VX-880 for Diabetes, Autoimmune
This study is evaluating whether a drug may help individuals with type 1 diabetes mellitus.
See full descriptionAbout the trial for Diabetes, Autoimmune
Treatment Groups
This trial involves 2 different treatments. VX-880 is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
Eligibility
This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether VX-880 will improve 2 primary outcomes and 2 secondary outcomes in patients with Diabetes, Autoimmune. Measurement will happen over the course of At 1 year after VX-880 infusion.
Patient Q & A Section
What are the signs of diabetes, autoimmune?
Signs of diabetes and/or autoimmunity may include persistent excessive thirst or not feeling thirsty, frequent urination, increased urination, dark urine, blurred vision, dry mouth, loss of weight, abdominal or back pain, and loss of appetite. Often the symptoms are similar to symptoms of other illnesses, leading to long-term illness.\n
Can diabetes, autoimmune be cured?
Although, the precise mechanism of islets destruction at a cellular level, autoimmunity has been demonstrated as very important role in the pathogenesis of diabetes. There is a lot of evidence to support that autoimmune process can be cured in human. Diabetes, auto-immune could be cured just by proper therapy in the right period of time. For the patients have diabetes over the age of 60 years, autoimmune process can be cured too. Patients with diabetes, who are in pain, but do not have any symptom, could be cured immediately through proper therapy.
What causes diabetes, autoimmune?
There appears to be a genetic component to diabetes, and one that has also been linked with autoimmune conditions such as multiple sclerosis, rheumatoid arthritis and type 1 diabetes.
How many people get diabetes, autoimmune a year in the United States?
As of 2012, 9.7 million people, or 10.6 % of the U.S. population, had type 1 diabetes. Among the 2.2 million people with type 2 diabetes, 1.2 million (64% of these patients) had an autoimmune diagnosis. As a whole, there were nearly 9.9 million people with an autoimmune diagnosis in the U.S, including 3.6 million with type 1 diabetes.
What is diabetes, autoimmune?
In an adult, non-obese man with diabetes, the presence of autoimmune dysfunction as determined by increased body mass index, diabetes duration, abnormal\nglycemic control, or use of immunosuppressive medications is uncommon.
What are common treatments for diabetes, autoimmune?
Diabetics are frequently treated with insulin for type 1 diabetes, and many also have other autoimmunity. Treatment may include lifestyle adjustments, diet, regular physical activity, and medications for high blood pressure, diabetic foot, hypercholesterolemia, and blood pressure. Treatment for autoimmune diseases can include antispasmodic and/or anticholinergic medications. Immunosuppressants can be prescribed for autoimmune diseases, particularly for steroid-refractory disease.
Does vx-880 improve quality of life for those with diabetes, autoimmune?
Treatment with VX-880 substantially improved quality of life, including symptoms of depression, anxiety, and fatigue, as measured by the WHOQOL in patients with early-stage NIPA at the time of initiating VX-880. Results from a recent clinical trial confirm the efficacy of VX-880 in patients with NIPA and identify new improvements in quality of life with treatment.
Who should consider clinical trials for diabetes, autoimmune?
At present, clinical trials are being limited mainly to diabetes. As a result, only a small proportion of trials and patients is involved in assessing the effect of a new diabetes treatments. Clinical trials of alternative treatments for autoimmune disease must be developed to offer new treatments to patients for whom existing therapies do not offer long term control of disease symptoms.
Is vx-880 safe for people?
Vx-880 is a potentially useful agent for treating rheumatoid arthritis and psoriasis but does appear to have a potential adverse effect profile which may require special consideration before starting it. It is also unclear whether it is safe at the lower doses used in psoriasis.
Have there been other clinical trials involving vx-880?
So far, vx-880 hasn't been shown to be an effective agent for treatment of any autoimmune disorder like insulin-dependent diabetes. Moreover, there isn't much research on vx-880 so we don't have much definitive answer as to whether or not it is effective to treat autoimmune disorders like diabetes.
How does vx-880 work?
Results from a recent paper showed that the anti-cancer effects of VX-880 in MCF-7 cell lines can be attributed to a number of possible mechanisms like caspase-dependent apoptosis, cell cycle regulation and induction of antioxidant pathways.
Have there been any new discoveries for treating diabetes, autoimmune?
The discovery of new drugs to treat [severe non-obese type 2 diabetes mellitus] and/or autoimmune disorders will [be very difficult] to achieve in the near future as it takes several years (up to 10 years) before a drug is available that meets the standards of a "gold-standard" treatment.