Study Summary
This trial will study if VX-880 is safe and effective in people with Type 1 diabetes who have impaired awareness of low blood sugar and have had severe hypoglycemia.
- Type 1 Diabetes
- Low Blood Sugar
- Hypoglycemia Unawareness Syndrome
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
2 Primary · 2 Secondary · Reporting Duration: From VX-880 infusion to end of study (up to 5 years)
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
1 Treatment Group
VX-880
1 of 1
Experimental Treatment
17 Total Participants · 1 Treatment Group
Primary Treatment: VX-880 · No Placebo Group · Phase 1 & 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18 - 65 · All Participants · 1 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
| New York | 33.3% |
| North Carolina | 16.7% |
| Pennsylvania | 16.7% |
| Other | 33.3% |
How old are they?
| 18 - 65 | 100.0% |
What portion of applicants met pre-screening criteria?
| Did not meet criteria | 50.0% |
| Met criteria | 50.0% |
What site did they apply to?
| University of Chicago | 25.0% |
| Hospital of the University of Pennsylvania | 25.0% |
| University of Pittsburgh Medical Center Montefiore | 25.0% |
| Other | 25.0% |
Why did patients apply to this trial?
- "I want to help because I hate having diabetes"
How many prior treatments have patients received?
| 3+ | 100.0% |
How responsive is this trial?
Typically responds via
| Phone Call | 50.0% |
| 50.0% | |
Most responsive sites:
- VCU Medical Center, Richmond: < 24 hours
Average response time
- < 1 Day
Frequently Asked Questions
In how many different medical clinics is this research study being conducted today?
"So far, 11 locations have recruited patients for this trial. For example, there are participants from Massachusetts General Hospital in Boston, University of Wisconsin in Madison, and Hospital of the University of Pennsylvania in Philadelphia." - Anonymous Online Contributor
Can people with the specified condition still sign up for this trial?
"Yes, the clinical trial is still recruiting patients. According to information on clinicaltrials.gov, the trial was first posted on 3/29/2021 and was last edited on 8/8/2022. So far, 17 participants have been recruited from 11 different sites." - Anonymous Online Contributor
Does this study have an age requirement?
"The current enrolment phase for this clinical trial includes people aged 18-65." - Anonymous Online Contributor
How many participants are being recruited for this research?
"As specified by the sponsor, Vertex Pharmaceuticals Incorporated, a total of 17 patients that meet this trial's inclusion criteria are required in order to run the study from various locations - such as Massachusetts General Hospital in Boston, Wisconsin and University of Wisconsin in Madison, Pennsylvania." - Anonymous Online Contributor