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rTMS for Bipolar Disorder
Study Summary
This trial is being conducted to test the effects of high-dose, spaced theta-burst transcranial magnetic stimulation (TMS) on depressive symptoms in patients with bipolar disorder (BPD) who have failed to respond to prior treatments. The null hypothesis is that there will be no difference in reductions in depressive symptoms between the active TMS group and the sham group. The alternative hypothesis is that, compared with sham, active TMS will result in a greater reduction in depressive symptoms. The study will also aim to identify biomarkers in cortical regions associated with BPD and to formulate a statistical model that may be able to predict BPD remission after
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check βYesβ for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am between 18 and 70 years old.I do not have a severe illness like widespread cancer or kidney failure.I have depression that hasn't improved after trying at least two different antidepressants.I have been diagnosed with bipolar depression.I am on a consistent medication plan that includes at least one mood stabilizer.My depression is severe, scoring 20 or more on MADRS.My depression is severe, scoring 20 or more on a scale.I do not have depression as my main health issue.I don't have implants or conditions that make TMS or MRI unsafe for me.My gender does not affect my eligibility.I have been diagnosed with bipolar depression.I have depression that hasn't improved after trying at least 2 different antidepressants.I am between 18 and 70 years old.You must specify which hand you use β right or left.My gender does not affect my eligibility.You are able to provide informed consent to participate in the study.I am on a consistent medication plan that includes at least one mood stabilizer.
- Group 1: Sham iTBS
- Group 2: Active iTBS
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
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What portion of applicants met pre-screening criteria?
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How responsive is this trial?
Typically responds via
Most responsive sites:
- UCSD Interventional Psychiatry: < 48 hours
Average response time
- < 2 Days
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