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mRNA-2752 + Durvalumab for Advanced Cancers
Study Summary
This trial will test how well a new drug works in people with cancer that has returned or does not respond to treatment.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2022 Phase 3 trial • 867 Patients • NCT03084471Trial Design
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Who is running the clinical trial?
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- My thyroid function is normal, or I have stable hypothyroidism with proper treatment.I have not had radiotherapy or cancer treatment in the last 14 days.I do not have an active infection like TB, hepatitis B, hepatitis C, or HIV.I do not have any serious ongoing illnesses that would affect my participation in the study.I have used immunosuppressive medication within the last 14 days.I weigh more than 30 kilograms.I have or had an autoimmune or inflammatory disorder.I can and am willing to provide tumor samples for biopsy if it's safe.I am on blood thinners and will be during my tumor injection or biopsy.I have a lasting side effect that won't worsen with durvalumab, confirmed by a medical expert.My advanced cancer has at least one tumor that can be measured.I have active bleeding in my GI tract or lungs, or a history of bleeding disorders.I have moderate to severe nerve pain or damage.You have a history of a weak immune system, receiving an organ transplant from someone else, or having had tuberculosis.I have not received a live vaccine in the last 30 days.I haven't had major surgery in the last 28 days or minor surgery in the last 7 days.I have active brain tumors or cancer that has spread to my brain.I haven't had cancer treatment or investigational drugs within the last 28 days or 5 half-lives, whichever is shorter.I don't have lasting side effects from cancer treatment, except for hair loss or skin changes.I am not pregnant, breastfeeding, and willing to use birth control during and up to 120 days after the study.I am post-menopausal or not pregnant if pre-menopausal.My blood and organ functions are within normal ranges.I can carry out all my self-care activities and haven't gotten worse in the past 2 weeks.My cancer has worsened despite treatment, or I cannot tolerate/choose not to have standard treatment.
- Group 1: Arm A: mRNA-2752
- Group 2: Arm C: mRNA-2752 Alone or mRNA-2752 + Durvalumab
- Group 3: Arm B: mRNA-2752 + Durvalumab
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has the FDA given their blessing to mRNA-2752?
"So far, mRNA-2752 has only been minimally tested for safety and efficacy, thus earning a score of 1."
What illnesses does mRNA-2752 typically target?
"mRNA-2752 is widely employed to treat unresectable stage III non-small cell lung cancer, as well as previously untreated metastatic urothelial carcinoma and advanced directives."
Are there any locales currently administering this research project within city boundaries?
"The Sarah Cannon Research Institute in Nashville, the UCSF Helen Diller Family Comprehensive Cancer Center in San Francisco, and Yale Cancer Center in New Haven are some of the 15 active sites for this study. Other locations also exist which qualify for enrolment."
What is the scope of participants in this clinical exploration?
"AstraZeneca, the sponsor of this trial, needs to recruit 264 candidates that meet their set inclusion criteria. These patients will be sourced from multiple medical centres including Sarah Cannon Research Institute in Nashville and UCSF Helen Diller Family Comprehensive Cancer Center located in San Francisco."
Are there any vacancies available for individuals to partake in this research?
"Affirmative. Clinicaltrials.gov states that, as of July 14th 2022, this research is actively enrolling 264 patients across 15 medical facilities. The trial was initially posted on November 27th 2018 and has been modified since then."
Are there any prior investigations involving mRNA-2752 that have been documented?
"Currently, 333 clinical trials are underway studying the effects of mRNA-2752 with 52 studies at Phase 3. Most locations for these trials are located in Cordoba, Texas; however, this medication is being trialed across 12961 centers globally."
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