Resveratrol for Type 1 Diabetes
(T-St1M Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using vasoactive medications (drugs that affect blood vessel function).
Is resveratrol safe for humans?
How does the drug resveratrol differ from other treatments for type 1 diabetes?
Resveratrol is a natural compound found in foods like grapes and wine, and it may help improve blood sugar control and insulin activity in type 1 diabetes. Unlike standard insulin therapy, resveratrol also has antioxidant and anti-inflammatory properties, which could provide additional health benefits.35678
What evidence supports the effectiveness of resveratrol as a treatment for type 1 diabetes?
Research shows that resveratrol, a compound found in red wine and other foods, can help protect against diabetes in animal studies by lowering blood sugar levels and improving insulin function. It has also been shown to improve blood sugar control in diabetic rats, suggesting potential benefits for type 1 diabetes.356910
Are You a Good Fit for This Trial?
This trial is for men and premenopausal women of all races with a clinical diagnosis of insulin-dependent type 1 diabetes. Participants should not be pregnant, have uncontrolled diabetes (HbA1C >12%), diabetic complications like neuropathy, or diagnosed liver, heart, or kidney diseases. They also shouldn't have high blood pressure (>140/90 mm Hg on therapy) or be taking vasoactive medications.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive resveratrol or placebo for 12 weeks to assess ETBR and skeletal muscle mitochondrial function
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Placebo
- Resveratrol
Find a Clinic Near You
Who Is Running the Clinical Trial?
Augusta University
Lead Sponsor