Study Summary
This trial is studying a combination of drugs as a potential treatment for acute myeloid leukemia.
- Acute Myeloid Leukemia
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 4 Secondary · Reporting Duration: Up to 5 years
Trial Safety
Safety Progress
Side Effects for
Trial Design
1 Treatment Group
Treatment (cladribine, cytarabine, venetoclax, azacitidine)
1 of 1
Experimental Treatment
145 Total Participants · 1 Treatment Group
Primary Treatment: Venetoclax · No Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 8 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- Kadia TM, Reville PK, Wang X, Rausch CR, Borthakur G, Pemmaraju N, Daver NG, DiNardo CD, Sasaki K, Issa GC, Ohanian M, Montalban-Bravo G, Short NJ, Jain N, Ferrajoli A, Bhalla KN, Jabbour E, Takahashi K, Malla R, Quagliato K, Kanagal-Shamanna R, Popat UR, Andreeff M, Garcia-Manero G, Konopleva MY, Ravandi F, Kantarjian HM. Phase II Study of Venetoclax Added to Cladribine Plus Low-Dose Cytarabine Alternating With 5-Azacitidine in Older Patients With Newly Diagnosed Acute Myeloid Leukemia. J Clin Oncol. 2022 Nov 20;40(33):3848-3857. doi: 10.1200/JCO.21.02823. Epub 2022 Jun 15.
- 2018. "Venetoclax, Cladribine, Low Dose Cytarabine, and Azacitidine in Treating Patients With Previously Untreated Acute Myeloid Leukemia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03586609.
Frequently Asked Questions
What is the official stance of the FDA on Venetoclax?
"There is some clinical data supporting Venetoclax's safety, but none demonstrating its efficacy; it received a score of 2." - Anonymous Online Contributor
Are people with the relevant health condition able to participate in this trial right now?
"Yes, this study is still looking for individuals to participate. The listing on clinicaltrials.gov shows that the trial was first posted on October 25th 2018 and edited September 19th 2020." - Anonymous Online Contributor
Can you name a few other studies where Venetoclax has been used?
"Venetoclax is being investigated in 572 active clinical trials, the majority of which are in Phase 3. Although most of the research for Venetoclax is taking place in Edmonton, Alberta, there are 19891 total locations running clinical trials for this medication." - Anonymous Online Contributor
For what ailments is Venetoclax commonly prescribed?
"Venetoclax has many potential applications, including the treatment of small lymphocytic lymphoma, malignant neoplasms, hairy cell leukemia, and multiple sclerosis." - Anonymous Online Contributor
How many individuals are participating in this test?
"That is correct, the online clinicaltrials.gov registry currently lists this trial as recruiting patients. The listing includes the date when the study was first posted (10/25/2018) as well as the most recent edit (9/19/2022). This particular research project is only enrolling 85 participants at a single site." - Anonymous Online Contributor