Clinical TrialsMetastatic Breast Cancer Clinical Trials 2022
Reviewed by Michael Gill, B. Sc.
Image of Dana Farber Cancer Institute in Boston, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

10e7 PFU Dose 3 Injectionsfor Neoplasm Metastasis

18+
All Sexes
The goal of this phase 1 open label clinical trial is to evaluate the safety and preliminary efficacy of CodaLytic, an intratumorally-administered oncolytic virus, in patients with metastatic or otherwise inoperable breast cancer. The main questions it aims to answer are: How safe is CodaLytic when administered in escalating dosing groups into targeted lesions? What is the impact of CodaLytic on lesion response and disease progression? Eligible participants will be enrolled into four (4) escalating dose groups and treated with Codalytic through injection into a selected lesion(s) over twelve (12) weeks and then followed for up to one (1) year after the first dose. A safety committee will review the safety profile of each dosing group before the next dose-escalation. Study procedures will include physical examinations, injection site assessments, biopsies, imaging, and collection of blood/urine to assess safety, the body's immune response, and efficacy.
Phase 1
Waitlist Available
Dana Farber Cancer Institute (+1 Sites)Codagenix, Inc
Image of Harborview Medical Center in Seattle, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Survey-based Patient/Clinician Jumpstartfor Pneumonia, Interstitial

18+
All Sexes
This trial is testing whether or not the Jumpstart intervention can improve patient-centered outcomes for those with chronic illness. The study will specifically look at Alzheimer's disease and related dementias, but will also include other common chronic illnesses. The trial will assess the efficacy of the intervention by measuring quality of care, intensity of care outcomes, and patient- and family-reported outcomes. There will also be a mixed-methods evaluation of the implementation of the intervention to explore barriers and facilitators to future implementation and dissemination.
Recruiting
Has No Placebo
Harborview Medical Center (+2 Sites)J. Randall Curtis, MD, MPH
25 Metastatic Breast Cancer Clinical Trials Near Me
Top Hospitals for Metastatic Breast Cancer Clinical Trials
Image of Washington University School of Medicine in Missouri.
Washington University School of Medicine
Saint Louis
16Active Trials
12All Time Trials for Metastatic Breast Cancer
2008First Metastatic Breast Cancer Trial
Top Cities for Metastatic Breast Cancer Clinical Trials
Image of Boston in Massachusetts.
Boston
71Active Trials
Dana Farber Cancer InstituteTop Active Site
Image of New York in New York.
New York
67Active Trials
Memorial Sloan Kettering Cancer CenterTop Active Site
Metastatic Breast Cancer Clinical Trials by Phase of Trial
Phase < 1 Metastatic Breast Cancer Clinical Trials
3Active Metastatic Breast Cancer Clinical Trials
3Number of Unique Treatments
3Number of Active Locations
TamoxifenArm BMultiparametric Magnetic Resonance Imaging