Cardiovascular Exercise for Type 2 Diabetes
(REACH Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial requires that participants do not take certain medications, including beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD). If you are on these medications, you may need to stop taking them to participate.
What data supports the effectiveness of the treatment Cardiovascular Exercise for Type 2 Diabetes?
Is cardiovascular exercise safe for people with type 2 diabetes?
How does cardiovascular exercise differ from other treatments for type 2 diabetes?
Cardiovascular exercise is unique because it is a non-drug treatment that improves insulin sensitivity and reduces cardiovascular risk factors, such as high blood pressure and cholesterol, through regular physical activity. Unlike medications, it also helps with weight management and overall fitness, making it a holistic approach to managing type 2 diabetes.1791011
What is the purpose of this trial?
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.
Eligibility Criteria
This trial is for sedentary adults with a BMI of 25-40, who may or may not have type 2 diabetes. It's not suitable for those with uncontrolled high blood pressure, taking certain heart and diabetes medications, smokers, or people with cardiovascular disease, lung conditions like asthma, severe nerve damage in limbs (peripheral neuropathy), anemia, liver or kidney disease.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo exercise training to assess its impact on insulin resistance and muscle perfusion
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Cardiovascular exercise
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Colorado, Denver
Lead Sponsor
University of Virginia
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator