Reduced Nicotine Cigars for Smoking Addiction
(LOWFLC Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, you must abstain from all tobacco and nicotine for at least 12 hours before lab sessions.
What data supports the effectiveness of the treatment Reduced Nicotine Content Cigars for smoking addiction?
Research on reduced nicotine content cigarettes shows that lowering nicotine levels can decrease the demand for smoking and reduce the addiction potential without increasing smoking intensity. This suggests that similar reduced nicotine content cigars might help people smoke less and reduce their addiction.12345
Is it safe to use reduced nicotine cigars for smoking addiction?
There is no specific safety data available for reduced nicotine cigars, but some studies suggest that reduced nicotine products may deliver less harmful substances compared to regular tobacco products. However, it's important to note that little cigars and cigarillos are likely as dangerous as cigarettes, and more research is needed to fully understand their safety.16789
How do reduced nicotine content cigars differ from other smoking addiction treatments?
Reduced nicotine content cigars are unique because they aim to lower nicotine intake while still providing the sensory experience of smoking, which can help reduce cravings and support smoking cessation. Unlike traditional methods that focus solely on nicotine replacement or cessation aids, this approach addresses both the physical and psychological aspects of smoking addiction.13101112
What is the purpose of this trial?
The goal of this clinical trial is to learn how reducing the nicotine content in filtered little cigars can affect the the use of these cigars and lung health in current adult filtered little cigar users. The main question\[s\] it aims to answer are:Are puffing behaviors, appeal/satisfaction, craving suppression, pharmacokinetic effects, and demand similar between the regular cigars smoked by participants, normal nicotine study cigars and very low nicotine study cigars? Are health effects and toxicant exposure similar between the regular cigars smoked by participants, normal nicotine study cigars and very low nicotine study cigars?Participants will attend three study visits at OSU. Each visit would last up to 4 hours. During visits, they will* fill several surveys* provide blood samples* perform breathing tests* complete smoking sessions using either their own cigars or the study cigars.
Research Team
Dharini M Bhammar, PhD
Principal Investigator
Ohio State University
Eligibility Criteria
This trial is for adult smokers who regularly use filtered little cigars. Participants must be willing to attend three study visits at OSU, which include surveys, blood samples, breathing tests, and smoking sessions with different types of cigars.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants attend three study visits at OSU, each lasting up to 4 hours, to complete surveys, provide blood samples, perform breathing tests, and participate in smoking sessions using either their own cigars or the study cigars.
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Reduced Nicotine Content Cigars
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University Comprehensive Cancer Center
Lead Sponsor