Resveratrol for Coronary Artery Disease
(SIRT-CVS Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. However, since the trial includes patients with type 2 diabetes controlled by oral agents or insulin, it seems likely that you can continue those medications.
What data supports the effectiveness of the drug resveratrol for coronary artery disease?
Research suggests that resveratrol, a compound found in grapes and red wine, may protect the heart by improving blood flow and reducing heart damage in animal models. It has shown potential benefits in preventing heart problems and improving heart health in humans, although more research is needed to confirm its effectiveness for coronary artery disease specifically.12345
Is resveratrol safe for human use?
How does the drug trans-resveratrol differ from other treatments for coronary artery disease?
Trans-resveratrol is unique because it is a natural compound found in red wine and other plants, known for its antioxidant and anti-inflammatory properties. Unlike traditional treatments, it may improve heart health by protecting against oxidative stress and enhancing blood flow in the heart, potentially offering a novel approach to managing coronary artery disease.246910
What is the purpose of this trial?
Major ProblemPeople with diabetes have an increased risk of heart disease, heart failure, and death from a cardiovascular cause. Diabetes prevents efficient metabolism of fuel, causes inflammation and vascular disease that blocks normal blood flow, and inhibits the function of the heart after injury. These changes make diabetics more susceptible to heart attacks and heart failure.Resveratrol is found in grapes and red wine and has been shown to have beneficial effects in diabetic patients. In previous studies the investigators have shown that resveratrol can improve heart metabolism and function in pigs with diabetes and chronic lack of blood flow to the heart.QuestionsThe investigators believe resveratrol will help reverse the negative effects of diabetes on the heart. The questions are: 1.How does the molecular machinery in the hearts of patients with diabetes differ from patients without diabetes? 2.Will resveratrol have an effect on heart metabolism, intracellular signaling, inflammation and blood vessel function? 3.Will resveratrol improve the number and function of cardiac stem cells, cells involved in heart repair? The investigators have been safely collecting tissue from the hearts of patients undergoing heart surgery. Preliminary studies show the investigators can isolate and study cells. The investigators have collected and assessed the function of endothelial cells, a measure of vascular health and can measure the level of endothelial injury and have studied the make-up of caveolae, structures on the cell membrane that are important for cell signaling and are negatively impacted by diabetes. This study is a unique collaboration among cardiologists, cardiac surgeons, and basic scientists.
Research Team
Douglas Sawyer
Principal Investigator
Maine Health
Eligibility Criteria
Adults over 18 with Type 2 diabetes and coronary artery disease scheduled for elective heart bypass surgery can join. They must not have severe kidney, liver, or blood clotting issues, be pregnant, or have certain infections like HIV. Heavy drinkers and those unlikely to follow the study plan are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive resveratrol or placebo during coronary artery bypass grafting with cardiopulmonary bypass
Follow-up
Participants are monitored for changes in endothelial function and molecular signaling
Treatment Details
Interventions
- Placebo
- Trans-resveratrol
Find a Clinic Near You
Who Is Running the Clinical Trial?
MaineHealth
Lead Sponsor
American Heart Association
Collaborator