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Atezolizumab + Bevacizumab for Advanced Head and Neck Cancer
Study Summary
This trial is comparing standard therapy (chemotherapy plus cetuximab) to adding bevacizumab to standard chemotherapy, versus a combination of just bevacizumab and atezolizumab in treating patients with head and neck cancer that has spread to other places in the body (metastatic or advanced stage) or has come back after prior treatment (recurrent).
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2012 Phase 3 trial • 73 Patients • NCT01177956Trial Design
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Who is running the clinical trial?
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- Group 1: Phase II, Arm C (Bevacizumab, Atezolizumab)
- Group 2: Phase II, Arm B(Docetaxel, Cisplatin/Carboplatin, Bevacizumab)
- Group 3: Phase III, Arm B (Chemotherapy, Bevacizumab, Atezolizumab)
- Group 4: Phase II, Arm A (Cetuximab, Docetaxel, Cisplatin, Carboplatin)
- Group 5: Phase III, Arm A (Cetuximab, Docetaxel, Cisplatin/Carboplatin)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are some indications for which Cetuximab is indicated?
"Cetuximab is frequently used to treat non-hodgkin lymphoma but can also be useful in treating metastatic bladder cancer, initial treatment, and recurrent cervical cancer."
What are some other clinical trials that have utilized Cetuximab?
"Cetuximab was first studied in 1997. In the 24 years since its inception, there have been 3468 completed trials worldwide. Right now, 2060 different cetuximab trials are actively recruiting patients; many of these studies are based out of Dayton, Florida."
Where can patients sign up for this clinical trial?
"Presently, this study is being conducted in 85 different locations, which include but are not limited to Dayton, Fort Lauderdale and Des Moines. It would be most convenient for you to select the site nearest your location to minimize travel requirements."
Are we still recruiting people to participate in this research?
"Yes, this clinical trial is recruiting patients as indicated by the most recent updates on clinicaltrials.gov. The study was originally posted on December 16th, 2021 and last updated November 12th, 2022. They are looking for 430 individuals to participate across 85 different locations."
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