CLINICAL TRIAL

Trans-resveratrol for Diabetes Mellitus, Type 2

Recruiting · 18+ · All Sexes · Portland, ME

Short Interval Resveratrol Trial in Cardiovascular Surgery

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About the trial for Diabetes Mellitus, Type 2

Eligible Conditions
Coronary Artery Disease · Diabetes Mellitus, Type 2

Treatment Groups

This trial involves 2 different treatments. Trans-resveratrol is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Trans-resveratrol
DIETARYSUPPLEMENT
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Placebo
DIETARYSUPPLEMENT

About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Trans-resveratrol
2012
Completed Phase 1
~80

Eligibility

This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Coronary artery disease that is being referred for an elective surgery to remove plaque from the arteries using a heart-lung machine. show original
The text is about adult patients. show original
is prevalent in overweight patients and is often associated with obesity show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 14 days
Screening: ~3 weeks
Treatment: Varies
Reporting: 14 days
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 14 days.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Trans-resveratrol will improve 1 primary outcome and 2 secondary outcomes in patients with Diabetes Mellitus, Type 2. Measurement will happen over the course of 14 days.

Effects of resveratrol on molecular signaling
14 DAYS
Serum and tissue levels of pathways associated with glucose metabolism (Western blot assay)
14 DAYS
Effects of resveratrol on caveolar function
14 DAYS
Lipidomic changes in cell membranes (Mass spectrometry)
14 DAYS
Change in endothelial function
14 DAYS
Nitric oxide synthase levels in heart tissue (Western blot assay)
14 DAYS

Who is running the study

Principal Investigator
D. B. S.
Douglas B. Sawyer, Chief Academic Officer
MaineHealth

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has trans-resveratrol proven to be more effective than a placebo?

The study demonstrates that trans-resveratrol can safely relieve the symptoms of diabetic peripheral neuropathy and has antihyperalgesic and antiinflammatory potentials. The treatment of diabetes and complications like diabetic neuropathy is a growing research area.

Anonymous Patient Answer

What causes diabetes mellitus, type 2?

Diabetes mellitus, type 2 is caused by a combination of environment and genetics. In most cases it is diagnosed before the age of 20 years old or has its origins in childhood but can be diagnosed after an age of 65 years.

Anonymous Patient Answer

What are the signs of diabetes mellitus, type 2?

Diabetes mellitus type 2 causes many signs and symptoms. A person is considered to have diabetes mellitus type 2 if they have elevated blood glucose levels even while fasting, have it acutely in the presence of diabetes mellitus type 1 or 2 or if it is more than 2 h plasma or serum glucose in 100 mL of blood, at or above 14.0 mg/dl at any time in the preceding 2 hours. Diabetes is common enough to warrant screening for it at the level of a primary care physician. Diabetes in a person that has recently developed diabetes should lead to the evaluation for other signs of disease.

Anonymous Patient Answer

Can diabetes mellitus, type 2 be cured?

Diabetes cannot be cured. However, excellent glucose control can have huge benefits. In recent years, new treatment options and improved understanding of its complexities have advanced this goal dramatically. Diabetes can be a treatable disorder; but a cure is elusive right now.

Anonymous Patient Answer

Is trans-resveratrol safe for people?

Dietary supplementation with trans-resveratrol showed no adverse events or serious harm in healthy subjects across the dose range of 100-200 mg per day. Although further clinical studies are needed to confirm these results, trans-resveratrol appears to be safe for healthy people across the dose range tested.

Anonymous Patient Answer

What is diabetes mellitus, type 2?

Diabetes mellitus, type 2 is marked by elevated levels of blood sugar over months or years. Diabetes mellitus type 2 can cause many long term complications, including blindness, kidney disease and cardiovascular disease. The annual number of new cases of diabetes mellitus type 2 is expected to rise, and the severity of the disease may cause a sharp increase in healthcare spending to control the disease.

Anonymous Patient Answer

How many people get diabetes mellitus, type 2 a year in the United States?

For a given duration of the year, the projected number of new patients with diabetes mellitus, type 2 in the US exceeds the estimated number of patients with type 2 diabetes reported in the literature. There is disagreement in the literature about the prevalence of diabetes mellitus, type 2. If data from all continents can be combined, there may be some international agreement on the prevalence of diabetes mellitus, type 2, but given some of the variability in individual studies, there is no reason to believe that the data will be consistent.

Anonymous Patient Answer

What are common treatments for diabetes mellitus, type 2?

Diabetes mellitus, type 2 is typically treated with a combination of dietary modification, medication, exercise, and weight loss. The primary goals of treatment are prevention of complications and maintenance of optimal glucose levels. Complications of diabetes mellitus, type 2 include cardiovascular disease, blindness, stroke, and diabetic ketoacidosis. Diabetes mellitus, type 2 can be treated with various medications, including insulin, metformin, oral hypoglycemic medications, thiazine diuretics, or a combination thereof.

Anonymous Patient Answer

Have there been other clinical trials involving trans-resveratrol?

The clinical trial is the first reported using trans-resveratrol with regard to the treatment of diabetes. It is also the first reported with regard to the treatment of diabetes mellitus type 2 [power]. Results from a recent paper suggest that this is feasible and safe.

Anonymous Patient Answer

How serious can diabetes mellitus, type 2 be?

Diabetes may be a leading cause of death in the USA, with high-risk populations including men, nonwhite persons, and the non-poor. If confirmed in other studies, this would warrant increased screening and timely and appropriate intervention as a health problem and a public health concern.

Anonymous Patient Answer

How does trans-resveratrol work?

Results from a recent paper, trans-resveratrol decreased blood glucose levels in T1DM and T2DM patients. In the current study, the use of trans-resveratrol was associated with improvement in endothelial function and a decrease in c-fos level, suggesting its potential to improve glucose tolerance. Therefore, trans-resveratrol has the potential to be used to increase insulin sensitivity in insulin-resistant T2DM patients who are at high risk of diabetic complications. In addition, future studies investigating the mechanistic pathways underpinning such mechanisms are warranted.

Anonymous Patient Answer

What are the common side effects of trans-resveratrol?

There was a large range of common side effects, including dizziness, and the most common side effect was a dry mouth. The number of people affected by a dry mouth in our sample was more than double the number of people affected by low fasting blood sugar when used at 10mg/day. Based on our findings, we think that trans-resveratrol would be well suited as a natural treatment for type 2 diabetes.

Anonymous Patient Answer
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