovertamab vedotin, which holds potential as a treatment option. Another notable trial was conducted by Hoffmann-La Roche and focused on Tiragolumab; it reached completion in September 2020. These advancements bring hope to those affected by triple negative breast cancer and highlight the ongoing commitment of researchers to find new breakthroughs that could improve patient outcomes.