Supervised Exercise for Transplant Recipients
Trial Summary
What is the purpose of this trial?
This is an interventional pilot study to determine whether implementation of a supervised exercise program can improve outcomes in subjects undergoing allogeneic HCT. The primary objective is to determine feasibility. Up to 60-72 evaluable subjects will be enrolled. Evaluable subjects are defined as those participating in the exercise intervention.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It focuses on a supervised exercise program for transplant recipients.
What data supports the effectiveness of this treatment for transplant recipients?
Is supervised exercise generally safe for transplant recipients?
Supervised exercise programs, like cardiac rehabilitation, are generally safe for patients, including those who have had heart transplants, as long as they are selected based on their physical and psychological conditions. However, patients at high risk, such as those with certain heart conditions, should be cautious and may need more careful monitoring during exercise.678910
How is the supervised exercise program treatment for transplant recipients different from other treatments?
The supervised exercise program for transplant recipients is unique because it focuses on structured physical activity to improve exercise capacity, muscle strength, and quality of life, which are not typically addressed by standard medical treatments. This program is tailored to the specific needs of transplant patients, offering both prehabilitation (before surgery) and rehabilitation (after surgery) to enhance recovery and reduce cardiovascular risks.1691112
Research Team
Shannon McCurdy, MD
Principal Investigator
Penn Medicine
Eligibility Criteria
This trial is for older adults (60+) who are either pre-frail or frail and are planning to undergo or have undergone an allogeneic hematopoietic cell transplant (HCT) due to a blood cancer. Participants will be split into two groups: one that starts the exercise program before HCT and another that begins after HCT.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Prehabilitation
Pre-frail and frail subjects attend at least twice weekly exercise sessions with a physical therapist and complete an exercise program at home prior to admission for HCT
Rehabilitation
All patients 60 years and older attend at least weekly exercise sessions with a physical therapist and complete an exercise program at home through Day +100 after HCT
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Exercise Program (Cohort A Prehab)
- Exercise Program (Cohort B Rehab)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Abramson Cancer Center of the University of Pennsylvania
Lead Sponsor
Abramson Cancer Center at Penn Medicine
Lead Sponsor