This trial will test the effectiveness of durvalumab, a new immunotherapy drug, in combination with other cancer treatments, for people with first-line metastatic triple negative breast cancer.
- Triple Negative Breast Cancer
2 Primary · 7 Secondary · Reporting Duration: On-study tumor assessments occur every 8 weeks until week 48 (Arms 1-5), every 6 weeks until week 48 (Arms 6-7) and then every 12 weeks thereafter until radiological progression, death, withdrawal of consent or study completion up to approx. 30 months
Side Effects for
5 Treatment Groups
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210 Total Participants · 5 Treatment Groups
Primary Treatment: Durvalumab · No Placebo Group · Phase 1 & 2
Who is running the clinical trial?
Age 18 - 130 · Female Participants · 7 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
Frequently Asked Questions
What is the goal of this research?
"The primary outcome for this trial, as measured by the study sponsor AstraZeneca, will be incidence of adverse events. This data point will be collected over a 3 or 6-month period depending on which part of the study the patient is in. Additionally, secondary outcomes being assessed include objective response rate and duration of response." - Anonymous Online Contributor
What are some of the most common conditions that Durvalumab is used to manage?
"While often used to treat metastatic bladder cancer, durvalumab has also been proven effective against other illnesses such as advanced thymoma, AIDS, and malignant neoplasms." - Anonymous Online Contributor
Are people currently signing up to participate in this experiment?
"Unfortunately, this study is not currently enrolling patients. It was originally posted on December 21st, 2018 and has since been edited September 20th, 2022. However, there are plenty of other trials you may be eligible for; There are 4749 studies actively recruiting participants with triple negative breast neoplasms and 1211 for Durvalumab." - Anonymous Online Contributor
Are elderly people eligible for this experiment?
"This clinical trial only enrolls patients that are between 18-130 years old. There are 407 other studies for minors and 5,672 different trials for senior citizens." - Anonymous Online Contributor
Are there a lot of hospitals conducting this research in Canada?
"At the moment, this experiment is taking place at 10 different hospitals. The locations are Saint Louis, London and Greenfield Park amongst other places. If you want to make the process more convenient, choose a clinic that is close to your home." - Anonymous Online Contributor
Might I be eligible to take part in this clinical trial?
"Patients that have been diagnosed with triple negative breast neoplasms and are between 18-130 years old may qualify for this clinical trial. A total of 210 patients will be enrolled in the study." - Anonymous Online Contributor
Can you provide a list of other scientific investigations that have employed Durvalumab?
"City of Hope Comprehensive Cancer Center hosted the first study on durvalumab in 1997. Since then, there have been 1257 completed clinical trials and 1211 active ones. Many of these studies take place in Saint Louis, Missouri." - Anonymous Online Contributor