3D Knee Kinematics Assessment for Understanding Knee Movement

Overseen By Fidaa Al-Shakfa, MSc

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Disqualifiers: Active infection, Severe swelling, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

10 Participants Needed

Trial Summary

What is the purpose of this trial?

Problem : Precise and personalized 3D knee kinematic assessment during physical and daily life activities is a challenge; therefore, it was never performed on an important number of individuals. However, a better understanding of 3D knee kinematics during such activities would allow a better understanding of this often injured joint. Hypothesis: A new system using personalized 3D bone imaging and a percutaneous bone fixation device that can be used under local anesthesiaallows for precise and reproducible assessment of 3D knee kinematics during physical and daily life activities. Objectives : * To study human knee 3D kinematics during dynamic activities using a novel minimally invasive measuring system * Investigate the correlations between standard clinical knee laxity tests and measured 3D knee kinematics during dynamic activities

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment 3D knee kinematic assessment under local anesthesia?

The research on knee kinematics shows that using advanced imaging techniques like 3D analysis can provide detailed information about knee movement, which is useful for understanding knee stability and function, especially in surgical settings. This suggests that 3D knee kinematic assessment could be effective in accurately evaluating knee movement and improving treatment outcomes. ^{1 2 3 4 5}

Is 3D knee kinematics assessment safe for humans?

The research articles do not provide specific safety data for 3D knee kinematics assessment in humans, but they discuss techniques and accuracy of knee injections and measurements, which are generally considered safe when performed correctly. ^{1 6 7 8 9}

How does 3D knee kinematic assessment under local anesthesia differ from other treatments for understanding knee movement?

This treatment is unique because it uses advanced imaging techniques to capture dynamic, three-dimensional movements of the knee in real-time, providing a detailed understanding of knee joint mechanics during motion, which is not possible with traditional static imaging methods. ^{1 2 5 10 11}

Research Team

Frédéric Lavoie, MD MSc FRCSC

Principal Investigator

CHUM

Eligibility Criteria

This trial is for patients who are scheduled for knee arthroscopy due to a medial meniscal tear and can move their knee well enough to do certain tasks. People with active infections, severe knee swelling, stiff knees that can't bend fully, or those who limp heavily cannot participate.

Inclusion Criteria

I am waiting for a knee surgery under local anesthesia for a tear in my knee's inner cartilage.

Exclusion Criteria

I cannot fully straighten my knee.

I cannot perform the physical activities required by the study.

I have a noticeable limp.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

3D Kinematic Assessment

3D knee kinematic assessment under local anesthesia using a novel minimally invasive measuring system

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the kinematic assessment

4 weeks

Treatment Details

Interventions

• 3D knee kinematic assessment under local anesthesia

Trial Overview The study is testing a new system that uses personalized 3D bone imaging and a device attached to the bone through the skin under local anesthesia. It aims to precisely measure how the knee moves during physical activities and daily life.

Participant Groups

Group I: 3D knee kinematic assessment Experimental Treatment 1 Intervention

3D knee kinematic assessment under local anesthesia

Who Is Running the Clinical Trial?

Centre hospitalier de l'Université de Montréal (CHUM)

Lead Sponsor

Trials

389

Recruited

143,000+

Eiffel Medtech

Industry Sponsor

Trials

2

Recruited

40+

Findings from Research

In a study involving 10 patients with unilateral ACL insufficiency, the ACL-insufficient knees showed significantly greater anterior-posterior translation of the medial femoral epicondyle (11.5 mm) compared to the healthy contralateral knees (7.7 mm), indicating altered knee mechanics during the Lachman test.

The study also found that during the Lachman test, the distal femur rotated externally more than the proximal tibia, highlighting differences in knee joint motion between ACL-insufficient and healthy knees.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Dynamic Three-Dimensional Analysis of Lachman Test for Anterior Cruciate Ligament Insufficiency: Analysis of Anteroposterior Motion of the Medial and Lateral Femoral Epicondyles. Koo, S., Kyung, BS., Jeong, JS., et al.[2020]

References

1. England pubmed.ncbi.nlm.nih.gov

Effect of skin movement artifact on knee kinematics during gait and cutting motions measured in vivo. [2022]

2. England pubmed.ncbi.nlm.nih.gov

Dynamic Three-Dimensional Analysis of Lachman Test for Anterior Cruciate Ligament Insufficiency: Analysis of Anteroposterior Motion of the Medial and Lateral Femoral Epicondyles. [2020]

3. United States pubmed.ncbi.nlm.nih.gov

Joint Track Machine Learning: An Autonomous Method of Measuring Total Knee Arthroplasty Kinematics From Single-Plane X-Ray Images. [2023]

4. United States pubmed.ncbi.nlm.nih.gov

Knee stability before and after total and unicondylar knee replacement: in vivo kinematic evaluation utilizing navigation. [2013]

5. United States pubmed.ncbi.nlm.nih.gov

Passive kinematics and laxity of prosthetic knees and intact knees as measured by a novel computer-assisted system. [2013]

6. United States pubmed.ncbi.nlm.nih.gov

Sonographically Guided Anterior Cruciate Ligament Injection: Technique and Validation. [2019]

7. England pubmed.ncbi.nlm.nih.gov

Accuracy of Ultrasound-Guided versus Landmark-Guided Intra-articular Injection for Rat Knee Joints. [2020]

8. United States pubmed.ncbi.nlm.nih.gov

Where and how to inject the knee--a systematic review. [2022]

9. United States pubmed.ncbi.nlm.nih.gov

Measurement of joint kinematics using a conventional clinical single-perspective flat-panel radiography system. [2017]

10. United States pubmed.ncbi.nlm.nih.gov

A method for measurement of joint kinematics in vivo by registration of 3-D geometric models with cine phase contrast magnetic resonance imaging data. [2019]

11. England pubmed.ncbi.nlm.nih.gov

Accelerated 4D self-gated MRI of tibiofemoral kinematics. [2018]