Cardiovascular exercise for Insulin Resistance
This study is evaluating whether exercise training may help improve insulin resistance and muscle perfusion in individuals with type 2 diabetes.
See full descriptionAbout the trial for Insulin Resistance
Treatment Groups
This trial involves 2 different treatments. Cardiovascular Exercise is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
Eligibility
This trial is for patients born any sex between 18 and 65 years old. There are 3 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Cardiovascular exercise will improve 2 primary outcomes in patients with Insulin Resistance. Measurement will happen over the course of Through study completion, approximately 4 months.
Patient Q & A Section
How many people get insulin resistance a year in the United States?
There is a substantial percentage of Americans who get insulin resistance and more that 100 million Americans were at risk for prediabetes. Efforts to combat the metabolic syndrome could not only halt future heart disease but may also substantially reduce future diabetes onset.
What causes insulin resistance?
It is known that increased insulin levels will increase muscle proteins, an effect that may be offset by increased protein breakdown, explaining why skeletal muscle strength is increased. However, the present results show that insulin is also needed to increase adipose tissue growth and increase blood glucose levels, explaining why some types of skeletal muscle may be reduced in patients with IR (with respect to normal-weight people). Finally, increased muscle strength and decreased adiposity may be caused by the same mechanisms of insulin. Together, these results indicate that muscle strength could be a potential factor involved in the development of IR.
What are the signs of insulin resistance?
The presence of lipodystrophy is the defining sign of insulin resistance. However, the symptoms of insulin resistance are multidentified and include central obesity, hypertension, insulin resistance, lipid disorders and elevated insulin.
Can insulin resistance be cured?
The data indicate that metabolic and other variables related to insulin resistance cannot be corrected by lifestyle modifications but that one or more of the variables may be corrected.
What are common treatments for insulin resistance?
Some common treatments for insulin-resistant adults with the metabolic syndrome include diet interventions (including exercise) and the use of metformin. Other treatments commonly used include behavioral approaches for weight loss, such as dieting and exercise, exercise and/or weight loss programs, prescription medications such as orlistat, and insulin regimens such as metformin, as well as the administration of agents for type 2 diabetes.
What is insulin resistance?
Insulin resistance is present more commonly in non-diabetic individuals that are overweight, particularly African-Americans, than in those who are of the leaner body-mass type. In individuals with insulin resistance, hyperinsulinemia may contribute to the development of insulin resistance with a resultant adverse effect on glucose tolerance and insulin action thereby contributing to weight gain.
Does insulin resistance run in families?
We found no evidence for the inheritance of IR in this cohort. We found no evidence that IR is inherited more often than would be expected if it were randomly distributed. Therefore, if IR is not inherited the cause of obesity, it must occur coincidentally that IR is not inherited. The absence of a consistent finding to date does not mean that IR is not genetically controlled.
What does cardiovascular exercise usually treat?
Exercise appears to benefit cardiovascular and metabolic traits in children, adolescents and adults that need it. Benefits are likely to be greater and longer lasting in children when aerobic exercise is combined with other beneficial physical activity. Longitudinal studies for at least five years are required to clarify the long-term effects of exercise on cardiovascular risk factors.
How does cardiovascular exercise work?
The study indicates that cardiovascular exercise is able to increase skeletal muscle mitochondrial uncoupling protein 2 expression. There was not any difference in mitochondrial protein expression or oxidative capacity in cardiac protein between exercise groups in a control regimen.
What is the average age someone gets insulin resistance?
The average age at insulin resistance detection in both sexes is 39 years. It is not uncommon for type 2 diabetes to occur even with low-normal serum glucose levels in the middle and late third decade of life, an observation that may also suggest that the age at diagnosis is not a reliable indicator of the duration of the disease.
What is the latest research for insulin resistance?
While there have been many changes in what we know about insulin resistance, recent research has proven that there is no good replacement drug yet. For anyone who is looking to stop blood sugar levels from being too high at the beginning of insulin therapy, it's helpful to consider insulin-sensitizing tablets.
Have there been any new discoveries for treating insulin resistance?
There are many different new drugs being researched for insulin's inability to treat [type 2 diabetes](https://www.withpower.com/clinical-trials/type-2-diabetes) in children and adults who may also have insulin resistance. While one drug is able to treat insulin resistance, it does not treat its cause, type 2 diabetes (as found in the NIH's National Center for Diabetes and Digestive and Kidney Disease). More research is being done to discover drugs with different mechanisms and new compounds. Drugs in development are being assessed first in cell culture to see if they cause insulin resistance when taken by patients in which type 2 diabetes comes from them. At this point, only seven compounds are being explored. None of them are being recommended to be marketed to patients until they are shown to be safe and effective in people with type 2 diabetes.