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Radiation Therapy

SBRT for Kidney Cancer (AQuOS-RCC Trial)

N/A

Waitlist Available

Research Sponsored by Sunnybrook Health Sciences Centre

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Histologic diagnosis of RCC where possible, or radiologic evidence of growth on surveillance

Medically inoperable or patient who refuses surgery

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years after completion of treatment

Awards & highlights

AQuOS-RCC Trial Summary

This trial is investigating whether SBRT is an effective cancer treatment, and whether it improves quality of life.

Who is the study for?

This trial is for adults who can't have surgery or choose not to, with kidney tumors larger than 2.5cm or recurring after treatment. They should be diagnosed with renal cell carcinoma (RCC) if possible, or show tumor growth on scans.Check my eligibility

What is being tested?

The study tests Stereotactic body radiotherapy (SBRT), a high-precision radiation therapy aimed at treating non-surgical patients with RCC to see how it affects their quality of life and cancer control.See study design

What are the potential side effects?

While the side effects specific to SBRT in this trial are not listed, generally SBRT may cause fatigue, skin reactions, nausea, and potential damage to nearby organs depending on the site treated.

AQuOS-RCC Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My kidney cancer diagnosis was confirmed by a biopsy or by growth seen on scans.

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I cannot undergo surgery for medical reasons or I choose not to have surgery.

Select...

My cancer lesion is larger than 2.5cm or has come back after treatment.

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I am 18 years old or older.

AQuOS-RCC Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years after completion of treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years after completion of treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years after completion of treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Patient Quality of Life

Secondary outcome measures

Cost-Effectiveness

Oncologic Outcomes

Treatment-Related Toxicity

Side effects data

From 2024 Phase 2 trial • 57 Patients • NCT03004183

21%

Fatigue

13%

Nausea

11%

Back pain

Shortness of Breath

Anemia

Abdominal pain

Diarrhea

Pneumonia

Kidney Injury and/or Infection

Dyspnea

Weight Loss

Malnutrition, Hypercalcemia and Weakness

Pneumothorax

Intractable pain, back pain, hip pain

Activated partial thromboplastin time prolonged

Pleural effusion

Atrial fibrillation with rapid ventricular response

Thrombocytopenia

Respiratory failure

Skin rash

colitis

100%

80%

60%

40%

20%

Study treatment Arm

Single Arm

AQuOS-RCC Trial Design

1Treatment groups

Experimental Treatment

Group I: SBRTExperimental Treatment1 Intervention

RCC patients

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

SBRT

2014

Completed Phase 2

~1060

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor

656 Previous Clinical Trials

1,551,407 Total Patients Enrolled

Juravinski Cancer CenterOTHER

12 Previous Clinical Trials

2,279 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available vacancies for individuals to participate in this experiment?

"Evidently, this clinical trial is not presently accepting new participants. The medical study was initially posted on June 1st 2015 and the most recent update occurred on December 15th 2020. Despite no longer being open for enrolment, there are still 2668 other trials actively recruiting patients."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Assessment of QoL and Outcomes With SBRT for RCC

William Chu, MD, MSc, FRCPC 2015. "Assessment of QoL and Outcomes With SBRT for RCC". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03108703.

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