← Back to Search

Procedure

Accelerated TMS for Hand Dystonia

N/A

Recruiting

Led By Noreen Bukhari-Parlakturk, MD PhD

Research Sponsored by Duke University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

18yrs and older

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 0 days, 2 weeks and 12 weeks post-tms

Awards & highlights

Study Summary

This trial studies the effects of a type of brain stimulation on people with focal hand dystonia to improve behavior and understand brain changes from the treatment.

Who is the study for?

This trial is for adults over 18 with isolated focal hand dystonia, confirmed by a neurologist. Participants must be right-handed, able to give informed consent and literate. Excluded are those with other movement disorders or seizure history, recent drug use or certain treatments like TMS therapy, botulinum toxin injections, specific medications for dystonia symptoms, and recent hand therapy.Check my eligibility

What is being tested?

The study tests accelerated transcranial magnetic stimulation (TMS) on patients with focal hand dystonia. It involves four TMS sessions in one day and assesses the impact on brain function and writing behavior immediately after, at two weeks and twelve weeks post-treatment using functional MRI scans.See study design

What are the potential side effects?

While TMS is generally safe when following guidelines, the main potential side effect of concern is seizures; however, risks are minimized through careful participant screening and adherence to safety protocols.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 0 days, 2 weeks and 12 weeks post-tms

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~0 days, 2 weeks and 12 weeks post-tms

This trial's timeline: 3 weeks for screening, Varies for treatment, and 0 days, 2 weeks and 12 weeks post-tms for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in behavioral writing measure

Change in brain connectivity in the motor network

Trial Design

3Treatment groups

Active Control

Placebo Group

Group I: TMS to premotor cortexActive Control1 Intervention

Participants receive TMS at premotor cortex

Group II: TMS to primary somatosensory cortexActive Control1 Intervention

Participants received TMS sessions at primary somatosensory cortex

Group III: TMS at low amplitude to primary somatosensory cortexPlacebo Group1 Intervention

Participants receive TMS at a cortical target at smaller amplitude

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Duke UniversityLead Sponsor

2,364 Previous Clinical Trials

3,420,622 Total Patients Enrolled

American Academy of NeurologyOTHER

11 Previous Clinical Trials

352 Total Patients Enrolled

Noreen Bukhari-Parlakturk, MD PhDPrincipal InvestigatorDuke Health

1 Previous Clinical Trials

50 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there availability for participants in this clinical trial?

"As per the data on clinicaltrials.gov, this particular trial is not actively recruiting participants at present. Originally posted to the site in September 1st 2023 and updated for the last time on August 23rd 2023, it has reached its patient quota but there are currently 29 other trials that require volunteers."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Accelerated TMS for Focal Hand Dystonia

2023. "Accelerated TMS for Focal Hand Dystonia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06015672.

All > Dystonia