Dystonia Clinical Trials 2022

Browse 24 Dystonia Medical Studies Across 38 Cities

1 Phase 3 Trial · 74 Dystonia Clinics

Reviewed by Michael Gill, B. Sc.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

2for Dystonia

Toronto, Canada
18+
All Sexes
Patients with focal dystonia experience uncontrollable movements of the hand during certain types of skilled movements. Though the origin of the disorder is not fully understood, it is thought that brain areas involved in moving the hands and receiving touch information from the hands, are involved. For example, patients with dystonia affecting the hand show changes in their ability to perceive touch - this is something that typically escapes the patients own awareness. Further, the area of the brain receiving touch information has a disrupted representation of the finger skin surfaces. The goal of our research is to improve dystonia symptoms in patients with hand dystonia. We will attempt to achieve this goal by implementing an intensive training treatment that requires patients to attend to, and use touch information applied to specific fingertips. Previous work has attempted to alter touch perception using sensory training and improvements in motor control (hand writing) of dystonia patients were observed. For example, learning to read Braille improves tactile perception and handwriting in focal hand dystonia. A different approach to treat focal hand dystonia involves a technique called repetitive transcranial magnetic stimulation (rTMS), and this can also temporarily improve hand writing in dystonia patients. The proposed research will attempt to alter touch processing using touch training alone, or in combination with rTMS. Rather than train using Braille reading, the sensory training will be applied using a systematic, experimenter controlled stimulus set that focuses on touch stimuli applied to individual digits. Importantly patients will have to associate certain types of touch information with rewards and other touch input with the lack of a reward. The study will first involve measuring the location and representation of the touch in the brain using multiple brain mapping tools. These tools include functional magnetic resonance imaging and magnetoencephalography; when both tools are used a very accurate picture of finger representation can be obtained, and we also know what brain areas respond to touch stimuli. Dystonia symptoms and touch perception will also be assessed. Next, patients will participate in a training intervention that involves 15 days(2.5 hr/day) of touch training applied to the fingertips of the dystonia affected hand. Patients will identify the touch targets amongst distractors and receive on-line performance feedback. The goal of the training is to provide the cortex with regular boundaries of fingers and in this way, attempt to re-shape the sensory cortex to accept these boundaries. Another group of patients will receive rTMS. The goal of the rTMS is to create an environment in sensory cortex that is open or 'ready' to accept changes induced by tactile stimulation. The rTMS will be immediately followed by the tactile training. A third group of patients will receive a placebo version of rTMS followed by tactile training. The latter group will allow us to understand if rTMS has a definite effect on the physiology of the patient. Following the 15-day training, we will assess the brains representation of fingertips, changes in dystonia symptoms and changes in the perception of touch stimuli. This research will advance the treatment of focal hand dystonia and assist the design of precise remediation training tailored to the dystonia patient.
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Senior-friendly
24 Dystonia Clinical Trials Near Me
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Boston, MA
San Francisco, CA
Boston, MA
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Most Popular References for Dystonia Clinical Trials
Frequency
Citation
Top Hospitals for Dystonia Clinical Trials
Location
Active Dystonia Clinical Trials
All Time Trials for Dystonia
First Recorded Dystonia Trial
Trials
Massachusetts General Hospital, Boston, Massachusetts
2
2
2020
NeuroStudies.net, Decatur, Georgia
2
2
2021
Central Texas Neurology Consultants PA, Round Rock, Texas
2
2
2021
Baylor College of Medicine, Houston, Texas
2
9
2005
Top Treatments for Dystonia Clinical Trials
Treatment Name
Active Dystonia Clinical Trials
All Time Trials for Dystonia
First Recorded Dystonia Trial
Trials
DystoniaNet-based diagnosis of isolated dystonia
1
1
2022
Brain imaging
1
1
2022
Deep Brain Stimulation
1
6
2011
repetitive transcranial magnetic stimulation (rTMS)
1
1
2021
Top Cities for Dystonia Clinical Trials
City
Active Dystonia Clinical Trials
Top Active Site for Dystonia Clinical Trials
Trial List
Cleveland, Ohio
4
The Cleveland Clinic Foundation
Scottsdale, Arizona
3
Movement Disorders Center of Arizona, LLC
Most Recent Dystonia Clinical Trials
Phase 3 Dystonia Clinical Trials
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Pediatric Dystonia Clinical Trials
Senior Friendly Dystonia Clinical Trials

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 11th, 2021

Last Reviewed: August 6th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.