Stress Induction for Borderline Personality Disorder
Trial Summary
Will I have to stop taking my current medications?
The trial requires participants to refrain from using certain medications, specifically as needed antihypertensive agents and psychotropic medications, for 12 hours before the lab visit.
How does the stress induction treatment differ from other treatments for borderline personality disorder?
Stress induction treatment for borderline personality disorder is unique because it focuses on the role of stress in both causing and being caused by symptoms, unlike other treatments that may not specifically target stress. This approach considers the altered stress response in BPD, particularly involving the hypothalamus-pituitary-adrenal (HPA) axis, which is often dysfunctional in these patients.12345
What is the purpose of this trial?
The purpose of this research study is to investigate how personality traits and neuroendocrine systems relate to decision-making patterns in individuals 18-45 years old. The main question it aims to answer is how neuroendocrine activity impacts decision-making.Participants will complete online behavioral tasks, a stress induction procedure, self-report surveys, and a cognitive assessment. During the session, psychophysiological measures will be collected, including electrocardiogram (ECG) and cardiac impedance (ICG) to monitor heart rate and blood flow, as well as electrodermal activity (EDA), blood drop samples, and saliva collection to assess nervous system activity.
Research Team
Michael Hallquist, PhD
Principal Investigator
University of North Carolina, Chapel Hill
Eligibility Criteria
This trial is for individuals aged 18-45 who may have personality traits associated with impulsivity or are diagnosed with Borderline Personality Disorder (BPD). Healthy participants without these conditions can also join as controls. Specific eligibility criteria details were not provided.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Session 1
Participants complete online behavioral tasks, a stress induction procedure, self-report surveys, and a cognitive assessment. Psychophysiological measures are collected.
Follow-up
Participants are monitored for any immediate effects post-session and data is analyzed for decision-making patterns.
Treatment Details
Interventions
- Stress Induction
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of North Carolina, Chapel Hill
Lead Sponsor
North Carolina Translational and Clinical Sciences Institute
Collaborator